LY-53 857 MALEATE
- Product Name
- LY-53 857 MALEATE
- CAS No.
- 60634-51-7
- Chemical Name
- LY-53 857 MALEATE
- Synonyms
- LY 53857;ly-53,857 maleate salt;6-methyl-1-(1-methylethyl)ergoline-8β-carboxylic acid 2-hydroxy-1-methylpropyl ester maleate salt
- CBNumber
- CB8503734
- Molecular Formula
- C27H36N2O7
- Formula Weight
- 500.59
- MOL File
- 60634-51-7.mol
LY-53 857 MALEATE Property
- solubility
- 0.1 M HCl: 25 mg/mL
- form
- solid
- color
- white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- BRS0000558
- Product name
- LY-53857
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.43
- Updated
- 2021/12/16
LY-53 857 MALEATE Chemical Properties,Usage,Production
Uses
LY53857 is a potent antagonist of vasoconstriction and serotonin-mediated 5-HT2 receptors. LY53857 did not reduce mean arterial blood pressure in spontaneously hypertensive rats (SHR) at doses that blocked the depressor response to serotonin and blocked central serotonin receptors. In addition, LY53857 was able to enhance neurotransmitter release in rat vas deferens and guinea pig ileal nerves[1].
References
[1] Cohen M L, et al. LY53857, a selective and potent serotonergic (5-HT2) receptor antagonist, does not lower blood pressure in the spontaneously hypertensive rat[J]. Journal of Pharmacology and Experimental Therapeutics, 1983, 227(2): 327-332. PMID:6313898
[2] Cohen M L, et al. Receptor specificity of the 5HT2 receptor antagonist, LY53857[J]. Drug development research, 1985, 5(4): 313-321.
LY-53 857 MALEATE Preparation Products And Raw materials
Raw materials
Preparation Products
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