N- [1- [(1R, 3S, 4S, 6R, 7S) - 4- [[Bis(4- Methoxyphenyl) - Phenylmethoxy] Methyl] - 7- [2- Cyanoeth

Product Name: N- [1- [(1R, 3S, 4S, 6R, 7S) - 4- [[Bis(4- Methoxyphenyl) - Phenylmethoxy] Methyl] - 7- [2- Cyanoeth
CAS No.: 1197033-17-2
Chemical Name: N- [1- [(1R, 3S, 4S, 6R, 7S) - 4- [[Bis(4- Methoxyphenyl) - Phenylmethoxy] Methyl] - 7- [2- Cyanoeth
Synonyms: S-cEt-C phosphoramidite;CET-5-Me-C(Bz) Phosphoramidite;N6-Bz-C-(S)-cEt-Phosphoramidite;S-cEt-5-Me-C(Bz) phosphoramidite;S-cEt-5Me-C(Bz)-CE-Phosphoramidite;5'-O-DMTr-cEt-BNA-N-Bz-Me-Cytidine-CEP;5’-O-DMTr-cEt 5MeC(Bz) Phosphoramidite;5'-ODMT cEt N-Bz 5-Me C Phosphoramidite;5'-ODMTcEtN-Bzm5CPhosphoramiditeAmidite;(S)-cEt-5-Me-C(Bz)-3'-CE-phosphoramidite
CBNumber: CB85839757
Molecular Formula: C49H56N5O9P
Formula Weight: 889.97
MOL File: 1197033-17-2.mol

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N- [1- [(1R, 3S, 4S, 6R, 7S) - 4- [[Bis(4- Methoxyphenyl) - Phenylmethoxy] Methyl] - 7- [2- Cyanoeth Property

pka: 8.60±0.40(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N- [1- [(1R, 3S, 4S, 6R, 7S) - 4- [[Bis(4- Methoxyphenyl) - Phenylmethoxy] Methyl] - 7- [2- Cyanoeth Chemical Properties,Usage,Production

Uses

5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite blongs to modified antisense oligonucleotide. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite allows the formation of a specific conformation of the furanose ring of the oligonucleotide through the introduction of a cEt modification, enhancing the ability to hybridize to complementary RNA. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is mainly used in the research of regulation of gene expression related to metabolic diseases, cardiovascular diseases, cancers and the development of antisense compounds[1][2].

References

[1] Yu J, et al. Synthesis and antisense properties of 2'-O-(2S-methoxypropyl)-RNA-modified gapmer antisense oligonucleotides. ChemMedChem. 2014 Sep;9(9):2040-4. DOI:10.1002/cmdc.201402099
[2] Seth P P, et al. Synthesis and biophysical evaluation of 2′, 4′-constrained 2′ O-methoxyethyl and 2′, 4′-constrained 2′ O-ethyl nucleic acid analogues. The Journal of organic chemistry, 2010, 75(5): 1569-1581.

N- [1- [(1R, 3S, 4S, 6R, 7S) - 4- [[Bis(4- Methoxyphenyl) - Phenylmethoxy] Methyl] - 7- [2- Cyanoeth Preparation Products And Raw materials

Raw materials

Preparation Products

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N- [1- [(1R, 3S, 4S, 6R, 7S) - 4- [[Bis(4- Methoxyphenyl) - Phenylmethoxy] Methyl] - 7- [2- Cyanoeth Suppliers

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1197033-17-2, N- [1- [(1R, 3S, 4S, 6R, 7S) - 4- [[Bis(4- Methoxyphenyl) - Phenylmethoxy] Methyl] - 7- [2- CyanoethRelated Search:

N- [1- [(1R, 3S, 4S, 6R, 7S) - 4- [[Bis(4- Methoxyphenyl) - Phenylmethoxy] Methyl] - 7- [2- Cyanoeth

Benzamide, N-[1-[2,5-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-1,2-dihydro-5-methyl-2-oxo-4-pyrimidinyl]-

5'-O-DMTr-cEt-BNA-N-Bz-Me-Cytidine-CEP

5'-ODMT cEt N-Bz 5-Me C Phosphoramidite

S-cEt-C phosphoramidite

CET-5-Me-C(Bz) Phosphoramidite

5'-ODMTcEtN-Bzm5CPhosphoramiditeAmidite

S-cEt-5Me-C(Bz)-CE-Phosphoramidite

N6-Bz-C-(S)-cEt-Phosphoramidite

S-cEt-5-Me-C(Bz) phosphoramidite

(1S,3R,4R,6S,7S)-7-[2-cyanoethoxy(diisopropylamino)phosphinoxy]-1-(4,4'-dimethoxytrityloxymethyl)-6-methyl-3-(5-methyl-4-N-benzoylcytosin-1-yl)-2,5-dioxa-bicyclo[2.2.1]heptane

N-[1-[(1R,3S,4S,6R,7S)-4-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methyl-2,5-dioxabicyclo[2.2.1]heptan-6-yl]-5-methyl-2-oxopyrimidin-4-yl]benzamide

(S)-cEt-5-Me-C(Bz)-3'-CE-phosphoramidite

DMT-CET-5-Me-rC (Bz) phosphoramidite monomer

5’-O-DMTr-cEt 5MeC(Bz) Phosphoramidite

1H,5H,11H,15H-Quinolizino[1′,9′:5,6,7]xantheno[2,3,4-ij]quinolizin-18-ium, 9-[5-[10-[bis(1-methylethyl)amino]-13-cyano-1-oxido-1-[4-[(2,2,2-trifluoroacetyl)amino]butoxy]-2,9,11-trioxa-1,10-diphosphatridec-1-yl]-2-[(diethylamino)carbonyl]phenyl]-2,3,6,7,12,13,16,17-octahydro-, hexafluorophosphate(1-) (1:1) (ACI)

1197033-17-2

1190733-17-2

C49H56N5O9P

Amidite