4-BOC-1-(5-BROMO-2-PYRIDYL)PIPERAZINE

Product Name: 4-BOC-1-(5-BROMO-2-PYRIDYL)PIPERAZINE
CAS No.: 153747-97-8
Chemical Name: 4-BOC-1-(5-BROMO-2-PYRIDYL)PIPERAZINE
Synonyms: Pabuxilibu impurity 6;Palbociclib impurity C;Palbociclib Impurity 114;2-(4-BOC-piperazino)-5-bromopyridine;4-BOC-1-(5-Bromopyridin-2-yl)piperazine;1-Boc-4-(5-bromo-2-pyridinyl)-piperazine;4-Boc-1-(5-bromo-2-pyridyl)piperazine 97%;5-Bromo-2-[4-(N-Boc)piperazin-1-yl]pyridine;Palbociclib Impurity C : Trifluoroacetic acid salt;t-Butyl 4-(5-bromopyridin-2-yl)piperazine-1-carboxylate
CBNumber: CB8498898
Molecular Formula: C14H20BrN3O2
Formula Weight: 342.23
MOL File: 153747-97-8.mol

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4-BOC-1-(5-BROMO-2-PYRIDYL)PIPERAZINE Property

Melting point:: 83-87 °C (lit.)
Boiling point:: 433.0±45.0 °C(Predicted)
Density: 1.372±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 6.06±0.29(Predicted)
form: Powder
color: White to yellow
Water Solubility: Soluble in water.
InChI: InChI=1S/C14H20BrN3O2/c1-14(2,3)20-13(19)18-8-6-17(7-9-18)12-5-4-11(15)10-16-12/h4-5,10H,6-9H2,1-3H3
InChIKey: DSLVSFMWCDGZIL-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCN(C2=NC=C(Br)C=C2)CC1

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38
Safety Statements: 26-36/37/39-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
HazardClass: 6.1
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 653764
Product name: 4-Boc-1-(5-bromo-2-pyridyl)piperazine
Purity: 97%
Packaging: 1g
Price: $51.8
Updated: 2023/06/20

Sigma-Aldrich

Product number: 653764
Product name: 4-Boc-1-(5-bromo-2-pyridyl)piperazine
Purity: 97%
Packaging: 5g
Price: $145
Updated: 2023/06/20

TRC

Product number: B663255
Product name: 2-(4-BOC-piperazino)-5-bromopyridine
Packaging: 250mg
Price: $55
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0024385
Product name: 4-(5-BROMO-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $244.65
Updated: 2021/12/16

Apolloscientific

Product number: OR8546
Product name: tert-Butyl4-(5-bromopyridin-2-yl)piperazine-1-carboxylate
Packaging: 5g
Price: $357
Updated: 2021/12/16

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4-BOC-1-(5-BROMO-2-PYRIDYL)PIPERAZINE Chemical Properties,Usage,Production

Uses

4-Boc-1-(5-bromo-2-pyridyl)piperazine is used as active pharmaceutical ingredient.

Synthesis

624-28-2

57260-71-6

153747-97-8

General procedure for the synthesis of 4-Boc-1-(5-bromo-2-pyridinyl)piperazine from 2,5-dibromopyridine and N-BOC-piperazine: 2,5-dibromopyridine (2 g, 10.7 mmol), sodium tert-butoxide (1.6 g, 16.6 mmol), xantphos (400 mg, 0.7 mmol) and toluene (100 mL) and purged with argon for 5 min. Subsequently, tert-butyl piperazine-1-carboxylate (3.4 g, 14.30 mmol) and Pd2(dba)3 (200 mg, 0.21 mmol) were added to the reaction system, and the reaction was heated at 80 °C for 4 h (TLC monitoring showed complete consumption of raw materials). Upon completion of the reaction, the reaction mixture was diluted with EtOAc (200 mL), water (100 mL) was added, filtered through a bed of diatomaceous earth, and the filter bed was washed with EtOAc (2 x 30 mL). The organic phases were combined, washed with brine (50 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (100-200 mesh, 50 g, 10-20% EtOAc-hexane gradient elution) to give tert-butyl 4-(5-bromo-2-pyridinyl)piperazine-1-carboxylate (3 g, 82%) as a yellow solid.LCMS (ESI+): m/z: 342.57 [M+H]+.

References

[1] Organic Letters, 2003, vol. 5, # 24, p. 4611 - 4614
[2] Patent: WO2018/125961, 2018, A1. Location in patent: Page/Page column 123
[3] Patent: WO2007/20888, 2007, A1. Location in patent: Page/Page column 45-46
[4] Patent: US2006/293310, 2006, A1. Location in patent: Page/Page column 5

4-BOC-1-(5-BROMO-2-PYRIDYL)PIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BOC-1-(5-BROMO-2-PYRIDYL)PIPERAZINE Suppliers

China 97 India 4 Switzerland 1 United Kingdom 1 United States 9 Global 112

Aloespharm Co., Ltd.

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View Lastest Price from 4-BOC-1-(5-BROMO-2-PYRIDYL)PIPERAZINE manufacturers

Career Henan Chemical Co

Product: 4-BOC-1-(5-BROMO-2-PYRIDYL)PIPERAZINE 153747-97-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100Kg
Release date: 2020-01-02

153747-97-8, 4-BOC-1-(5-BROMO-2-PYRIDYL)PIPERAZINERelated Search:

TERT-BUTYL 4-(5-BROMO-3-METHYLPYRIDIN-2-YL)-2-(S)-METHYLPIPERAZINE-1-CARBOXYLATE tert-Butyl 4-[5-bromo-3-(methoxycarbonyl)pyridin-2-yl]piperazine-1-carboxylate 5-Bromo-2-(4-Boc-piperazin-1-yl)-4-methylpyridine 5-BROMO-2-(4-BOC-PIPERAZIN-1-YL)-3-METHYLPYRIDINE 4-BOC-1-(5-BROMO-2-PYRIDYL)PIPERAZINE

1-Boc-4-(5-bromo-2-pyridinyl)-piperazine

5-Bromo-2-[4-(N-Boc)piperazin-1-yl]pyridine

1-Piperazinecarboxylic acid, 4-(5-bromo-2-pyridinyl)-, 1,1-dimethylethyl ester

2-(4-BOC-piperazino)-5-bromopyridine

t-Butyl 4-(5-bromopyridin-2-yl)piperazine-1-carboxylate

Palbociclib Impurity C : Trifluoroacetic acid salt

Palbociclib impurity C

4-Boc-1-(5-bromo-2-pyridyl)piperazine 97%

4-(5-Bromo-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

2-(N-Boc-piperazin-1-yl)-5-bromopyridine, tert-Butyl 4-(5μ-bromopyrid-2μ-yl)piperazine-1-carboxylate

Pabuxilibu impurity 6

ert-butyl4-(5-bromopyridin-2-yl)piperazine-1-carboxylate

4-BOC-1-(5-Bromopyridin-2-yl)piperazine

Palbociclib Impurity 114

153747-97-8

Organohalides

Pyridine

piperazines

pharmacetical

alkyl bromide