ChemicalBook > CAS DataBase List > 5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-
5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-
- Product Name
- 5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-
- CAS No.
- 2092917-63-8
- Chemical Name
- 5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-
- Synonyms
- (Rac)-VU 6008667;(Rac)VU 6008667,(Rac) VU 6008667;5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-
- CBNumber
- CB85514577
- Molecular Formula
- C24H17ClF2N2O2
- Formula Weight
- 438.85
- MOL File
- 2092917-63-8.mol
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5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro- Property
- Boiling point:
- 616.1±55.0 °C(Predicted)
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 125 mg/mL (284.84 mM); Water: < 0.1 mg/mL (insoluble)
- form
- Solid
- pka
- -2.76±0.40(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0100803
- Product name
- (Rac)-VU6008667
- Packaging
- 5mg
- Price
- $180
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0100803
- Product name
- (Rac)-VU6008667
- Packaging
- 10mg
- Price
- $330
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0100803
- Product name
- (Rac)-VU6008667
- Packaging
- 25mg
- Price
- $750
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0100803
- Product name
- (Rac)-VU6008667
- Packaging
- 50mg
- Price
- $1350
- Updated
- 2021/12/16
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5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro- Chemical Properties,Usage,Production
Uses
(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC50=1.8 μM, pIC50= 5.75), has high CNS penetration[1].
IC 50
mAChR5
References
[1] McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359. DOI:10.1016/j.bmcl.2017.02.020
5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro- Preparation Products And Raw materials
Raw materials
Preparation Products
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5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro- Suppliers
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