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WJ460

Product Name
WJ460
CAS No.
1415251-36-3
Chemical Name
WJ460
Synonyms
WJ460;WJ-460.WJ460;WJ-460.WJ460;WJ 460;WJ460, 10 mM in DMSO;Myoferlin inhibitor WJ460);3-(3-(2-Methoxyphenyl)-4-oxothiazolidin-2-yl)-N-(4-phenylbutyl)benzamide;Benzamide, 3-[3-(2-methoxyphenyl)-4-oxo-2-thiazolidinyl]-N-(4-phenylbutyl)-;3-[3-(2-methoxyphenyl)-4-oxo-1,3-thiazolidin-2-yl]-N-(4-phenylbutyl)benzamide;WJ460 3-(3-(2-Methoxyphenyl)-4-oxothiazolidin-2-yl)-N-(4- phenylbutyl)benzamide
CBNumber
CB85574272
Molecular Formula
C27H28N2O3S
Formula Weight
460.59
MOL File
1415251-36-3.mol
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WJ460 Property

Boiling point:
741.7±60.0 °C(Predicted)
Density 
1.216±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 250 mg/mL (542.78 mM)
pka
14.60±0.46(Predicted)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

DC Chemicals
Product number
DC11286
Product name
WJ460
Purity
>98%
Packaging
100mg
Price
$950
Updated
2021/12/16
DC Chemicals
Product number
DC11286
Product name
WJ460
Purity
>98%
Packaging
250mg
Price
$1600
Updated
2021/12/16
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WJ460 Chemical Properties,Usage,Production

Uses

WJ460 is a potent inhibitor of myoferlin (MYOF) that interacts directly with MYOF. WJ460 inhibits the migration and growth, induces cell cycle arrest, mitochondrial autophagy, lipid peroxidation and ferroptosis in tumor cells. WJ460 has anti-tumor activity[1][2].

in vivo

WJ460 (5-10mg/kg; intraperitoneal injection; single dose) has antitumor activity in nude mouse breast cancer metastasis model[2].

Animal Model:MDA-MB-231-Luciferase cells treated athymic nude mice[2]
Dosage:5 and 10mg/kg
Administration:Intraperitoneal injection (i.p.); single dose
Result:Significantly inhibited breast cancer pulmonary metastasis in a concentration-dependent manner.
Inhibited the proliferation of MDA-MB-231 cells.
Increased mouse overall survival.

References

[1] Rademaker G, et al. Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells. Redox Biol. 2022 Jul;53:102324. DOI:10.1016/j.redox.2022.102324
[2] Zhang T, et al. A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer. Nat Commun. 2018 Sep 13;9(1):3726. DOI:10.1038/s41467-018-06179-0

WJ460 Preparation Products And Raw materials

Raw materials

Preparation Products

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WJ460 Suppliers

China 30 United States 2 Global 32
Shanghai Raise Chemical Technology Co.,Ltd
Tel
15026594951
Fax
0556-5030632
Email
rs@raise-chem.com
Country
China
ProdList
4547
Advantage
55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4797
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32470
Advantage
58
Shanghai Dongyang Biotechnology Co., Ltd.
Tel
0512-0512-13601744364 13601744364
Email
chemsharker@126.com
Country
China
ProdList
1060
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4920
Advantage
58
cjbscvictory
Tel
13348960310
Email
3003867561@qq.com
Country
China
ProdList
10503
Advantage
58

1415251-36-3, WJ460Related Search:


  • WJ460
  • WJ-460.WJ460
  • WJ-460.WJ460;WJ 460
  • WJ460 3-(3-(2-Methoxyphenyl)-4-oxothiazolidin-2-yl)-N-(4- phenylbutyl)benzamide
  • 3-(3-(2-Methoxyphenyl)-4-oxothiazolidin-2-yl)-N-(4-phenylbutyl)benzamide
  • Benzamide, 3-[3-(2-methoxyphenyl)-4-oxo-2-thiazolidinyl]-N-(4-phenylbutyl)-
  • 3-[3-(2-methoxyphenyl)-4-oxo-1,3-thiazolidin-2-yl]-N-(4-phenylbutyl)benzamide
  • WJ460, 10 mM in DMSO
  • Myoferlin inhibitor WJ460)
  • 1415251-36-3