Antidepressants Pharmacological effects Health risk Patent cases Uses
ChemicalBook > CAS DataBase List > Agomelatine

Agomelatine

Antidepressants Pharmacological effects Health risk Patent cases Uses
Product Name
Agomelatine
CAS No.
138112-76-2
Chemical Name
Agomelatine
Synonyms
AGOMELATIN;Valdoxan;GOMELATINE;VALDOXAN; MELITOR; THYMANAX;omeL;atine;AgomeL;Melitor;CS-1963;S 20098
CBNumber
CB8500647
Molecular Formula
C15H17NO2
Formula Weight
243.3
MOL File
138112-76-2.mol
More
Less

Agomelatine Property

Melting point:
107-109°C
Boiling point:
478.8±28.0 °C(Predicted)
Density 
1.109±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >50mg/mL
form 
powder
pka
16.17±0.46(Predicted)
color 
white to off-white
Merck 
14,190
InChI
InChI=1S/C15H17NO2/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13/h3-7,10H,8-9H2,1-2H3,(H,16,17)
InChIKey
YJYPHIXNFHFHND-UHFFFAOYSA-N
SMILES
C(NCCC1=C2C(C=CC(OC)=C2)=CC=C1)(=O)C
CAS DataBase Reference
138112-76-2(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
N
Risk Statements 
50
Safety Statements 
61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
AC5956323
HS Code 
29241990
Toxicity
mouse,LD50,oral,> 1gm/kg (1000mg/kg),United States Patent Document. Vol. #5318994,
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A1362
Product name
Agomelatine
Purity
≥98% (HPLC)
Packaging
5mg
Price
$84.1
Updated
2024/03/01
Sigma-Aldrich
Product number
A1362
Product name
Agomelatine
Purity
≥98% (HPLC)
Packaging
25mg
Price
$357
Updated
2024/03/01
TCI Chemical
Product number
A2606
Product name
Agomelatine
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$355
Updated
2024/03/01
Cayman Chemical
Product number
13203
Product name
Agomelatine
Purity
≥98%
Packaging
5mg
Price
$76
Updated
2024/03/01
Cayman Chemical
Product number
13203
Product name
Agomelatine
Purity
≥98%
Packaging
10mg
Price
$142
Updated
2024/03/01
More
Less

Agomelatine Chemical Properties,Usage,Production

Antidepressants

Agomelatine, which is developed by the French Servier company, is the world's first melatonin receptors MT1 and MT2 agonist class of antidepressants. It applies to the treatment of adult patients with severe depressive. We know that melatonin is an endogenous neural hormones. It is only produced by the pineal gland anterior pituitary at night, and acts on the melatonin receptor that focuses on the presence of hypothalamic suprachiasmatic nucleus (SCN). It is involved in mediating the circadian rhythms in mammals. It is the well-known time guardian in the body, which can regulate the biological clock that is modulated by external circadian cycle. However, since that melatonin has high catabolism rate in vivo which mikes its half-life shorter and the selectivity of its receptor located in the SCN poorer, the treatment of circadian rhythms disorders is limited. Therefore, in order to overcome these drawbacks of melatonin, the researchers designed a series of melatonin analogues. Molecular modeling studies have shown that indole ring of melatonin is the structure sites of catabolic inactivation. Indole ring is an ideal site of isosteric modifications. Agomelatine developed by Servier company is melatonin’s naphthalene biological (electronic) isostere analogs. Indole ring is substituted by naphthalene nucleus, which leads it have more metabolic stability than melatonin.

Pharmacological effects

The listing of agomelatine is a new breakthrough in the field of the treatment of depression. It is melatonin MT1/MT2 receptor agonist and serotonin 2c (5-HT2C) receptor antagonist. It can make depressed patients’ biological rhythm disorders return to normal through the synergy between the two and then result in antidepressant efficacy. Its unique mechanism of action has opened up an innovative way to treat depression. Agomelatine’s mechanism of drug action is completely different with antidepressants that are commonly used today, such as selective serotonin reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRI). SSRI and SNRI antidepressants achieve antidepressant efficacy by increasing concentration of serotonin. But it also brings a lot of side effects, such as weight changes, sexual dysfunction, withdrawal syndrome and the like. The molecular structure of agomelatine directly combines with serotonin 2c (5HT2c) receptor of post-synaptic membrane so as to exert its antidepressant efficacy without increasing serotonin concentration in the synaptic cleft. This unique mechanism of action makes agomelatine quickly and effectively exert its antidepressant efficacy at the same time, and avoid the occurrence of adverse drug reactions to an extreme.
Another unique targets of agomelatine is in melatonin receptors. MT1 and MT2 receptors densely distribute in the human suprachiasmatic nucleus. The nucleus mainly control human sleep rhythm. Agomelatine can well improve the quality of patients’ sleep by agonism on MT1 MT2 receptors, and improve patients’ wakefulness during the day. The quality of sleep has both cause and effect relationship with depression outcomes state. It is reported that 80% of patients with depression have the problems of sleep disorders at different levels. The improvement of sleep quality can directly contribute to the improvement of the overall clinical condition of patients with depression.
The above information is edited by the Chemicalbook of Ge Qian.

Health risk

October 30, 2012, the British Medicines and Healthcare Products Agency (MHRA) released agomelatine (agomelatine, Valdoxan/Thymanax) security information. MHRA found that several cases appears serious reports of liver toxicity with agomelatine, including six cases of liver failure patients within worldwide report. Agomelatine's drug information already includes in the recommendations that all patients need liver function tests at the start of treatment and during treatment. Now liver function tests should also be recommended when the drug dose is increased. MHRA recommends that if the patients have potential liver damage symptoms or signs, or that the increases of serum transaminase beyond the upper limit of normal (ULN) three times is found in the function tests, it should be immediately suspended.

Patent cases

The earliest agomelatine compound patent is French Patent FR902393, which is applied in February 27, 1990. This patent has the same patent family in Europe, USA, Canada, Japan and Australia. But there is no Chinese patent. The above patents were all authorized after January 1, 1993. Therefore China is also ineligible for administrative protection. Agomelatine has both technology patent and polymorph patent in China. But it also can be avoided.

Uses

Melatonin drugs.

Description

Agomelatine is an agonist of melatonin (MT) receptors and a derivative of melatonin . It binds to MT1 and MT2 receptors (Kis = 0.14 and 0.41 nM, respectively) and has an EC50 value of 0.1 nM in a [35S]GTPγS binding assay using CHO cells expressing MT2 receptors. Agomelatine is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT2B and 5-HT2C (Kis = 0.26 and 0.71 nM, respectively, for the human receptors). Agomelatine (40 mg/kg) inhibits the penile erection response induced by the 5-HT2 agonist Ro 60-0175 in rats. It also increases extracellular levels of noradrenaline and dopamine in the frontal cortex of freely moving rats when administered at doses ranging from 20 to 80 mg/kg. Agomelatine (10 mg/kg) reduces immobility time in the forced swim test and increases the amount of time spent in the open arms of the elevated plus maze in mice, indicating antidepressant-like and anxiolytic-like activity, in a transgenic neuroendocrine model of depression. It also increases the rate of readjustment to circadian activity cycles following an induced phase shift.

Chemical Properties

White Solid

Uses

Agomelatine is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C receptors, respectively.

Uses

Agomelatine has been used:

  • to study its effects on adult neurogenesis and hippocampus apoptosis using the stress-induced depression model of rats
  • to explore its effects on tau protein phosphorylation and to study its neuroprotective mechanism
  • to study its effects on intracellular calcium ([Ca2+]i) signaling in peripheral neurons of rat dorsal root ganglion (DRG) neurons

Uses

Agomelatine is an antidepressant drug. It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of

Definition

ChEBI: Agomelatine is a member of acetamides.

Biochem/physiol Actions

Agomelatine is an extremely potent agonist at both melatonin receptors (MT1 and MT2), with additional antagonism at 5HT2C. It is a novel antidepressant with many desired in vivo properties, including neuroprotection and neurogenesis in depression-sensitive brain areas. Agomelatine′s efficacy appears to be due to both melatonergic and serotonergic properties. In neurogenesis assays, both in vitro and in vivo, the compound effects were differentially affected by antagonists for MT1/MT2 and 5HT2C, demonstrating actions through all three receptors.

Clinical Use

Antidepressant

target

TNF-α | IL Receptor | P450 (e.g. CYP17) | 5-HT Receptor

Drug interactions

Potentially hazardous interactions with other drugs
Antibacterials: avoid with ciprofloxacin.
Antidepressants: metabolism inhibited by fluvoxamine.
Antimalarials: avoid with artemether with lumefantrine and artenimol with piperaquine.

Metabolism

Agomelatine is rapidly metabolised, mainly by the hepatic cytochrome P450 isoenzyme CYP1A2; the isoenzymes CYP2C9 and CYP2C19 also make a minor contribution. The major metabolites, hydroxylated and demethylated agomelatine, are not active and are rapidly conjugated and eliminated in the urine.

References

[1] zupancic m, guilleminault c. agomelatine. cns drugs, 2006, 20(12): 981-992.

Agomelatine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Agomelatine Suppliers

Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Sequoia Research Products Limited
Tel
--
Fax
--
Email
info@seqchem.com
Country
United Kingdom
ProdList
162
Advantage
58
Melrob Ltd (part of Nordmann)
Tel
--
Fax
--
Email
nquiries@melrob.com
Country
United Kingdom
ProdList
3065
Advantage
58
CMS Chemicals Limited
Tel
--
Fax
--
Email
cms.marketing@cms-chemicals.com
Country
United Kingdom
ProdList
3708
Advantage
60
KEMPROTEC Limited
Tel
--
Fax
--
Email
enquiries@kemprotec.com
Country
United Kingdom
ProdList
495
Advantage
47
Sequoia Research Products Ltd.
Tel
--
Fax
--
Email
sales@seqchem.com
Country
United Kingdom
ProdList
3113
Advantage
69
Molekula Ltd
Tel
--
Fax
--
Email
info@molekula.com
Country
United Kingdom
ProdList
4060
Advantage
50
More
Less

View Lastest Price from Agomelatine manufacturers

Dorne Chemical Technology co. LTD
Product
AGOMELATINE 138112-76-2
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1 tons
Release date
2024-03-26
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Agomelatine 138112-76-2
Price
US $99.00-66.00/kg
Min. Order
0.0010000000474974513kg
Purity
99%
Supply Ability
5000
Release date
2024-08-19
Shanghai Affida new material science and technology center
Product
Agomelatine 138112-76-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99
Supply Ability
20tons
Release date
2024-05-08

138112-76-2, AgomelatineRelated Search:


  • Melitor
  • VALDOXAN; MELITOR; THYMANAX
  • CS-1963
  • AgoMelatine(S-20098,Valdoxan)
  • S20098,N-[2-(7-Methoxynaphth-1-yl)ethyl]acetamide
  • S 20098
  • AGOMELATIN
  • Acetamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)-
  • Unii-137R1N49ad
  • Valdoxan
  • Agomelatine, >=99%
  • Agomelatine (Form I,II )
  • Thymanax
  • AGOMELATINE
  • n-(2-(7-methoxy-1-naphthalenyl)ethyl)-acetamid
  • n-(2-(7-methoxy-1-naphthalenyl)ethyl)acetamide
  • n-(2-(7-methoxynaphth-1-yl)ethyl)acetamide
  • Agomelatine S20098,N-[2-(7-Methoxynaphth-1-yl)ethyl]acetamide
  • Agomelatine, 99%, a competitive antagonist of (5-HT2C) receptors
  • Agomelantine
  • Agomelatine API
  • Agomelatine &gt
  • Agomelatine Agomelatine
  • atine
  • omeL
  • AgomeL
  • AGOMELATINE USP/EP/BP
  • GOMELATINE
  • Agomelatine (S-20098
  • BAN, rINN
  • AgomelatineQ: What is Agomelatine Q: What is the CAS Number of Agomelatine Q: What is the storage condition of Agomelatine Q: What are the applications of Agomelatine
  • Agomelatine 138112-76-2
  • N-(2-(7-methoxynaphthalen-1-yl)ethyl)acetamide( Agomelatin)
  • 1-(2-acetamidoethyl)naphthalen-7-yl acetate (Agomelatine)
  • Agomelatine, mixed 2-crystal form
  • Thymanax|||S-20098|||Valdoxan
  • Agomelatine in methanol
  • 138112-76-2
  • 138112-08-2
  • APIS
  • Aromatics Compounds
  • Aromatics
  • Neurochemicals
  • Agomelatine
  • API
  • Valdoxan, Melitor, Thymanax
  • 138112-76-2