ChemicalBook > CAS DataBase List > METFORMIN-D6, HYDROCHLORIDE

METFORMIN-D6, HYDROCHLORIDE

Product Name: METFORMIN-D6, HYDROCHLORIDE
CAS No.: 1185166-01-1
Chemical Name: METFORMIN-D6, HYDROCHLORIDE
Synonyms: Metformin-d;metformin d6;Diabetosan-d6;Metiguanide-d6;Metformine-D6.HCl;Diabex-d6, Glucophage-d6;Metformin Impurity 9 HCl;METFORMIN-D6, HYDROCHLORIDE;Metformin hydrochloride salt;[2H6]-Metformin hydrochloride
CBNumber: CB8649272
Molecular Formula: C4H6ClD6N5
Formula Weight: 171.661550668
MOL File: Mol file

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METFORMIN-D6, HYDROCHLORIDE Property

Melting point:: 215-218°C
storage temp.: -20°C Freezer
solubility: Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
InChI: InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H/i1D3;/hD3
InChIKey: OETHQSJEHLVLGH-MIOFBDNISA-N
SMILES: N([2H])([2H])C(=N)N([2H])C(=N)N(C)C([2H])([2H])[2H].[H]Cl
CAS Number Unlabeled: 1115-70-4

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 53183
Product name: Metformin-(dimethyl-d6) hydrochloride
Purity: analytical standard
Packaging: 5mg
Price: $661
Updated: 2025/07/31

Cayman Chemical

Product number: 16921
Product name: Metformin-d6 (hydrochloride)
Purity: ≥98% deuterated forms (d1-d6)
Packaging: 500μg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 16921
Product name: Metformin-d6 (hydrochloride)
Purity: ≥98% deuterated forms (d1-d6)
Packaging: 1mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 16921
Product name: Metformin-d6 (hydrochloride)
Purity: ≥98% deuterated forms (d1-d6)
Packaging: 5mg
Price: $469
Updated: 2024/03/01

Usbiological

Product number: M3009-75
Product name: Metformin-d6, Hydrochloride
Packaging: 1mg
Price: $382
Updated: 2021/12/16

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METFORMIN-D6, HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Metformin-d₆ is intended for use as an internal standard for the quantification of metformin by GC- or LC-MS. Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice when administered at doses of 10 or 50 mg/kg per day. It also reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of non-alcoholic fatty liver disease (NAFLD). Metformin (250 mg/kg) reduces tumor growth in an HCT116 p53^-\- human colon cancer mouse xenograft model, but has no effect on HCT116 p53^-\- tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, a single-subunit ortholog of the multi-subunit mammalian mitochondrial complex I. Formulations containing metformin have been used in the treatment of type 2 diabetes.

Chemical Properties

White Crystalline Solid

Uses

An oral hypoglycemic agent.

IC 50

AMPK

References

[1] BENOIT VIOLLET. Cellular and molecular mechanisms of metformin: an overview.[J]. Clinical science, 2012, 122 6: 253-270. DOI: 10.1042/cs20110386
[2] REUBEN J. SHAW. The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin[J]. Science, 2005, 310 5754. DOI: 10.1126/science.1120781
[3] WILLIAM W WHEATON. Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis.[J]. eLife, 2014: e02242. DOI: 10.7554/elife.02242
[4] EUN KYUNG KIM. Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21[J]. Mediators of Inflammation, 2016, 42 1. DOI: 10.1155/2016/5813030
[5] MIN-JIE LIN. Metformin improves nonalcoholic fatty liver disease in obese mice via down-regulation of apolipoprotein A5 as part of the AMPK/LXRα signaling pathway.[J]. Oncotarget, 2017, 8 65: 108802-108809. DOI: 10.18632/oncotarget.22163

METFORMIN-D6, HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1185166-01-1, METFORMIN-D6, HYDROCHLORIDERelated Search:

7-Methoxycoumarin 2-METHOXY-D3-PHENOL NABUMETONE-D3 TOPIRAMATE-D12 Veratric Acid-d6 Metformin D6

Metformin-(dimethyl-d6) hydrochloride

Metformine-D6.HCl

[2H6]-Metformin hydrochloride

1,1-Di(methyl-d3)biguanide hydrochloride

METFORMIN-D6, HYDROCHLORIDE

Diabetosan-d6

Diabex-d6, Glucophage-d6

Metiguanide-d6

N,N-Dimethylimidodicarbonimidic Diamide-d6, Hydrochloride

3-(diaminomethylidene)-1,1-bis(trideuteriomethyl)guanidine,hydrochloride

Metformin-d6 hydrochloride (dimethyl-d6)

METFORMIN:HCL (DIMETHYL-D6, 99%)

1,1-Dimethyl-d6-biguanide HCl

metformin d6

Metformin hydrochloride salt

Metformin D6 HydrochlorideQ: What is Metformin D6 Hydrochloride Q: What is the CAS Number of Metformin D6 Hydrochloride Q: What is the storage condition of Metformin D6 Hydrochloride Q: What are the applications of Metformin D6 Hydrochloride

1,1-Dimethylbiguanide-d6 hydrochloride

N,N-Di(methyl-d3)-imidodicarbonimidic diamide hydrochloride

Metformin Impurity 9 HCl

Metformin-d

Metformin-(<i>dimethyl</i>-d<sub>6</sub>) hydrochloride

Metformin D6 (dimethyl D6) hydrochloride

Metformin·HCl (dimethyl-D?, 99%)

1185166-01-1

185166-01-1

C4H6D6ClN5

Intermediates & Fine Chemicals

Isotope Labeled Compounds

Pharmaceuticals

Isotope Labelled Compounds