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D-THREO-METHYLPHENIDATE HYDROCHLORIDE

Product Name
D-THREO-METHYLPHENIDATE HYDROCHLORIDE
CAS No.
19262-68-1
Chemical Name
D-THREO-METHYLPHENIDATE HYDROCHLORIDE
Synonyms
D03721;Focalin;Focalin (tn);D-METHYLPHENIDATE;Dexmethylphenidate HCl;d-threo-Methylphenidate;d-threo-Form hydrochloride;DEXMETHYLPHENIDATE HYDROCHLORIDE;Methylphenidate-d6 hydrochloride;DexaMethylphenedate Hydrochloride
CBNumber
CB8490337
Molecular Formula
C14H20ClNO2
Formula Weight
269.77
MOL File
19262-68-1.mol
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D-THREO-METHYLPHENIDATE HYDROCHLORIDE Property

Melting point:
218-220°C
storage temp. 
Controlled Substance, -20°C Freezer
solubility 
Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Off-White
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Safety

Hazard Codes 
Xn
Risk Statements 
22
RTECS 
TM3850000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D-170
Product name
Dexmethylphenidate hydrochloride solution
Purity
1?mg/mL in methanol (as free base), certified reference material, ampule of 1?mL
Packaging
1ML
Price
$206
Updated
2022/05/15
Chemtos
Product number
M-2720
Product name
D-threomethylphenidateHydrochloride
Packaging
25mg
Price
$1090
Updated
2021/12/16
Chemtos
Product number
M-2720
Product name
D-threomethylphenidateHydrochloride
Packaging
50mg
Price
$1090
Updated
2021/12/16
Chemtos
Product number
M-2719
Product name
D-threomethylphenidatelabeledd6Hydrochloride
Packaging
25mg
Price
$1490
Updated
2021/12/16
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D-THREO-METHYLPHENIDATE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Dexmethylphenidate, the pharmacologically effective enantiomer of d,l-methyl phenidate (Ritalin?) was developed as an improved treatment for attention deficit hyperactivity disorder (ADHD) in children. Dexmethylphenidate acts via the inhibition of reuptake of dopamine (by binding to dopamine transporter) and nor-adrenaline. It is thought to block dopamine and noradrenaline reuptake into the presynaptic neuron and increase neurotmnsmitter release into the extraneuronal space. Dexmethytphenidate, at half the usual dose of racemic methylphenidate, improved the symptoms of attention deficit hyperactivity disorder to a similar extent to methylphenidate in both home and school settings (SNAP-ADHD scores) at 3 h post dosing. Moreover, some studies showed that dexmethylphenidate has a statistically significant longer duration of action than the racemic form as measured by a behavioral scale at 6 h post dosing compared to placebo. In patients with ADHD, plasma dexmethylphenidate concentrations increased rapidly, reaching a maximum in the fasted state at approximately l-l.5 h post-dose. The mean plasma half-life for dexmethylphenidate is approximately 2.2 h. Dexmethylphenidate is metabolized to d-α-phenyl-piperidine acetic acid, its main urinary metabolite which has negligible pharmacological activity. In vitro studies showed that dexmethylphenidate did not inhibit cytochrome P450 isozymes. Dexmethylphenidate was well tolerated; the most commonly reported adverse events (abdominal pain, headache, anorexia, insomnia) were mild in severity and consistent with those known to be associated with agents containing methylphenidate. Current labeling states that dexmethylphenidate should be administered twice daily with an interval of at least 4 hours between doses. Stimulant medications have been used for over sixty years and remain, until now, the first line pharmacological therapy for children with ADHD, demonstrating effectiveness in roughly 70% of patients.

Chemical Properties

White Solid

Originator

Celgene (USA)

Uses

Controlled substance. CNS stimulant. More potent enantiomer

Uses

Controlled substance. CNS stimulant. The more potent isomers of Methylphenidate. The threo enantomers have shown that the pharmacological activity residues predominantly in the d-threo enantiomer.

brand name

Focalin (Novartis).

D-THREO-METHYLPHENIDATE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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D-THREO-METHYLPHENIDATE HYDROCHLORIDE Suppliers

19262-68-1, D-THREO-METHYLPHENIDATE HYDROCHLORIDERelated Search:


  • Dexmethylphenidate HCl
  • (2R)-2-Phenyl-2-[(R)-2-piperidinyl]acetic acid methyl ester
  • (R)-[(2R)-Hexahydropyridine-2-yl]phenylacetic acid methyl ester
  • (R)-2-Phenyl-2-[(R)-2-piperidinyl]acetic acid methyl ester
  • [(αR,2R)-α-Phenyl-2β-piperidineacetic acid]methyl ester
  • d-threo-Methylphenidate
  • D03721
  • Dexmethylphenidate hydrochloride (usan)
  • Focalin
  • Focalin (tn)
  • D-erythro-Methylphenidate Hydrochloride
  • DexaMethylphenedate Hydrochloride
  • d-threo-Form hydrochloride
  • (R)-methyl 2-phenyl-2-((R)-piperidin-2-yl)acetate hydrochloride
  • DEXMETHYLPHENIDATE HYDROCHLORIDE
  • D-THREO-METHYLPHENIDATE HYDROCHLORIDE
  • D-METHYLPHENIDATE
  • (2R,2’R)-(+)-threo-Methyl a-Phenyl-a-(2-piperidyl)acetate Hydrochloride
  • D-threo-Methylphenidate Hydrochloride (1.0mg/ml in Methanol)
  • Dexmethylphenidate HydrochlorideQ: What is Dexmethylphenidate Hydrochloride Q: What is the CAS Number of Dexmethylphenidate Hydrochloride Q: What is the storage condition of Dexmethylphenidate Hydrochloride
  • methyl (R)-2-phenyl-2-((R)-piperidin-2-yl)acetate
  • Methylphenidate-d6 hydrochloride
  • 19262-68-1
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  • Chiral Reagents
  • Intermediates & Fine Chemicals
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