ChemicalBook > CAS DataBase List > PS 210

PS 210

Product Name: PS 210
CAS No.: 1221962-86-2
Chemical Name: PS 210
Synonyms: PS 210;PS210 ，S3462;PS210, 10 mM in DMSO;2-[3-oxo-1-phenylpropyl-3-(4-trifluoromethylphenyl)]malonic acid;2-[3-Oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]malonic Acid;2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-propanedioic acid;Propanedioic acid, 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-;pocket,PS 210,Arg131,Thr148,S6K,PS423,PIF-binding,PDK-1,PIFtide,PS-210,PS210,Inhibitor,a-B,Lys76,helix,inhibit
CBNumber: CB85867297
Molecular Formula: C19H15F3O5
Formula Weight: 380.31
MOL File: 1221962-86-2.mol

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PS 210 Property

Boiling point:: 577.9±50.0 °C(Predicted)
Density: 1.400±0.06 g/cm3(Predicted)
storage temp.: Storage temp. -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);262.94(Max Conc. mM)
form: A crystalline solid
pka: 2.93±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC21536
Product name: PS210
Purity: >98%
Packaging: 100mg
Price: $850
Updated: 2021/12/16

DC Chemicals

Product number: DC21536
Product name: PS210
Purity: >98%
Packaging: 250mg
Price: $1450
Updated: 2021/12/16

DC Chemicals

Product number: DC21536
Product name: PS210
Purity: >98%
Packaging: 1g
Price: $2900
Updated: 2021/12/16

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PS 210 Chemical Properties,Usage,Production

Uses

PS210 is a potent and selective PDK1 activator with a Kd of 3 μM and targets the PIF-binding pocket of PDK1. PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt or GSK3. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K[1][2].

References

[1] Busschots K, et al. Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site. Chem Biol. 2012 Sep 21;19(9):1152-63. DOI:10.1016/j.chembiol.2012.07.017
[2] Rettenmaier TJ, et al. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5. DOI:10.1073/pnas.1415365112

PS 210 Preparation Products And Raw materials

Raw materials

Preparation Products

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1221962-86-2, PS 210Related Search:

PS 210

2-[3-Oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]malonic Acid

Propanedioic acid, 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-

2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-propanedioic acid

pocket,PS 210,Arg131,Thr148,S6K,PS423,PIF-binding,PDK-1,PIFtide,PS-210,PS210,Inhibitor,a-B,Lys76,helix,inhibit

PS210, 10 mM in DMSO

2-[3-oxo-1-phenylpropyl-3-(4-trifluoromethylphenyl)]malonic acid

PS210 ，S3462

1221962-86-2