GS-441524 sodium
- Product Name
- GS-441524 sodium
- CAS No.
- 1355050-21-3
- Chemical Name
- GS-441524 sodium
- Synonyms
- GS-441524 sodium;GS-443902 trisodium;Remdesivirmetabolitetrisodium;GS-441524triphosphatetrisodium;Remdesivir Impurity 11(GS-441524 sodium)
- CBNumber
- CB85466355
- Molecular Formula
- C12H17N5NaO13P3
- Formula Weight
- 555.2
- MOL File
- 1355050-21-3.mol
GS-441524 sodium Property
- form
- Solid
- color
- White to light yellow
N-Bromosuccinimide Price
- Product number
- CS-0127566
- Product name
- GS-443902(trisodium)
- Purity
- 98.15%
- Packaging
- 1mg
- Price
- $980
- Updated
- 2021/12/16
- Product number
- CS-0127566
- Product name
- GS-443902(trisodium)
- Purity
- 98.15%
- Packaging
- 5mg
- Price
- $1950
- Updated
- 2021/12/16
- Product number
- CS-0127566
- Product name
- GS-443902(trisodium)
- Purity
- 98.15%
- Packaging
- 10mg
- Price
- $2950
- Updated
- 2021/12/16
GS-441524 sodium Chemical Properties,Usage,Production
Uses
GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734)[1][2].
in vivo
Remdesivir (GS-5734; 10mgkg; i.v.) rapidly distributes into peripheral blood mononuclear cells (PBMCs), and efficient conversion to GS-443902 trisodium (Remdesivir metabolite trisodium; NTP) is apparent within 2h of dose administration in rhesus monkeys. In PBMCs, GS-443902 trisodium represents the predominant metabolite and is persistent with a t1/2 of 14h and levels required for >50% virus inhibition for 24hours[3].
References
[1] Siegel D, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. Med Chem. 2017 Mar 9;60(5):1648-1661. DOI:10.1021/acs.jmedchem.6b01594
[2] Warren TK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17;531(7594):381-5. DOI:10.1038/nature17180
[3] Cho A, et al. Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7. DOI:10.1016/j.bmcl.2012.02.105
GS-441524 sodium Preparation Products And Raw materials
Raw materials
Preparation Products
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