ChemicalBook > CAS DataBase List > Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-

Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-

Product Name: Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-
CAS No.: 1606974-33-7
Chemical Name: Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-
Synonyms: BPN14770;Zatolmilast;Zatolmilast (BPN14770);Zatolmilast, 10 mM in DMSO;Zatolmilast (BPN14770) ，S6844;Zatolmilast,Phosphodiesterase (PDE),BPN-14770,Inhibitor,BPN 14770,inhibit;2-(4-{[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl}phenyl)acetic acid;Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-
CBNumber: CB85552252
Molecular Formula: C21H15ClF3NO2
Formula Weight: 405.8
MOL File: 1606974-33-7.mol

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Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Property

Boiling point:: 514.4±50.0 °C(Predicted)
Density: 1.351±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 260 mg/mL (640.71 mM)
pka: 4.27±0.10(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Axon Medchem

Product number: Axon3148
Product name: BPN14770
Purity: 99%
Packaging: 5mg
Price: $132
Updated: 2021/12/16

Axon Medchem

Product number: Axon3148
Product name: BPN14770
Purity: 99%
Packaging: 2x5mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-0066529
Product name: BPN14770
Purity: 99.39%
Packaging: 5mg
Price: $280
Updated: 2021/12/16

ChemScene

Product number: CS-0066529
Product name: BPN14770
Purity: 99.39%
Packaging: 10mg
Price: $520
Updated: 2021/12/16

ChemScene

Product number: CS-0066529
Product name: BPN14770
Purity: 99.39%
Packaging: 25mg
Price: $990
Updated: 2021/12/16

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Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Chemical Properties,Usage,Production

Uses

Zatolmilast is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor for the treatment of fragile X syndrome and other brain disorders.

in vivo

Zatolmilast increases brain cAMP, increases phosphorylation of CREB and increases production of brain-derived neurotrophic factor (BDNF) in hippocampus^[1].
? Zatolmilast (0.1-30 mg/kg; p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition (NOR) at doses above 0.3 mg/kg^[2].

Animal Model:	C57Bl6 mice^[2]
Dosage:	0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration:	p.o.; 24?hours
Result:	Significantly improved novel object discrimination at doses above 0.3 mg/kg.

IC 50

PDE4D3: 7.4 nM (IC₅₀); PDE4D7: 7.8 nM (IC₅₀)

Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: BPN14770 1606974-33-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2025-08-31

1606974-33-7, Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-Related Search:

Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-

BPN14770

Zatolmilast

Zatolmilast,Phosphodiesterase (PDE),BPN-14770,Inhibitor,BPN 14770,inhibit

2-(4-{[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl}phenyl)acetic acid

Zatolmilast, 10 mM in DMSO

Zatolmilast (BPN14770)

Zatolmilast (BPN14770) ，S6844

1606974-33-7

C21H15ClF3NO2