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TMPH HYDROCHLORIDE

Product Name
TMPH HYDROCHLORIDE
CAS No.
849461-91-2
Chemical Name
TMPH HYDROCHLORIDE
Synonyms
TMPH HCl
CBNumber
CB8505046
Molecular Formula
C16H32ClNO2
Formula Weight
305.89
MOL File
849461-91-2.mol
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TMPH HYDROCHLORIDE Property

storage temp. 
2-8°C
solubility 
H2O: 22 mg/mL at ~60 °C
form 
solid
color 
white
Water Solubility 
H2O: 22mg/mL at~60°C
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-43
Safety Statements 
26-36/37
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T5576
Product name
TMPH hydrochloride
Purity
solid, (Product is pure based on CHN, NMR and MS results)
Packaging
5mg
Price
$228
Updated
2024/03/01
Sigma-Aldrich
Product number
T5576
Product name
TMPH hydrochloride
Purity
solid, (Product is pure based on CHN, NMR and MS results)
Packaging
25mg
Price
$727
Updated
2022/05/15
TRC
Product number
T460013
Product name
TMPH hydrochloride
Packaging
5mg
Price
$135
Updated
2021/12/16
ApexBio Technology
Product number
B7053
Product name
TMPH hydrochloride
Packaging
10mg
Price
$219
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008363
Product name
TMPH HYDROCHLORIDE
Purity
95.00%
Packaging
10MG
Price
$660.95
Updated
2021/12/16
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TMPH HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

TMPH Hydrochloride is a potent inhibitor of neuronal AChRs. Therapeutic agent potentially used for the treatment of this progressive neurodegenerative disease such as globoid cell leukodystrophy (GLD) or Krabbe disease.

Biological Activity

2,2,6,6-tetramethylpiperidin-4-yl heptanoate (TMPH) is a potent inhibitor of neuronal nicotinic receptors. Evaluation of nicotinic acetylcholine receptor (nAChR) subunits expressed in Xenopus laevis oocytes indicated th at TMPH can produce a potent and long-lasting inhibition of neuronal nAChR formed by the pairwise combination of the most abundant neuronal alpha (i.e., alpha3 and alpha4) and beta subunits (beta2 and beta4), with relatively little effect, because of rapid reversibility of inhibition, on muscle-type (alpha1beta1gammadelta) or alpha7 receptors. However, the inhibition of neuronal beta subunit-containing receptors was also decreased if any of the nonessential subunits alpha5, alpha6, or beta3 were coexpressed. This decrease in inhibition is shown to be associated with a single amino acid present in the second transmembrane domain of these subunits. TMPH abilitty to relate the diverse central nervous system effects to specific nAChR subtypes makes it a useful tool for studying the functional roles of nAChR.

TMPH HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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TMPH HYDROCHLORIDE Suppliers

China 11 Switzerland 1 United Kingdom 1 United States 5 Global 18
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7348
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
0519-85788828 13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3600
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Changzhou Furuisi Biotechnology Co., Ltd
Tel
0519-85524369
Email
3477467573@qq.com
Country
China
ProdList
8617
Advantage
58
Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3021
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24641
Advantage
58
SuZhou GoodChemTech Co., Ltd
Tel
18136139868
Email
jinlun@goodchemtech.cn
Country
China
ProdList
243
Advantage
58
Merck KGaA
Tel
(+86) 21 2033 8288
Email
sigmaname@qq.com
Country
CHINA
ProdList
292362
Advantage
58
Nantong HI-FUTURE Biology Co., Ltd.
Tel
+undefined18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3135
Advantage
58
Guangzhou WeiBo Chemical Co., Ltd.
Tel
--
Fax
--
Email
weibochem@163.com
Country
China
ProdList
6187
Advantage
67

849461-91-2, TMPH HYDROCHLORIDERelated Search:


  • TMPH HCl
  • 849461-91-2
  • C16H32ClNO2