ChemicalBook > CAS DataBase List > PS 210

PS 210

Product Name
PS 210
CAS No.
1221962-86-2
Chemical Name
PS 210
Synonyms
PS 210;PS210, 10 mM in DMSO;2-[3-oxo-1-phenylpropyl-3-(4-trifluoromethylphenyl)]malonic acid;2-[3-Oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]malonic Acid;2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-propanedioic acid;Propanedioic acid, 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-;pocket,PS 210,Arg131,Thr148,S6K,PS423,PIF-binding,PDK-1,PIFtide,PS-210,PS210,Inhibitor,a-B,Lys76,helix,inhibit
CBNumber
CB85867297
Molecular Formula
C19H15F3O5
Formula Weight
380.31
MOL File
1221962-86-2.mol
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PS 210 Property

Boiling point:
577.9±50.0 °C(Predicted)
Density 
1.400±0.06 g/cm3(Predicted)
solubility 
DMSO:100.0(Max Conc. mg/mL);262.94(Max Conc. mM)
form 
A crystalline solid
pka
2.93±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals
Product number
DC21536
Product name
PS210
Purity
>98%
Packaging
100mg
Price
$850
Updated
2021/12/16
DC Chemicals
Product number
DC21536
Product name
PS210
Purity
>98%
Packaging
250mg
Price
$1450
Updated
2021/12/16
DC Chemicals
Product number
DC21536
Product name
PS210
Purity
>98%
Packaging
1g
Price
$2900
Updated
2021/12/16
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PS 210 Chemical Properties,Usage,Production

Uses

PS210 is a potent and selective PDK1 activator with a Kd of 3 μM and targets the PIF-binding pocket of PDK1. PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt or GSK3. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K[1][2].

References

[1] Busschots K, et al. Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site. Chem Biol. 2012 Sep 21;19(9):1152-63. DOI:10.1016/j.chembiol.2012.07.017
[2] Rettenmaier TJ, et al. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5. DOI:10.1073/pnas.1415365112

PS 210 Preparation Products And Raw materials

Raw materials

Preparation Products

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1221962-86-2, PS 210Related Search:


  • PS 210
  • 2-[3-Oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]malonic Acid
  • Propanedioic acid, 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-
  • 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-propanedioic acid
  • pocket,PS 210,Arg131,Thr148,S6K,PS423,PIF-binding,PDK-1,PIFtide,PS-210,PS210,Inhibitor,a-B,Lys76,helix,inhibit
  • PS210, 10 mM in DMSO
  • 2-[3-oxo-1-phenylpropyl-3-(4-trifluoromethylphenyl)]malonic acid
  • 1221962-86-2