DPTIP

Product Name: DPTIP
CAS No.: 351353-48-5
Chemical Name: DPTIP
Synonyms: DPTIP;DPTIP, 10 mM in DMSO;Phenol, 2,6-dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]-;2,6-Dimethoxy-4-(4-phenyl-5-(thiophen-2-yl)-1H-imidazol-2-yl)phenol;2,6-dimethoxy-4-[5-phenyl-4-(thiophen-2-yl)-1H-im idazol-2-yl]phenol;extracellular,Inhibitor,exosome,DPTIP,Phospholipase,vesicles,inhibit,N-SMase
CBNumber: CB85985177
Molecular Formula: C21H18N2O3S
Formula Weight: 378.44
MOL File: 351353-48-5.mol

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DPTIP Property

Boiling point:: 608.3±55.0 °C(Predicted)
Density: 1.292±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 9.27±0.25(Predicted)
form: Solid
color: Off-white to gray

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 6903
Product name: DPTIP
Purity: ≥98%(HPLC)
Packaging: 10
Price: $185
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BD171497
Product name: DPTIP
Packaging: 5mg
Price: $195
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BD171497
Product name: DPTIP
Packaging: 10mg
Price: $250
Updated: 2021/12/16

AK Scientific

Product number: 5386CE
Product name: 2,6-Dimethoxy-4-(5-phenyl-4-thiophen-2-yl-1H-imidazol-2-yl)-phenol
Packaging: 10mg
Price: $387
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BD171497
Product name: DPTIP
Packaging: 25mg
Price: $575
Updated: 2021/12/16

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DPTIP Chemical Properties,Usage,Production

Uses

DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM[1][2].

in vivo

DPTIP potently (10?mg/kg IP) inhibits IL-1β-induced astrocyte-derived EV release^[1].

Animal Model:	Mice^[1].
Dosage:	10?mg/kg.
Administration:	IP 0.5?h prior to IL-1β striatal injection.
Result:	Brain concentrations of DPTIP are above its IC50 for nSMase2 inhibition for at least 4?h after compound administration. The number of astrocyte-derived EVs was reduced by 51?±?13% 2?h post IL-1β administration.

storage

Store at -20°C

References

[1] Camilo Rojas, et al. DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci Rep. 2018 Dec 7;8(1):17715. DOI:10.1038/s41598-018-36144-2
[2] Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330. DOI:10.1080/14756366.2020.1754814

DPTIP Preparation Products And Raw materials

Raw materials

Preparation Products

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DPTIP Suppliers

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351353-48-5, DPTIPRelated Search:

DPTIP

Phenol, 2,6-dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]-

2,6-dimethoxy-4-[5-phenyl-4-(thiophen-2-yl)-1H-im idazol-2-yl]phenol

extracellular,Inhibitor,exosome,DPTIP,Phospholipase,vesicles,inhibit,N-SMase

DPTIP, 10 mM in DMSO

2,6-Dimethoxy-4-(4-phenyl-5-(thiophen-2-yl)-1H-imidazol-2-yl)phenol

351353-48-5