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ERK1/2 inhibitor 1

Product Name
ERK1/2 inhibitor 1
CAS No.
2095719-90-5
Chemical Name
ERK1/2 inhibitor 1
Synonyms
ERK1/2 INHIBITOR 1;ERK1/2 inhibitor 1, 10 mM in DMSO;ERK-1/2 inhibitor 1,ERK1/2 inhibitor 1;(R)-2-(6-(5-Chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-oxoisoindolin-2-yl)-N-((S)-2-hydroxy-1-(m-tolyl)ethyl)propanamide;2H-Isoindole-2-acetamide, 6-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-1,3-dihydro-N-[(1S)-2-hydroxy-1-(3-methylphenyl)ethyl]-α-methyl-1-oxo-, (αR)-
CBNumber
CB85540361
Molecular Formula
C29H32ClN5O4
Formula Weight
550.06
MOL File
2095719-90-5.mol
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ERK1/2 inhibitor 1 Property

Density 
1.344±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 250 mg/mL (454.50 mM; Need ultrasonic)
pka
13.73±0.46(Predicted)
form 
Solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0044721
Product name
ERK1/2inhibitor1
Purity
99.16%
Packaging
5mg
Price
$650
Updated
2021/12/16
ChemScene
Product number
CS-0044721
Product name
ERK1/2inhibitor1
Purity
99.16%
Packaging
10mg
Price
$980
Updated
2021/12/16
ChemScene
Product number
CS-0044721
Product name
ERK1/2inhibitor1
Purity
99.16%
Packaging
50mg
Price
$2550
Updated
2021/12/16
ChemScene
Product number
CS-0044721
Product name
ERK1/2inhibitor1
Purity
99.16%
Packaging
100mg
Price
$3550
Updated
2021/12/16
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ERK1/2 inhibitor 1 Chemical Properties,Usage,Production

Biological Activity

ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively[1]. ERK1/2 inhibitor 1 (Compound 27) shows excellent antiproliferative potency with IC50s of 4.9 and 7.5 nM in A375 and Colo205 cells, respectively[1].

References

[1]. Heightman TD, et al. Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J Med Chem. 2018 Jun 14;61(11):4978-4992.

ERK1/2 inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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ERK1/2 inhibitor 1 Suppliers

China 14 United States 3 Global 17
Shanghai Anyinuo Biomedical Technology Co., Ltd.
Tel
021-34625901
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420970979@qq.com
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China
ProdList
5795
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58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
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China
ProdList
9729
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
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sales@chemegen.com
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China
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11218
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cjbscvictory
Tel
13348960310 13348960310
Email
3003867561@qq.com
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China
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10524
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TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
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24644
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Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
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customer_service@efebio.com
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China
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11974
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Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
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021-59167510 18117107507
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vip@med-life.cn
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China
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4997
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Nanjing Shizhou Biology Technology Co.,Ltd
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025-85560043 15850508050
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025-85563444
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cindy.huang@synzest.com
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China
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Shanghai Zunlijia Life Technology Co., Ltd
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021-34045219 13062664914
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huji@zunlijia.com
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China
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10027
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Nantong Hanfang Biotechnology Co. , Ltd.
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18616537568
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hanfangpharma@126.com
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China
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29981
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RD International Technology Co., Limited
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18024082417
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market@ubiochem.com
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China
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400-821-026
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sangon@qq.com
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China
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47239
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Absin Bioscience Inc.
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chenjw@absin.cn
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CHINA
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Proteintech China
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Proteintech-CN@ptglab.com
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CHINA
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2095719-90-5, ERK1/2 inhibitor 1Related Search:


  • ERK1/2 INHIBITOR 1
  • 2H-Isoindole-2-acetamide, 6-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-1,3-dihydro-N-[(1S)-2-hydroxy-1-(3-methylphenyl)ethyl]-α-methyl-1-oxo-, (αR)-
  • ERK-1/2 inhibitor 1,ERK1/2 inhibitor 1
  • (R)-2-(6-(5-Chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-oxoisoindolin-2-yl)-N-((S)-2-hydroxy-1-(m-tolyl)ethyl)propanamide
  • ERK1/2 inhibitor 1, 10 mM in DMSO
  • 2095719-90-5
  • C29H32ClN5O4