JCN037

Product Name: JCN037
CAS No.: 2305154-31-6
Chemical Name: JCN037
Synonyms: JCN037;JCN037, 10 mM in DMSO;N-(3-Bromo-2-fluorophenyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine;[1,4]Dioxino[2,3-g]quinazolin-4-amine, N-(3-bromo-2-fluorophenyl)-7,8-dihydro-;JCN037,Epidermal growth factor receptor,HER1,Inhibitor,JCN-037,JCN 037,inhibit,EGFR,JGK-037,ErbB-1,JGK037,JGK 037
CBNumber: CB86187891
Molecular Formula: C16H11BrFN3O2
Formula Weight: 376.18
MOL File: 2305154-31-6.mol

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JCN037 Property

Boiling point:: 466.1±45.0 °C(Predicted)
Density: 1.669±0.06 g/cm3(Predicted)
solubility: DMSO:250.0(Max Conc. mg/mL);664.57(Max Conc. mM)
pka: 5.55±0.20(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0129398
Product name: JCN037
Purity: ≥98.0%
Packaging: 5mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-0129398
Product name: JCN037
Purity: ≥98.0%
Packaging: 10mg
Price: $280
Updated: 2021/12/16

ChemScene

Product number: CS-0129398
Product name: JCN037
Purity: ≥98.0%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0129398
Product name: JCN037
Purity: ≥98.0%
Packaging: 100mg
Price: $1250
Updated: 2021/12/16

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JCN037 Chemical Properties,Usage,Production

Uses

JCN037 (JGK037) is non-covalent and BBB-penetrant EGFR tyrosine kinase inhibitor, with IC50 values of 2.49 nM, 3.95 nM, 4.48 nM for EGFR, p-wtEGFR and pEGFRvⅢ, respectively[1].

in vivo

JCN037 (compound 5) exhibits low oral bioavailability due to a rapid hydroxylation of the fused 1,4-dioxane ring, suggesting first pass metabolism^[1].
JCN037 (compound 5, 300 mg/kg, BID) treatment provides a significant survival benefit, whereby median survival increased by 47% from 37.5 days to 55 days with 5 treatment^[1].

References

[1] Jonathan E. Tsang, et al. Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors. ACS Med. Chem. Lett. 2020. May 1.

JCN037 Preparation Products And Raw materials

Raw materials

Preparation Products

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JCN037 Suppliers

China 23 United States 3 Global 26

Sichuan Wei Keqi Biological Technology Co., Ltd.

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2305154-31-6, JCN037Related Search:

JCN037

[1,4]Dioxino[2,3-g]quinazolin-4-amine, N-(3-bromo-2-fluorophenyl)-7,8-dihydro-

JCN037,Epidermal growth factor receptor,HER1,Inhibitor,JCN-037,JCN 037,inhibit,EGFR,JGK-037,ErbB-1,JGK037,JGK 037

N-(3-Bromo-2-fluorophenyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine

JCN037, 10 mM in DMSO

2305154-31-6