3-FLUORO-4-IODOBENZONITRILE
Uses- Product Name
- 3-FLUORO-4-IODOBENZONITRILE
- CAS No.
- 887266-99-1
- Chemical Name
- 3-FLUORO-4-IODOBENZONITRILE
- Synonyms
- CAS:887266-99-1;Fluoro-4-ioxynil;5-Fluoro-4-iodobenzonitrile;4-Cyano-2-fluoroiodobenzene;3-FLUORO-4-IODOBENZONITRILE3;Benzonitrile, 3-fluoro-4-iodo-
- CBNumber
- CB8501194
- Molecular Formula
- C7H3FIN
- Formula Weight
- 247.01
- MOL File
- 887266-99-1.mol
3-FLUORO-4-IODOBENZONITRILE Property
- Melting point:
- 113-117 °C
- Boiling point:
- 268℃
- Density
- 1.98
- Flash point:
- 116℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- color
- Light yellow to Brown
- Sensitive
- Light Sensitive
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- WGK Germany
- 3
- Hazard Note
- Harmful
- HazardClass
- IRRITANT, IRRITANT-HARMFUL
- HS Code
- 29269090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 678899
- Product name
- 3-Fluoro-4-iodobenzonitrile
- Purity
- 97%
- Packaging
- 1g
- Price
- $78.28
- Updated
- 2025/07/31
- Product number
- F1093
- Product name
- 3-Fluoro-4-iodobenzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $69
- Updated
- 2025/07/31
- Product number
- F592113
- Product name
- 3-Fluoro-4-iodobenzonitrile
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- F592113
- Product name
- 3-Fluoro-4-iodobenzonitrile
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- PC9581
- Product name
- 3-Fluoro-4-iodobenzonitrile
- Packaging
- 5g
- Price
- $22
- Updated
- 2021/12/16
3-FLUORO-4-IODOBENZONITRILE Chemical Properties,Usage,Production
Uses
3-Fluoro-4-iodobenzonitrile is a halocarbon compound, mainly used as a chemical and pharmaceutical intermediate.
Chemical Properties
Type of white crystal
Synthesis
63069-50-1
887266-99-1
The general procedure for the synthesis of 3-fluoro-4-iodobenzonitrile from 3-fluoro-4-aminobenzonitrile was as follows: a mixture of 4-amino-3-fluorobenzonitrile (5.0 g, 36.76 mmol) with 4-toluenesulfonic acid (20.0 g, 105.2 mmol) in acetonitrile (50 mL) was stirred for 4 hours at room temperature. Subsequently, an aqueous solution of NaNO2 (3.8 g, 55.07 mmol) and KI (9.15 g, 55.07 mmol) was slowly added at 0 °C and stirring was continued for 1 hour. After completion of the reaction, the reaction mixture was quenched with ice water, washed sequentially with aqueous NaHSO3 and extracted with EtOAc. The organic layer was washed with water and brine, dried with Na2SO4 and concentrated under reduced pressure to give 4.0 g of the target product 3-fluoro-4-iodobenzonitrile. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.94-7.89 (t, J = 8.4 Hz, 1H), 7.34-7.32 (d, J = 7.5 Hz, 1H), 7.21-7.19 (d, J = 8.1 Hz, 1H).
References
[1] Patent: WO2016/55947, 2016, A1. Location in patent: Page/Page column 57
[2] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 23-24, p. 3766 - 3773
3-FLUORO-4-IODOBENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-FLUORO-4-IODOBENZONITRILE manufacturers
- Product
- 3-FLUORO-4-IODOBENZONITRILE 887266-99-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-11