ChemicalBook > CAS DataBase List > GW311616A

GW311616A

Product Name
GW311616A
CAS No.
197890-44-1
Chemical Name
GW311616A
Synonyms
CS-1260;GW 311616A;GW-311616A;GW 311616A - GW 311616 hydrochloride;GW311616 hydrochloride,GW-311616 hydrochloride
CBNumber
CB8498151
Molecular Formula
C19H32ClN3O4S
Formula Weight
433.99
MOL File
197890-44-1.mol
More
Less

GW311616A Property

storage temp. 
2-8°C
solubility 
H2O: 24 mg/mL, soluble
form 
solid
color 
White to yellow
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
27957
Product name
GW 311616A
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
27957
Product name
GW 311616A
Packaging
10mg
Price
$396
Updated
2024/03/01
Cayman Chemical
Product number
27957
Product name
GW 311616A
Packaging
5mg
Price
$238
Updated
2024/03/01
Axon Medchem
Product number
Axon2364
Product name
GW311616A-GW311616hydrochloride
Purity
99%
Packaging
5mg
Price
$198
Updated
2021/12/16
ApexBio Technology
Product number
B4676
Product name
GW311616hydrochloride
Packaging
100mg
Price
$210
Updated
2021/12/16
More
Less

GW311616A Chemical Properties,Usage,Production

Description

GW 311616A is an inhibitor of neutrophil elastase (IC50 = 100 nM). It is selective for neutrophil elastase (IC50 = 22 nM for the human enzyme) over trypsin, cathepsin G, and plasmin (IC50s = >100 μM for all), as well as chymotrypsin and tissue plasminogen activator (IC50s = >3 μM for both), in cell-free assays. GW 311616A (20 μM) inhibits the formation of neutrophil extracellular traps (NETs) induced by phorbol 12-myristate 13-acetate (PMA; ) in isolated human neutrophils. It inhibits intraneutrophil elastase activity in isolated dog blood six hours after administration of a 0.22 mg/kg dose. GW 311616A also inhibits neutrophil elastase in the liver in a mouse model of liver ischemia-reperfusion injury when administered at a dose of 2 mg/kg.

References

[1] macdonald sj1, dowle md, harrison la, shah p, johnson mr, inglis gg, clarke gd, smith ra, humphreys d, molloy cr, amour a, dixon m, murkitt g, godward re, padfield t, skarzynski t, singh om, kumar ka, fleetwood g, hodgson st, hardy gw, finch h. the discovery of a potent, intracellular, orally bioavailable,long duration inhibitor of human neutrophil elastase-gw311616a a development candidate. bioorg med chem lett. 2001 apr 9;11(7):895-8.

GW311616A Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

GW311616A Suppliers

China 17 Switzerland 1 United States 10 Global 28
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32159
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38630
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Abcam Limited
Tel
--
Fax
--
Email
us.orders@abcam.com
Country
United States
ProdList
6001
Advantage
50
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Axon Medchem LLC
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
United States
ProdList
763
Advantage
58

197890-44-1, GW311616ARelated Search:


  • CS-1260
  • GW 311616A;GW-311616A
  • GW 311616A - GW 311616 hydrochloride
  • GW311616 hydrochloride,GW-311616 hydrochloride
  • 197890-44-1