DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS
- Product Name
- DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS
- CAS No.
- 27958-06-1
- Chemical Name
- DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS
- Synonyms
- SA 3097D1;deacetylanisomycin;DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS;3,4-Pyrrolidinediol, 2-[(4-methoxyphenyl)methyl]-, (2R,3S,4S)-
- CBNumber
- CB8498030
- Molecular Formula
- C12H17NO3
- Formula Weight
- 223.27
- MOL File
- 27958-06-1.mol
DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS Property
- Melting point:
- 176-179°
- alpha
- D25 -20.0° (methanol)
- Boiling point:
- 390.7±37.0 °C(Predicted)
- Density
- 1.233±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Methanol: soluble
- form
- A solid
- pka
- 9.2(at 25℃)
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 28067
- Product name
- Deacetylanisomycin
- Packaging
- 5mg
- Price
- $250
- Updated
- 2024/03/01
- Product number
- 28067
- Product name
- Deacetylanisomycin
- Packaging
- 25mg
- Price
- $750
- Updated
- 2024/03/01
- Product number
- D198978
- Product name
- Deacetylanisomycin
- Packaging
- 10mg
- Price
- $415
- Updated
- 2021/12/16
- Product number
- 257253
- Product name
- Deacetylanisomycin
- Packaging
- 2mg
- Price
- $426
- Updated
- 2021/12/16
- Product number
- API0010102
- Product name
- DEACETYLANISOMYCIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.07
- Updated
- 2021/12/16
DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS Chemical Properties,Usage,Production
Description
Deacetylanisomycin is a derivative of the protein and DNA synthesis inhibitor anisomycin with antimalarial and anticancer activity. It inhibits the growth of the P. falciparum strains K1 and T9-96 in vitro (IC50s = 40.29 and 33.57 μM, respectively). Deacetylanisomycin is cytotoxic to LU99 lung carcinoma and MCF-7 breast cancer cells (IC50s = 23 and 34 μM, respectively). It has been used as a negative control for assessment of protein synthesis inhibitor activity in molluscan neurons.
Uses
Agricultural fungicide.
Uses
Deacetylanisomycin is the core structure of a family of dihydroxypyrrolidines produced by several species of Streptomyces. Anisomycin esters are potent inhibitors of protein synthesis. While considered inactive, deacetylanisomycin is a potent growth regulator in plants and its underlying pharmacology is poorly researched. This is all the more significant as anisomycin undergoes facile hydrolysis to deacetylanisomycin in polar solvents in vitro, and in vivo.
Uses
Deacetylanisomycin is a potent inhibitor of protein synthesis.
References
[1] Y HOSOYA. Anisomycin and new congeners active against human tumor cell lines.[J]. Journal of Antibiotics, 1993, 46 8: 1300-1302. DOI: 10.7164/antibiotics.46.1300
[2] D L ALKON. Inhibition of protein synthesis prolongs Ca2+-mediated reduction of K+ currents in molluscan neurons.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1987, 84 19: 6948-6952. DOI: 10.1073/pnas.84.19.6948
DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS Preparation Products And Raw materials
Raw materials
Preparation Products
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