2-AMINO-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXAMIDE

Product Name: 2-AMINO-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXAMIDE
CAS No.: 40106-12-5
Chemical Name: 2-AMINO-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXAMIDE
Synonyms: NSC727447;2-Amino-4H,5H,6H,7H,8H-cyclohepta[b]thiophene-3-carboxamide;2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-3-carboxamide;2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiophene-3-carboxamide
CBNumber: CB8511834
Molecular Formula: C10H14N2OS
Formula Weight: 210.3
MOL File: 40106-12-5.mol

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2-AMINO-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXAMIDE Property

Melting point:: 154-156 °C(Solv: ethanol (64-17-5))
Boiling point:: 347.5±42.0 °C(Predicted)
Density: 1.278±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: >10mg/mL
form: Solid
pka: 15.70±0.20(Predicted)
color: Light brown to brown

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N8164
Product name: NSC727447
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $357
Updated: 2025/07/31

Sigma-Aldrich

Product number: N8164
Product name: NSC727447
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $96.3
Updated: 2022/05/15

Biosynth Carbosynth

Product number: FA113320
Product name: 2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Packaging: 500mg
Price: $200
Updated: 2021/12/16

AK Scientific

Product number: 2592AE
Product name: 2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta-[b]thiophene-3-carboxamide
Packaging: 100mg
Price: $216
Updated: 2021/12/16

AK Scientific

Product number: 2592AE
Product name: 2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta-[b]thiophene-3-carboxamide
Packaging: 250mg
Price: $253
Updated: 2021/12/16

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2-AMINO-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXAMIDE Chemical Properties,Usage,Production

Uses

NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but great selectivity over human Rnase H, with IC50s value of 2.0 μM, 2.5 μM, 100 μM, 10.6 μM, respectively[1].

Biological Activity

NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but gre at selectivity over human Rnase H.

References

[1] Michaela Wendeler, et al. Vinylogous Ureas as a Novel Class of Inhibitors of Reverse Transcriptase-Associated Ribonuclease H Activity. ACS Chem Biol. 2008 Oct 17;3(10):635-44. DOI:10.1021/cb8001039

2-AMINO-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXAMIDE Suppliers

China 19 Ukraine 1 United Kingdom 1 United States 5 Global 26

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40106-12-5, 2-AMINO-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXAMIDERelated Search:

2-AMINO-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXAMIDE ART-CHEM-BB B014605 ART-CHEM-BB B014606 2-AMINO-N-(3-CHLOROPHENYL)-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXAMIDE ART-CHEM-BB B014614 ART-CHEM-BB B014609 ART-CHEM-BB B014608 2-amino-N-ethyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide AKOS 92539 ART-CHEM-BB B014610 din-4-one ART-CHEM-BB B014611 2-amino-N-methyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide ART-CHEM-BB B014612

NSC727447

2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiophene-3-carboxamide

2-Amino-4H,5H,6H,7H,8H-cyclohepta[b]thiophene-3-carboxamide

2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-3-carboxamide

40106-12-5