ChemicalBook > CAS DataBase List > BAX INHIBITING PEPTIDE V5 (BIP-V5)
BAX INHIBITING PEPTIDE V5 (BIP-V5)
- Product Name
- BAX INHIBITING PEPTIDE V5 (BIP-V5)
- CAS No.
- 579492-81-2
- Chemical Name
- BAX INHIBITING PEPTIDE V5 (BIP-V5)
- Synonyms
- Val-Pro-Met-Leu-Lys;VAL-PRO-MET-LEU-LYS;BIP-V5;Bax inhibitor peptide V5 TFA;BAX INHIBITOR PEPTIDE V5, >99%;Bax inhibitor peptide V5 (BIP-V5);BAX INHIBITING PEPTIDE V5 (BIP-V5);L-Lysine, L-valyl-L-prolyl-L-methionyl-L-leucyl-;VAL-PRO-MET-LEU-LYS;BIP-V5;BAX INHIBITING PEPTIDE V5;BAX Inhibiting Peptide V5 >=97% (HPLC), lyophilized powder;Bax inhibitor peptide V5，Val-Pro-Met-Leu-Lys， BIP-V5，BAX Inhibiting Peptide V5
- CBNumber
- CB8503178
- Molecular Formula
- C27H50N6O6S
- Formula Weight
- 586.79
- MOL File
- 579492-81-2.mol
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BAX INHIBITING PEPTIDE V5 (BIP-V5) Property
- Boiling point:
- 907.2±65.0 °C(Predicted)
- Density
- 1.185±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- ≥29.35 mg/mL in DMSO; insoluble in EtOH; ≥91.4 mg/mL in H2O
- form
- lyophilized powder
- pka
- 3.31±0.10(Predicted)
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- B1436
- Product name
- BAX Inhibiting Peptide V5
- Purity
- ≥97% (HPLC), lyophilized powder
- Packaging
- 5mg
- Price
- $188
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30243
- Product name
- Bax Inhibitor Peptide V5
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30243
- Product name
- Bax Inhibitor Peptide V5
- Packaging
- 10mg
- Price
- $308
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30243
- Product name
- Bax Inhibitor Peptide V5
- Packaging
- 5mg
- Price
- $163
- Updated
- 2024/03/01
TRC
- Product number
- B129293
- Product name
- BaxInhibitorPeptideV5
- Packaging
- 10mg
- Price
- $495
- Updated
- 2021/12/16
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BAX INHIBITING PEPTIDE V5 (BIP-V5) Chemical Properties,Usage,Production
Description
Bax inhibitor peptide V5 is an inhibitor of Bax. It decreases levels of the pro-apoptotic proteins Bax, Bad, and NF-ĸB p65 and increases levels of the anti-apoptotic proteins X-linked inhibitor of apoptosis (XIAP) and Bcl-2 in isolated mouse pancreatic islets when used at a concentration of 100 μM. It inhibits apoptosis induced by etoposide in Hep3B human hepatoma cells when used at a concentration of 200 μM. Bax inhibitor peptide V5 (5 mg/ml, i.c.v.) decreases infarct volume and reduces ipsilateral paw preference in the cylinder rearing test, indicating an improvement in sensorimotor function, in a neonatal mouse model of hypoxic-ischemia brain injury induced by carotid artery ligation. Bax inhibitor peptide V5, when used at a concentration of 100 μM in syngeneic pancreatic islet cells prior to transplantation, inhibits increases in blood glucose levels in an intraperitoneal glucose tolerance test and increases survival in a mouse model of diabetes induced by streptozotocin (STZ; ).
Biochem/physiol Actions
BAX Inhibiting Peptide V5 protects Bax against conformational changes and it also prevents mitochondrial translocation. In vitro analysis prove that peptide V5 prevents apoptosis, mediated by a number of agents including staurosporine, ultraviolet and anti-cancer drug.
References
[1]. sawada m, hayes p, matsuyama s. cytoprotective membrane-permeable peptides designed from the bax-binding domain of ku70. nat cell biol, 2003, 5(4): 352-357.
[2]. rivas-carrillo jd, soto-gutierrez a, navarro-alvarez n, et al. cell-permeable pentapeptide v5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. diabetes, 2007, 56(5): 1259-1267.
BAX INHIBITING PEPTIDE V5 (BIP-V5) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BAX INHIBITING PEPTIDE V5 (BIP-V5) manufacturers
Career Henan Chemical Co
- Product
- BAX INHIBITING PEPTIDE V5 (BIP-V5) 579492-81-2
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-18