ChemicalBook > CAS DataBase List > Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]-
Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]-
- Product Name
- Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]-
- CAS No.
- 2349368-16-5
- Chemical Name
- Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]-
- Synonyms
- XY101;XY101,XY-101;XY101, 10 mM in DMSO;Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]-
- CBNumber
- CB85569067
- Molecular Formula
- C25H20F7NO4S
- Formula Weight
- 563.48
- MOL File
- 2349368-16-5.mol
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Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]- Property
- Boiling point:
- 682.4±55.0 °C(Predicted)
- Density
- 1.439±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 250 mg/mL (443.67 mM)
- pka
- 8.87±0.19(Predicted)
- form
- Solid
- color
- Off-white to light yellow
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0096107
- Product name
- XY101
- Purity
- 98.88%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0096107
- Product name
- XY101
- Purity
- 98.88%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0096107
- Product name
- XY101
- Purity
- 98.88%
- Packaging
- 50mg
- Price
- $1800
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0096107
- Product name
- XY101
- Purity
- 98.88%
- Packaging
- 100mg
- Price
- $3000
- Updated
- 2021/12/16
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Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]- Chemical Properties,Usage,Production
Description
XY101 is a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer with IC50 = 30nM. XY101 potently inhibited cell growth, colony formation, and the expression of AR, AR-V7, and PSA. XY101 also exhibited good metabolic stability and a pharmacokinetic profile with oral bioavailability of 59% and a half-life of 7.3 h. Notably, XY101 demonstrated promising therapeutic effects with significant tumor growth inhibition in a prostate cancer xenograft model inmice.
Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]- Suppliers
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