2,2'-Bipyridine-4,4'-dicarboxaldehyde
Uses Application- Product Name
- 2,2'-Bipyridine-4,4'-dicarboxaldehyde
- CAS No.
- 99970-84-0
- Chemical Name
- 2,2'-Bipyridine-4,4'-dicarboxaldehyde
- Synonyms
- 2-Bromo-9-methoxybenzoicacid;2,2'-Bipyridyl-4,4'-dicarboxaldehyde;2,2']bipyridinyl-4,4'-dicarbaldehyde;2,2'-bipyridine]-4,4'-dicarbaldehyde;2 2'-BIPYRIDINE-4 4'-DICARBOXALDEHYDE;[2,2']bipyridinyl-4,4'-dicarbaldehyde;2,2'-Bipyridine-4,4'-dicarboxaldehyde 95%
- CBNumber
- CB8504261
- Molecular Formula
- C12H8N2O2
- Formula Weight
- 212.2
- MOL File
- 99970-84-0.mol
2,2'-Bipyridine-4,4'-dicarboxaldehyde Property
- Melting point:
- 188 °C (dec.)(lit.)
- Boiling point:
- 434.4±45.0 °C(Predicted)
- Density
- 1.289±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.03±0.30(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C12H8N2O2/c15-7-9-1-3-13-11(5-9)12-6-10(8-16)2-4-14-12/h1-8H
- InChIKey
- UJCACAOPZBJKIW-UHFFFAOYSA-N
- SMILES
- C1(C2=NC=CC(C=O)=C2)=NC=CC(C=O)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 474665
- Product name
- 2,2′-Bipyridine-4,4′-dicarboxaldehyde
- Purity
- 95%
- Packaging
- 500mg
- Price
- $373
- Updated
- 2023/01/07
- Product number
- B399300
- Product name
- 2,2''-Bipyridine-4,4''-dicarboxaldehyde
- Packaging
- 25mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- B399300
- Product name
- 2,2''-Bipyridine-4,4''-dicarboxaldehyde
- Packaging
- 100mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- CS-W018416
- Product name
- [2,2'-Bipyridine]-4,4'-dicarbaldehyde
- Purity
- 98.13%
- Packaging
- 1g
- Price
- $235
- Updated
- 2021/12/16
- Product number
- 057360
- Product name
- 2,2'-Bipyridine-4,4'-dicarbaldehyde
- Purity
- 95%
- Packaging
- 1g
- Price
- $288
- Updated
- 2021/12/16
2,2'-Bipyridine-4,4'-dicarboxaldehyde Chemical Properties,Usage,Production
Uses
2,2'-Bipyridine-4,4'-dicarboxaldehyde is an aldehyde organic compound used as an organic synthesis intermediate and a pharmaceutical intermediate. It can be used in laboratory organic synthesis processes and chemical and pharmaceutical research and development processes.
Application
2,2'-Bipyridine-4,4'-dicarboxaldehyde is an aldehyde organic compound used as an intermediate in organic synthesis.
General Description
2,2′-Bipyridine-4,4′-dicarboxaldehyde is an organic building block.
Synthesis
1134-35-6
99970-84-0
General procedure for the synthesis of 2,2'-bipyridine-4,4'-dialdehyde from 4,4'-dimethyl-2,2'-bipyridine: To a 100 mL two-necked round-bottomed flask was added 4,4'-dimethyl-2,2'-bipyridine (500 mg, 0.00271 mol, 1.0 eq.) 100 mL of 1,4-dioxane was added drop-wise with stirring until complete solubilization. Subsequently, the system was bubbled with nitrogen for 15 minutes to remove oxygen from the system. Selenium dioxide (0.663 mg, 2.2 eq.) was added under nitrogen protection and reacted under reflux conditions for 44 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was washed 2 to 3 times with warm 1,4-dioxane, filtered, and 1,4-dioxane was evaporated under reduced pressure. The residue was dissolved in hot distilled ethyl acetate, filtered and washed with hot ethyl acetate. The ethyl acetate layer was washed with 1 M sodium carbonate solution (250 mL) to remove residual carboxylic acid. The organic layer was dried with anhydrous sodium sulfate, concentrated, and the residue was purified by alumina column chromatography with the eluent being a 60% petroleum ether solution of ethyl acetate to give the target product 2,2'-bipyridine-4,4'-dialdehyde. The products were characterized by infrared spectroscopy (IR), nuclear magnetic resonance hydrogen spectroscopy (1H NMR), nuclear magnetic resonance carbon spectroscopy (13C NMR) and high resolution mass spectrometry (HRMS).
References
[1] Tetrahedron Letters, 2015, vol. 56, # 43, p. 5920 - 5923
[2] Organic Letters, 2002, vol. 4, # 17, p. 2857 - 2859
[3] New Journal of Chemistry, 2001, vol. 25, # 12, p. 1553 - 1566
[4] Synthesis, 2003, # 4, p. 577 - 583
[5] Tetrahedron Letters, 1996, vol. 37, # 42, p. 7503 - 7506
2,2'-Bipyridine-4,4'-dicarboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,2'-Bipyridine-4,4'-dicarboxaldehyde manufacturers
- Product
- 2,2'-Bipyridine-4,4'-dicarbaldehyde 99970-84-0
- Price
- US $46.00-309.00/g
- Min. Order
- 1g
- Purity
- 0.98
- Supply Ability
- 1kg
- Release date
- 2024-04-12
- Product
- 2 2'-BIPYRIDINE-4 4'-DICARBOXALDEHYDE 99970-84-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 25kg
- Release date
- 2019-07-11