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MRS 1523

Product Name
MRS 1523
CAS No.
212329-37-8
Chemical Name
MRS 1523
Synonyms
MRS 1523 >98% (HPLC);UUSHFEVEROROSP-UHFFFAOYSA-N;3-propyl-6-ethyl-5-[(ethylthio)carbonyl]-2 phenyl-4-propyl-3-pyridine carboxylate;3-Pyridinecarboxylic acid, 6-ethyl-5-[(ethylthio)carbonyl]-2-phenyl-4-propyl-, propyl ester
CBNumber
CB8497073
Molecular Formula
C23H29NO3S
Formula Weight
399.55
MOL File
212329-37-8.mol
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MRS 1523 Property

Boiling point:
551.3±50.0 °C(Predicted)
Density 
1.100±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >10 mg/mL
form 
oil
pka
1.44±0.28(Predicted)
color 
colorless to light brown
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M1809
Product name
MRS 1523
Purity
>98% (HPLC)
Packaging
5mg
Price
$309
Updated
2024/03/01
Sigma-Aldrich
Product number
M1809
Product name
MRS 1523
Purity
>98% (HPLC)
Packaging
25mg
Price
$1230
Updated
2024/03/01
Cayman Chemical
Product number
17128
Product name
MRS 1523
Purity
≥98%
Packaging
1mg
Price
$56
Updated
2024/03/01
Cayman Chemical
Product number
17128
Product name
MRS 1523
Purity
≥98%
Packaging
5mg
Price
$188
Updated
2024/03/01
Cayman Chemical
Product number
17128
Product name
MRS 1523
Purity
≥98%
Packaging
10mg
Price
$348
Updated
2024/03/01
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MRS 1523 Chemical Properties,Usage,Production

Description

MRS1523 is a selective adenosine A3 receptor antagonist (Kis = 18.9 and 113 nM for human and rat A3 receptors, respectively, versus Kis = 15.6 and 2.05 μM for rat A1 and A2A receptors, respectively). As activation of the A3 receptor is linked to several second messenger systems for signaling pathways involving inflammatory, asthmatic, and ischemic responses, this selective antagonist may be useful in characterizing the various functions of the receptor.

Uses

MRS 1523 is a selective A3 adenosine receptor (A3AR) antagonist in human and rat.

Biochem/physiol Actions

MRS 1523 is a selective?adenosine A3 receptor antagonist in the rat.

in vitro

mrs1523 reversed the increase in mrna expression in b16-f10 melanoma cells. also, mrs1523 antagonized the modulation in the expression level of the proteins, which indicated that adenosine a3r mediated the responses [1].

in vivo

c57bl/6j, male mice, inoculated b16-f10 melanoma cells, were administered mrs1523 at a dose of 100 μg/kg orally twice daily for 15 days. mrs1523 counteracted the activity of ib-meca which is an adenosine a3r agonist. in addition, it was demonstrated that the response was adenosine a3r mediated. the modulation of up-regulation of gsk-3β expression level was neutralized by mrs1523, further suggesting the specificity of the response [1].

References

[1]. madi, l., rosenberg-haggen, b., nyska, a., & korenstein, r. enhancing pigmentation via activation of a3 adenosine receptors in b16 melanoma cells and in human skin explants. experimental dermatology. 2012; 22(1): 74-77.

MRS 1523 Preparation Products And Raw materials

Raw materials

Preparation Products

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MRS 1523 Suppliers

China 18 India 1 South Korea 1 Switzerland 1 United States 6 Global 27
Chembest Research Laboratories Limited
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+86-21-20908456
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Beijing Yisiyan Technology Research Center
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bjkaida@163.com
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Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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Energy Chemical
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marketing@energy-chemical.com
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Changzhou Furuisi Biotechnology Co., Ltd
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Beijing Fuchen Technology Co., Ltd
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China
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 15801484223;
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psaitong@jm-bio.com
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China
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Changzhou Bojia Biomedical Technology Co., Ltd.
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2122619822
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czbjpharma@126.com
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China
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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Nantong QuanYi Biotechnology Co., Ltd
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sales@chemhifuture.com
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Shenzhen Xingyue Biotechnology Co., Ltd
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18124513697; 18124513697
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RD International Technology Co., Limited
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Merck KGaA
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(+86) 21 2033 8288
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Shanghai Hao Zhun Biological Technology Co., Ltd.
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Guangzhou WeiBo Chemical Co., Ltd.
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weibochem@163.com
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China
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6187
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212329-37-8, MRS 1523Related Search:


  • 3-propyl-6-ethyl-5-[(ethylthio)carbonyl]-2 phenyl-4-propyl-3-pyridine carboxylate
  • UUSHFEVEROROSP-UHFFFAOYSA-N
  • 3-Pyridinecarboxylic acid, 6-ethyl-5-[(ethylthio)carbonyl]-2-phenyl-4-propyl-, propyl ester
  • MRS 1523 >98% (HPLC)
  • 212329-37-8