THIETHYLPERAZINE MALATE (200 MG) Property

Melting point:

139°

storage temp. 

-20°C Freezer

solubility 

DMSO (Slightly)

form 

Solid

color 

White

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

THIETHYLPERAZINE MALATE (200 MG) Chemical Properties,Usage,Production

Originator

Torecan,Boehringer Ingelheim,US,1961

Uses

Thiethylperazine Dimalate is used as an anti-emetic drug specifically during pregnancy. Also a potent inhibitory agent against Enterococcus faecalis, a streptococcus Group D compound. Antibacterial.

Uses

Torecan (Novartis).

Manufacturing Process

26.1 parts of 3-ethylmercapto-phenothiazine (melting point 95°C to 97°C), 4.7 parts of finely pulverized sodium amide and 120 parts by volume of absolute xylene are heated to boiling for two hours, under reflux and while stirring the reaction mixture, at an oil-bath temperature of 180°C. Without interrupting the heating, a solution of 20.0 parts of 1-methyl-4-(3'- chloropropyl-1')-piperazine (boiling point 95°C to 97°C at a pressure of 10 mm Hg) in 20 parts by volume of xylene is added dropwise in the course of 1 1/2 hours. After heating 3 more hours, the reaction mixture is cooled and 10.0 parts of ammonium chloride added; the mixture is then shaken out three times, using 50 parts by volume of water each time. The xylene solution is extracted with 250 parts by volume of aqueous tartaric acid of 15% strength, after which the tartaric acid extract is washed with 80 parts by volume of benzene and then rendered phenolphthalein-alkaline by the addition of 60 parts by volume of concentrated aqueous caustic soda solution. The base which precipitates is taken up in a total of 150 parts by volume of benzene; the benzene layer is dried over potassium carbonate and is then evaporated under reduced pressure. The residue from the evaporation is distilled in a high vacuum. After separating a preliminary distillate which passes over up to 226°C under a pressure of 0.01 mm Hg the main fraction - 3-ethylmercapto- 10-[3'-(1''-methyl-piperazyl-4'')-propyl-1']-phenothiazine - which distills at 226°C to 228°C under the last-mentioned pressure is collected. The analytically pure base boils at 227°C under a pressure of 0.01 mm Hg and melts at 62°C to 64°C.
Upon the addition of ethanolic HCl to a solution, cooled to 0°C, of 26.38 parts of the free base in 130 parts by volume of absolute ethanol, until a Congoacid reaction is achieved, the crystalline dihydrochloride of 3-ethylmercapto- 10-[3'-(1''-methyl-piperazyl-4'')-propyl-1']phenothiazine is precipitated. The analytically pure salt has a melting point of 214°C to 216°C (bubbles); it begins to sinter at 205°C. The dimaleate melts at 188°C to 190°C after sintering from 180°C (recrystallized from methanol).

brand name

Thietylperazine Malate is JAN.

Therapeutic Function

Antiemetic