ChemicalBook > CAS DataBase List > 6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid

6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid

Product Name
6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid
CAS No.
2172819-74-6
Chemical Name
6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid
Synonyms
VH032-C3-COOH;VH 032-linker 5;(S,R,S)-AHPC-C4-COOH;VH 032 amide-alkylC4-acid;(S,R. S)-AHPC-pentanoic-acid;L-Prolinamide, N-(5-carboxy-1-oxopentyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;6-[[(S)-1-[(2S,4R)-4-Hydroxy-2-[[4-(4-methyl-5-thiazolyl)benzyl]carbamoyl]-1-pyrrolidinyl]-3,3-dimethyl-1-oxo-2-butyl]amino]-6-oxohexanoic Acid;6-(((R)-1-((2R,4S)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid;6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid;5-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}pentanoic acid
CBNumber
CB84902854
Molecular Formula
C28H38N4O6S
Formula Weight
558.69
MOL File
2172819-74-6.mol
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6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid Property

Boiling point:
878.5±65.0 °C(Predicted)
Density 
1.272±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO, DMF
pka
4.70±0.10(Predicted)
form 
Solid
color 
white to light yellow
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Safety

HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
6680
Product name
VH032amide-alkylC4-acid
Purity
≥95%(HPLC)
Packaging
25
Price
$212
Updated
2021/12/16
BroadPharm
Product number
BP-24508
Product name
(S,R.S)-AHPC-pentanoic-acid
Purity
98%
Packaging
100mg
Price
$540
Updated
2021/12/16
BroadPharm
Product number
BP-24508
Product name
(S,R.S)-AHPC-pentanoic-acid
Purity
98%
Packaging
250mg
Price
$980
Updated
2021/12/16
BroadPharm
Product number
BP-24508
Product name
(S,R.S)-AHPC-pentanoic-acid
Purity
98%
Packaging
500mg
Price
$1800
Updated
2021/12/16
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6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid Chemical Properties,Usage,Production

Description

(S, R, S)-AHPC-pentanoic-acid is a PROTAC linker that incorporate an E3 ligase ligand with a linker to empower PROTAC drug research & discovery. It can react with amine containing molecules.

storage

Store at -20°C

6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid Suppliers

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2172819-74-6, 6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acidRelated Search:


  • 6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid
  • VH 032-linker 5
  • (S,R. S)-AHPC-pentanoic-acid
  • VH 032 amide-alkylC4-acid
  • L-Prolinamide, N-(5-carboxy-1-oxopentyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
  • 6-[[(S)-1-[(2S,4R)-4-Hydroxy-2-[[4-(4-methyl-5-thiazolyl)benzyl]carbamoyl]-1-pyrrolidinyl]-3,3-dimethyl-1-oxo-2-butyl]amino]-6-oxohexanoic Acid
  • (S,R,S)-AHPC-C4-COOH
  • VH032-C3-COOH
  • 6-(((R)-1-((2R,4S)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid
  • 5-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}pentanoic acid
  • 2172819-74-6