EGFR-IN-5

Product Name: EGFR-IN-5
CAS No.: 2225887-26-1
Chemical Name: EGFR-IN-5
Synonyms: EGFR-IN-5;EGFR-IN-5, 10 mM in DMSO;inhibit,Epidermal growth factor receptor,HER1,ErbB-1,Inhibitor,EGFR IN 5,EGFRIN5,EGFR;4-Piperidinemethanol, 1-[6-[[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]amino]-2-[(4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-4-yl]-;(1-(6-((5-(4-(Dimethylamino)piperidin-1-yl)pyridin-2-yl)amino)-2-((4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-4-yl)piperidin-4-yl)methanol
CBNumber: CB85540619
Molecular Formula: C31H38FN9O
Formula Weight: 571.69
MOL File: 2225887-26-1.mol

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EGFR-IN-5 Property

Boiling point:: 788.2±70.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (218.65 mM; Need ultrasonic)
pka: 14.94±0.10(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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EGFR-IN-5 Chemical Properties,Usage,Production

Uses

EGFR-IN-5 is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.

IC 50

EGFR: 10.4 nM (IC₅₀); EGFR^L858R: 1.1 nM (IC₅₀); EGFR^L858R/T790M: 34 nM (IC₅₀); EGFR^{L858R/T790M/C797S}: 7.2 nM (IC₅₀)

References

[1] Zhang H, et al. Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs. Eur J Med Chem. 2018 Mar 25;148:221-237. DOI:10.1016/j.ejmech.2018.02.051

EGFR-IN-5 Preparation Products And Raw materials

Raw materials

Preparation Products

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EGFR-IN-5 Suppliers

China 27 United States 4 Global 31

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
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Email: info@efebio.com
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Jingmo (Xiamen) Biotechnology Co., Ltd

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cjbscvictory

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Beijing Jin Ming Biotechnology Co., Ltd.

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Bide Pharmatech Ltd.

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InvivoChem

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2225887-26-1, EGFR-IN-5Related Search:

EGFR-IN-5

(1-(6-((5-(4-(Dimethylamino)piperidin-1-yl)pyridin-2-yl)amino)-2-((4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-4-yl)piperidin-4-yl)methanol

inhibit,Epidermal growth factor receptor,HER1,ErbB-1,Inhibitor,EGFR IN 5,EGFRIN5,EGFR

4-Piperidinemethanol, 1-[6-[[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]amino]-2-[(4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-4-yl]-

EGFR-IN-5, 10 mM in DMSO

2225887-26-1

C31H38FN9O