(R)-BUTAPROST
- Product Name
- (R)-BUTAPROST
- CAS No.
- 69648-38-0
- Chemical Name
- (R)-BUTAPROST
- Synonyms
- BAY-q-4218;Butaprostum;(1R)-3α-Hydroxy-2β-[(1E,4R)-4-hydroxy-4-(1-propylcyclobutan-1-yl)-1-butenyl]-5-oxocyclopentaneheptanoic acid methyl ester;(1r,2r,3r)-3-hydroxy-2-[(1e,4r)-4-hydroxy-4-(1-propylcyclobutyl)-1-butenyl]-5-oxo-cyclopentaneheptanoic acid methyl ester;Cyclopentaneheptanoic acid, 3-hydroxy-2-[(1E,4R)-4-hydroxy-4-(1-propylcyclobutyl)-1-buten-1-yl]-5-oxo-, methyl ester, (1R,2R,3R)-
- CBNumber
- CB8497927
- Molecular Formula
- C24H40O5
- Formula Weight
- 408.57
- MOL File
- 69648-38-0.mol
(R)-BUTAPROST Property
- storage temp.
- -20°C
- solubility
- DMSO: freely soluble
- form
- oil
- color
- light yellow
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
H336May cause drowsiness or dizziness
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B6309
- Product name
- (R)-Butaprost
- Purity
- ≥98% (HPLC)
- Packaging
- 1mg
- Price
- $220
- Updated
- 2024/03/01
- Product number
- B6309
- Product name
- (R)-Butaprost
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $687
- Updated
- 2024/03/01
- Product number
- 13745
- Product name
- (R)-Butaprost
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $135
- Updated
- 2024/03/01
- Product number
- 13745
- Product name
- (R)-Butaprost
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $601
- Updated
- 2024/03/01
- Product number
- 13745
- Product name
- (R)-Butaprost
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $1068
- Updated
- 2024/03/01
(R)-BUTAPROST Chemical Properties,Usage,Production
Description
Butaprost is a structural analog of prostaglandin E2 (PGE2) with good selectivity for the EP2 receptor subtype. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells. Serious confusion as to the structure of butaprost was generated by Gardiner in 1986, when he reported that the epimer of butaprost showing this selective activity was the C-
Uses
(R)-Butaprost has been used as a prostanoid receptor (EP)-specific agonist to study its effects on protein kinase A (PKA) regulatory subunits in MCF7 cells. It may be used as EP2 agonist in Madin-Darby canine kidney and mouse cortical collecting duct (mpkCCD14) cells. It may also be used as EP2 agonist in human fetal lung fibroblasts (HFL-1) cells to test its effect on vascular endothelial growth factor (VEGF) production.
Uses
Bronchodilator.
Biochem/physiol Actions
Butaprost comprises hydroxy-cyclopentanone ring and ω-chain. It aids protection in events of glutamate based N-methyl-D-aspartate receptor toxicity. Butaprost inhibits conjunctival fibrosis and lowers the intraocular pressure in post glaucoma filtration surgery. It also promotes wound healing by reducing the subconjunctival scarring Tenon′s fibroblasts. Butaprost plays a protective role in pulmonary fibrosis and aids protection against the aggregated amyloid β (Aβ) peptides in Alzheimer′s disease.
(R)-BUTAPROST Preparation Products And Raw materials
Raw materials
Preparation Products
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