TBOPP

Product Name: TBOPP
CAS No.: 1996629-79-8
Chemical Name: TBOPP
Synonyms: TBOPP;TBOPP, 10 mM in DMSO;Inhibitor,TBOPP,inhibit;1-[2-oxo-2-[4-[3-(trifluoromethyl)phenyl]phenyl]ethyl]-5-pyrrolidin-1-ylsulfonyl-pyridin-2-one;1-(2-Oxo-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)ethyl)-5-(pyrrolidin-1-ylsulfonyl)pyridin-2(1H)-one;2(1H)-Pyridinone, 1-[2-oxo-2-[3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]ethyl]-5-(1-pyrrolidinylsulfonyl)-
CBNumber: CB85848874
Molecular Formula: C24H21F3N2O4S
Formula Weight: 490.49
MOL File: 1996629-79-8.mol

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TBOPP Property

Boiling point:: 645.4±65.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 125 mg/mL (254.85 mM)
pka: -2.46±0.70(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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TBOPP Chemical Properties,Usage,Production

Uses

1-(2-Oxo-2-(3''-(trifluoromethyl)-[1,1''-biphenyl]-4-yl)ethyl)-5-(pyrrolidin-1-ylsulfonyl)pyridin-2(1H)-one is a selective inhibitor of DOCK1 as a therapeutic approach to target cancer cell survival and invasion.

in vivo

TBOPP (0.67 mg per mouse; administrated on days 0, 1, 3, and 5; for 2 weeks; C57BL/6 mice) treatment effectively suppresses metastasis of cancer cells in vivo and the number of lymphocytes in the spleen is not changed, the body weight is also unchanged between TBOPP-treated and non-treated mice^[1].

Animal Model:	C57BL/6 mice (6- to 8-week-old) with ex-3LL cells^[1]
Dosage:	0.67 mg per mouse
Administration:	Administrated on days 0, 1, 3, and 5; for 2 weeks
Result:	The lung metastasis was significantly suppressed.

TBOPP Preparation Products And Raw materials

Raw materials

Preparation Products

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TBOPP Suppliers

China 24 United States 3 Global 27

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
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Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 9675
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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
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Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
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Taizhou Crene Biotechnology Co. Ltd.

Tel: +86-0576-88813233 +86-13396860566
Email: sales@pharm-intermediates.com
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TargetMol Chemicals Inc.

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Email: marketing@targetmol.com
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
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Email: sales@chemegen.com
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Shandong Jirun Biomedical Technology Co., Ltd.

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Shanghai hongqu biomedical technology co. LTD

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Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
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1996629-79-8, TBOPPRelated Search:

TBOPP

2(1H)-Pyridinone, 1-[2-oxo-2-[3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]ethyl]-5-(1-pyrrolidinylsulfonyl)-

1-(2-Oxo-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)ethyl)-5-(pyrrolidin-1-ylsulfonyl)pyridin-2(1H)-one

Inhibitor,TBOPP,inhibit

1-[2-oxo-2-[4-[3-(trifluoromethyl)phenyl]phenyl]ethyl]-5-pyrrolidin-1-ylsulfonyl-pyridin-2-one

TBOPP, 10 mM in DMSO

1996629-79-8

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