ChemicalBook > CAS DataBase List > Mc-Val-Cit-PAB-Cl

Mc-Val-Cit-PAB-Cl

Product Name: Mc-Val-Cit-PAB-Cl
CAS No.: 1639351-92-0
Chemical Name: Mc-Val-Cit-PAB-Cl
Synonyms: Mc-Val-Cit-PAB-Cl;Mc Val Cit PAB Cl,Antibody-drug conjugates linkers,McValCitPABCl,ADC Linkers,inhibit,Inhibitor;L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(chloromethyl)phenyl]-;N-[(S)-1-[[(S)-1-[[4-(Chloromethyl)phenyl]amino]-1-oxo-5-ureido-2-pentyl]amino]-3-methyl-1-oxo-2-butyl]-6-(2,5-dioxo-2,5-dihydro-1-pyrrolyl)hexanamide;N-[(1S)-1-{[(1S)-4-(carbamoylamino)-1-{[4-(chloromethyl)phenyl]carbamoyl}butyl]carbamoyl}-2-methylpropyl]-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide;N-((S)-1-(((S)-1-((4-(Chloromethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide
CBNumber: CB85821132
Molecular Formula: C28H39ClN6O6
Formula Weight: 591.1
MOL File: 1639351-92-0.mol

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Mc-Val-Cit-PAB-Cl Property

Boiling point:: 915.4±65.0 °C(Predicted)
Density: 1.278±0.06 g/cm3(Predicted)
storage temp.: -20°C, stored under nitrogen
form: Solid
pka: 13.30±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0043347
Product name: Mc-Val-Cit-PAB-Cl
Packaging: 100mg
Price: $2000
Updated: 2021/12/16

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Mc-Val-Cit-PAB-Cl Chemical Properties,Usage,Production

Uses

Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).

IC 50

Protease Cleavable Linker; Cleavable Linker

References

[1] Staben LR, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8(10):1037-1041. DOI:10.1021/acsmedchemlett.7b00243

Mc-Val-Cit-PAB-Cl Preparation Products And Raw materials

Raw materials

Preparation Products

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1639351-92-0, Mc-Val-Cit-PAB-ClRelated Search:

Mc-Val-Cit-PAB-Cl

L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(chloromethyl)phenyl]-

Mc Val Cit PAB Cl,Antibody-drug conjugates linkers,McValCitPABCl,ADC Linkers,inhibit,Inhibitor

N-[(S)-1-[[(S)-1-[[4-(Chloromethyl)phenyl]amino]-1-oxo-5-ureido-2-pentyl]amino]-3-methyl-1-oxo-2-butyl]-6-(2,5-dioxo-2,5-dihydro-1-pyrrolyl)hexanamide

N-[(1S)-1-{[(1S)-4-(carbamoylamino)-1-{[4-(chloromethyl)phenyl]carbamoyl}butyl]carbamoyl}-2-methylpropyl]-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide

N-((S)-1-(((S)-1-((4-(Chloromethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide

1639351-92-0

C28H39ClN6O6