Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]-

Product Name: Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]-
CAS No.: 1893397-65-3
Chemical Name: Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]-
Synonyms: TBK1/IKKepsilon-IN-5;TBK1/IKKε inhibitor 5;TBK1/IKKε-IN-1(compound 1);TBK1/IKKε-IN-5, 10 mM in DMSO;I kappa B kinase,Inhibitor,inhibit,IKK,IκB kinase,TBK1/IKKε IN 5,TBK-1/IKKε-IN-5,TBK1/IKKεIN5;5-(4-((4-(4-(Oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile;Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]-
CBNumber: CB85954126
Molecular Formula: C28H31N7O3
Formula Weight: 513.59
MOL File: 1893397-65-3.mol

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Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]- Property

storage temp.: Store at -20°C
solubility: DMSO: 7.81 mg/mL (15.21 mM)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0097133
Product name: TBK1/IKKε-IN-5
Purity: 99.80%
Packaging: 1mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0097133
Product name: TBK1/IKKε-IN-5
Purity: 99.80%
Packaging: 5mg
Price: $980
Updated: 2021/12/16

ChemScene

Product number: CS-0097133
Product name: TBK1/IKKε-IN-5
Purity: 99.80%
Packaging: 10mg
Price: $1500
Updated: 2021/12/16

Ambeed

Product number: A1177218
Product name: 5-(4-((4-(4-(Oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile
Purity: 98%
Packaging: 1g
Price: $1410
Updated: 2021/12/16

Ambeed

Product number: A1177218
Product name: 5-(4-((4-(4-(Oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile
Purity: 98%
Packaging: 1mg
Price: $64
Updated: 2021/12/16

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Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]- Chemical Properties,Usage,Production

Uses

TBK1/IKKε-IN-1 is a dual inhibitor of TANK-binding kinase 1 (TBK1) and IκB kinase-ε (IKKε/IKK-i).

in vivo

TBK1/IKKε-IN-5 (40 mg/kg; p.o.; single daily for 26 days) shows good antitumor activity and prolongs survival, as well as induces immunologic memory of CT26 cells in mice when combines with anti-PD-L1^[1].

Animal Model:	Female Balb/c mice (11 to 12-week-old; bearing CT26 tumors)^[1].
Dosage:	40 mg/kg
Administration:	Oral gavage; single daily for 26 days (combine with anti-PD-L1).
Result:	Exhibited greater tumor control and longer survival when combined with anti-PD-L1 than used alone of both agents Induced immunologic memory of CT26 cells in mice when combined with anti-PD-L1.

Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]- Suppliers

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1893397-65-3, Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]-Related Search:

Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]-

TBK1/IKKε inhibitor 5

I kappa B kinase,Inhibitor,inhibit,IKK,IκB kinase,TBK1/IKKε IN 5,TBK-1/IKKε-IN-5,TBK1/IKKεIN5

5-(4-((4-(4-(Oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile

TBK1/IKKepsilon-IN-5

TBK1/IKKε-IN-1(compound 1)

TBK1/IKKε-IN-5, 10 mM in DMSO

1893397-65-3

C28H31N7O3