VH 032-linker 4

Product Name: VH 032-linker 4
CAS No.: 2140807-42-5
Chemical Name: VH 032-linker 4
Synonyms: BP-24504;VH 032-linker 4;VH 032 amide-PEG3-acid;(S,R. S)-AHPC-PEG3-acid;(S,R,S)-AHPC-PEG3-propionic acid;L-Prolinamide, N-[3-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(S)-15-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-16,16-dimethyl-13-oxo-4,7,10-trioxa-14-azaheptadecan-1-oic acid;3-{2-[2-(2-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}ethoxy)ethoxy]ethoxy}propanoic acid
CBNumber: CB85985162
Molecular Formula: C32H46N4O9S
Formula Weight: 662.79
MOL File: 2140807-42-5.mol

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VH 032-linker 4 Property

Boiling point:: 930.2±65.0 °C(Predicted)
Density: 1.264±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO, DMF, MeOH
pka: 4.28±0.10(Predicted)
form: Liquid
color: Colorless to light yellow

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Safety

HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 930512
Product name: VH 032 amide-PEG3-acid
Purity: ≥95.0%
Packaging: 50MG
Price: $234.6
Updated: 2025/07/31

Tocris

Product number: 6679
Product name: VH032amide-PEG3-acid
Purity: ≥95%(HPLC)
Packaging: 25
Price: $208
Updated: 2021/12/16

BroadPharm

Product number: BP-24504
Product name: (S,R.S)-AHPC-PEG3-acid
Purity: 98%
Packaging: 100mg
Price: $540
Updated: 2021/12/16

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VH 032-linker 4 Chemical Properties,Usage,Production

Description

(S, R, S)-AHPC-PEG3-acid is a PROTAC linker that incorporate an E3 ligase ligand with a PEG3 linker to empower PROTAC drug research & discovery.

Uses

(S,R,S)-AHPC-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology[1].

IC 50

VHL

storage

Store at -20°C

References

[1] Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513. DOI:10.1021/acs.jmedchem.6b01912

VH 032-linker 4 Preparation Products And Raw materials

Raw materials

Preparation Products

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VH 032-linker 4 Suppliers

China 23 United States 3 Global 26

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
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Shanghai YuanYe Biotechnology Co., Ltd.

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SuZhou Medinoah Co.,LTD.

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Shanghai Hongye Biotechnology Co. Ltd

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Jilin Province Woda Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Zhengzhou Akem Chemical Co., Ltd

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Bide Pharmatech Ltd.

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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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TargetMol Chemicals Inc.

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2140807-42-5, VH 032-linker 4Related Search:

VH 032-linker 4

(S,R. S)-AHPC-PEG3-acid

L-Prolinamide, N-[3-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

VH 032 amide-PEG3-acid

(S,R,S)-AHPC-PEG3-propionic acid

(S)-15-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-16,16-dimethyl-13-oxo-4,7,10-trioxa-14-azaheptadecan-1-oic acid

3-{2-[2-(2-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}ethoxy)ethoxy]ethoxy}propanoic acid

BP-24504

2140807-42-5

C32H46N4O9S