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FB23-2

Product Name
FB23-2
CAS No.
2243736-45-8
Chemical Name
FB23-2
Synonyms
FB23-2;FB23-2，1.5g;FB23-2 ，S8837;FB23-2, 10 mM in DMSO;FB23-2(FTO Demethylase inhibitor FB23-2);2-[[2,6-Dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-N-hydroxybenzamide;2-((2,6-Dichloro-4-(3,5-dimethylisoxazol-4-yl)phenyl)amino)-N-hydroxybenzamide;Benzamide, 2-[[2,6-dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-N-hydroxy-;FB23 2,AML,Apoptosis,leukemia,acute,anti-proliferation,Inhibitor,FB232,m6A,myeloid,mRNA,inhibit,FB23-2,demethylase,FB-23-2
CBNumber
CB84908508
Molecular Formula
C18H15Cl2N3O3
Formula Weight
392.24
MOL File
2243736-45-8.mol
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FB23-2 Property

Density 
1.428±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO:70.25(Max Conc. mg/mL);179.1(Max Conc. mM)
form 
A solid
pka
8.72±0.40(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P233Keep container tightly closed.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304IF INHALED:

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P362Take off contaminated clothing and wash before reuse.

P403Store in a well-ventilated place.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb611563
Product name
FB23-2 (FTO Demethylase inhibitor FB23-2)
Packaging
100mg
Price
$1654.1
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611563
Product name
FB23-2 (FTO Demethylase inhibitor FB23-2)
Packaging
250mg
Price
$3282.7
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611563
Product name
FB23-2 (FTO Demethylase inhibitor FB23-2)
Packaging
1g
Price
$6545
Updated
2021/12/16
DC Chemicals
Product number
DC23119
Product name
FB23-2(FTODemethylaseinhibitorFB23-2)
Purity
>98%
Packaging
100mg
Price
$800
Updated
2021/12/16
DC Chemicals
Product number
DC23119
Product name
FB23-2(FTODemethylaseinhibitorFB23-2)
Purity
>98%
Packaging
1g
Price
$2800
Updated
2021/12/16
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FB23-2 Chemical Properties,Usage,Production

Uses

FB23-2 is a potent and selective inhibitor of mRNA N6-methyladenosine (m6A) demethylase FTO, with an IC50 of 2.6 μM. FB23-2 has anti-proliferation activity. FB23-2 can be used for the research of acute myeloid leukemia (AML)[1].

in vivo

FB23-2 (2 mg/kg; i.p.; daily; for 10 days) substantially suppresses leukemia progression and prolongs survival[1].
FB23-2 exhibits elimination half-life (rat 6.7 h) and Cmax (rat 2421.3 ng/mL) following intraperitoneal injection (rat 3 mg/kg)[1].

Animal Model:NOD/LtSz-scid IL2RG-SGM3 (NSGS) mice, xeno-transplanted with MONOMAC6 AML cells[1]
Dosage:2 mg/kg
Administration:Intraperitoneal injection, daily, for 10 days
Result:Delayed the onset of full-blown leukemic symptoms and significantly prolonged survival by almost doubling the median survival.
Animal Model:Sprague Dawley (SD) rats[1]
Dosage:3 mg/kg (Pharmacokinetic Analysis)
Administration:Intraperitoneal injection
Result:T1/2 (6.7 hours), Cmax (2421.3 ng/mL).

References

[1] Huang Y, et al. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell. 2019 Apr 15;35(4):677-691.e10. DOI:10.1016/j.ccell.2019.03.006

FB23-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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FB23-2 Suppliers

CHINA 75 United States 5 Global 80
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

2243736-45-8, FB23-2Related Search:


  • FB23-2
  • FB23-2(FTO Demethylase inhibitor FB23-2)
  • Benzamide, 2-[[2,6-dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-N-hydroxy-
  • FB23-2，1.5g
  • 2-[[2,6-Dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-N-hydroxybenzamide
  • FB23 2,AML,Apoptosis,leukemia,acute,anti-proliferation,Inhibitor,FB232,m6A,myeloid,mRNA,inhibit,FB23-2,demethylase,FB-23-2
  • 2-((2,6-Dichloro-4-(3,5-dimethylisoxazol-4-yl)phenyl)amino)-N-hydroxybenzamide
  • FB23-2, 10 mM in DMSO
  • FB23-2 ，S8837
  • 2243736-45-8