LML-134
- Product Name
- LML-134
- CAS No.
- 1542135-76-1
- Chemical Name
- LML-134
- Synonyms
- LML-134;LML134, 10 mM in DMSO;inhibit,LML134,LML 134,Inhibitor,Histamine Receptor;1-Piperazinecarboxylic acid, 4-cyclobutyl-, 1-(1,6-dihydro-1-methyl-6-oxo-3-pyridazinyl)-4-piperidinyl ester
- CBNumber
- CB85476530
- Molecular Formula
- C19H29N5O3
- Formula Weight
- 375.47
- MOL File
- 1542135-76-1.mol
LML-134 Property
- Boiling point:
- 509.1±60.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 12.5 mg/mL (33.29 mM)
- pka
- 7.49±0.70(Predicted)
- form
- Solid
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- CS-0096400
- Product name
- LML134
- Purity
- 99.83%
- Packaging
- 25mg
- Price
- $990
- Updated
- 2021/12/16
- Product number
- CS-0096400
- Product name
- LML134
- Purity
- 99.83%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2021/12/16
- Product number
- CS-0096400
- Product name
- LML134
- Purity
- 99.83%
- Packaging
- 100mg
- Price
- $2250
- Updated
- 2021/12/16
- Product number
- CS-0096400
- Product name
- LML134
- Purity
- 99.83%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0096400
- Product name
- LML134
- Purity
- 99.83%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
LML-134 Chemical Properties,Usage,Production
Uses
LML134 (compound 18b) is an orally active and high selective Histamine 3 receptor (H3R) inverse agonist with Kis of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly, leading to high H3R occupancy, and disengages its target with a fast kinetic profile. LML134 has the potential for excessive sleep disorders[1].
in vivo
LML134 (compound 18b) (oral; 10 mg/kg) indicates rapid oral absorption, with a Tmax of 0.5 hours, t1/2 of 1.54 hours and a fraction absorbed of 44%, as well as a rapid clearance in male Sprague-Dawley rats[1].
LML134 (i.v.; 1 mg/kg) has t1/2 of 0.44 hours, CL of 28 mL/min/kg and the low plasma protein binding in male Sprague-Dawley rat (Fu =39.0%)[1].
IC 50
H3 receptor
References
[1] Troxler T, et al. The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders. ChemMedChem. 2019 Jul 3;14(13):1238-1247. DOI:10.1002/cmdc.201900176
LML-134 Preparation Products And Raw materials
Raw materials
Preparation Products
LML-134 Suppliers
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4757
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8000
- Advantage
- 62
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 9126
- Advantage
- 58
- Tel
- 0550-5196001 15000891977
- Fax
- 0550-5196001
- wj520wjxby@126.com
- Country
- China
- ProdList
- 1944
- Advantage
- 55
- Tel
- 0595-22008920; 18120708884
- 393612455@qq.com
- Country
- China
- ProdList
- 255
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6391
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30229
- Advantage
- 58