DIBENZO(F H)QUINOXALINE

DIBENZO(F H)QUINOXALINE Property

Melting point:

180℃

Boiling point:

454.4±18.0 °C(Predicted)

Density 

1.291±0.06 g/cm3 (20 ºC 760 Torr)

storage temp. 

Sealed in dry,Room Temperature

pka

0.59±0.30(Predicted)

Appearance

Light brown to brown Solid

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

DIBENZO(F H)QUINOXALINE Chemical Properties,Usage,Production

Chemical Properties

light yellow powder

Synthesis

Under nitrogen protection, 18.6 g (0.31 mol) of ethylenediamine was dissolved with 55.0 g (0.26 mol) of 9,10-phenanthrenequinone in 1000 mL of toluene to form a red suspension. A manifold was installed and the reaction mixture was heated to reflux for 24 hours. Upon completion of the reaction, 50.0 g of manganese dioxide was added to the resulting brown suspension, and heating and refluxing was continued until thin layer chromatography (TLC) detection showed complete disappearance of the intermediate. The reaction mixture was filtered while hot and the solid residue was washed with 200 mL of toluene. The filtrates were combined and concentrated under reduced pressure, and the resulting solid was dried under vacuum to give 58.0 g of dibenzo[f,h]quinoxaline as a pale yellow solid in 97% yield.

References

[1] Patent: CN101970448, 2016, B. Location in patent: Paragraph 0381; 0382
[2] Recueil des Travaux Chimiques des Pays-Bas-Journal of the Royal Netherlands, 1996, vol. 115, # 5, p. 275 - 285
[3] Chemische Berichte, 1886, vol. 19, p. 112
[4] Chemische Berichte, 1887, vol. 20, p. 268
[5] Journal of the Chemical Society, 1889, vol. 55, p. 98