ChemicalBook > CAS DataBase List > FLT3-IN-4
FLT3-IN-4
- Product Name
- FLT3-IN-4
- CAS No.
- 2304799-09-3
- Chemical Name
- FLT3-IN-4
- Synonyms
- FLT3-IN-4;FLT3-IN-4, 10 mM in DMSO;1-{4-[4-amino-7-(prop-2-en-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl}-3-(5-tert-butyl-1,2-oxazol-3-yl)urea;Urea, N-[4-[4-amino-7-(2-propen-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]-N'-[5-(1,1-dimethylethyl)-3-isoxazolyl]-
- CBNumber
- CB85540578
- Molecular Formula
- C23H25N7O2
- Formula Weight
- 431.49
- MOL File
- 2304799-09-3.mol
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FLT3-IN-4 Property
- Boiling point:
- 589.1±50.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 12.68±0.70(Predicted)
- form
- Solid
- color
- White to off-white
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FLT3-IN-4 Chemical Properties,Usage,Production
Description
FLT3-IN-4 is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor for treating acute myelogenous leukemia[1].
FLT3-IN-4 (Compound 9u) shows potent inhibitory activities against MV4-11 and Molm-13 cells with IC50 values are 0.089±0.001 nM and 0.022±0.003 nM, respectively[1].
References
[1]. Yuan X, et al. Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia. J Med Chem. 2019 Apr 25;62(8):4158-4173.
FLT3-IN-4 Preparation Products And Raw materials
Raw materials
Preparation Products
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FLT3-IN-4 Suppliers
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