ChemicalBook > CAS DataBase List > 2,6-Piperidinedione, 3-[4-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-
2,6-Piperidinedione, 3-[4-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-
- Product Name
- 2,6-Piperidinedione, 3-[4-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-
- CAS No.
- 790652-68-5
- Chemical Name
- 2,6-Piperidinedione, 3-[4-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-
- Synonyms
- Lenalidomide-4-aminomethyl;3-[4-(Aminomethyl)-1-oxo-isoindolin-2-yl]piperidine-2,6-dione;3-[7-(aminomethyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione;3-[4-(Aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione;3-[4-(aminomethyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione;2,6-Piperidinedione, 3-[4-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-;3-[4-(Aminomethyl)-1-oxo-isoindolin-2-yl]piperidine-2,6-dione?, Lenalidomide-4-aminomethyl
- CBNumber
- CB85484342
- Molecular Formula
- C14H15N3O3
- Formula Weight
- 273.29
- MOL File
- 790652-68-5.mol
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2,6-Piperidinedione, 3-[4-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Property
- Boiling point:
- 594.9±50.0 °C(Predicted)
- Density
- 1.400±0.06 g/cm3(Predicted)
- pka
- 10.72±0.40(Predicted)
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N-Bromosuccinimide Price
Chemenu
- Product number
- CM327918
- Product name
- 3-[7-(aminomethyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
- Purity
- 95%+
- Packaging
- 50g
- Price
- $469
- Updated
- 2021/12/16
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2,6-Piperidinedione, 3-[4-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Chemical Properties,Usage,Production
Uses
Lenalidomide-4-aminomethyl is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl can be connected to the ligand for protein by a linker to form PROTAC[1].
IC 50
Cereblon
References
[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
2,6-Piperidinedione, 3-[4-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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