METHYL 3-(2-PYRROLYL)PROPANOATE
- Product Name
- METHYL 3-(2-PYRROLYL)PROPANOATE
- CAS No.
- 69917-80-2
- Chemical Name
- METHYL 3-(2-PYRROLYL)PROPANOATE
- Synonyms
- 3-(1H-pyrroL;Methyl 1H-pyrrole-2-propanoate;Methyl-3-(2-pyrrolyl)propionate;METHYL 3-(2-PYRROLYL)PROPANOATE;2-(2-Methoxycarbonylethyl)pyrrole;METHYL 3-(1H-PYRROL-2-YL)PROPANOATE;1H-Pyrrole-2-propanoic Acid Methyl Ester;3-(1H-pyrrol-2-yl)-propionic acid methyl ester;Methyl 3-(2-pyrrolyl)propionate [ 2-(2-Methoxycarbonylethyl)pyrrole]
- CBNumber
- CB8649489
- Molecular Formula
- C8H11NO2
- Formula Weight
- 153.18
- MOL File
- 69917-80-2.mol
METHYL 3-(2-PYRROLYL)PROPANOATE Property
- Boiling point:
- 75°C/0/3mmHg.
- Density
- 1.117
- Flash point:
- 105℃
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), Methanol (Sparingly)
- form
- Oil
- pka
- 17.34±0.50(Predicted)
- color
- Dark Beige Low-Melting Solid to Pale Orange to Orange
- InChI
- InChI=1S/C8H11NO2/c1-11-8(10)5-4-7-3-2-6-9-7/h2-3,6,9H,4-5H2,1H3
- InChIKey
- UBOXXEGSGUIRAJ-UHFFFAOYSA-N
- SMILES
- N1C=CC=C1CCC(OC)=O
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M325949
- Product name
- Methyl3-(2-Pyrrolyl)propanoate
- Packaging
- 500mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- W7965
- Product name
- Methyl3-(1H-pyrrol-2-yl)propanoate
- Packaging
- 5g
- Price
- $733
- Updated
- 2021/12/16
- Product number
- 4H23-1-8N
- Product name
- Methyl 3-(1H-pyrrol-2-yl)propanoate
- Packaging
- 1g
- Price
- $756
- Updated
- 2021/12/16
- Product number
- 118123
- Product name
- Methyl 3-(1H-pyrrol-2-yl)propanoate
- Packaging
- 1g
- Price
- $759
- Updated
- 2021/12/16
- Product number
- 12192
- Product name
- Methyl3-(2-Pyrrolyl)propanoate
- Packaging
- 1g
- Price
- $860
- Updated
- 2021/12/16
METHYL 3-(2-PYRROLYL)PROPANOATE Chemical Properties,Usage,Production
Chemical Properties
Clear to Light Yellow Liquid
Uses
Methyl 3-(2-Pyrrolyl)propanoate (cas# 69917-80-2) is a compound useful in organic synthesis.
Synthesis
32585-91-4
69917-80-2
The general procedure for the synthesis of methyl 3-(2-pyrrolyl)propionate from methyl (E)-3-(1H-pyrrol-2-yl)acrylate was as follows: methyl (E)-3-(1H-pyrrol-2-yl)acrylate (3.15 g, 21.1 mmol) was dissolved in methanol (160 mL) under argon protection. Palladium/carbon catalyst (246 mg, 10%) was added to the solution, followed by replacement of argon with hydrogen. The reaction mixture was stirred at room temperature until thin layer chromatography (TLC) analysis showed that the reaction was complete (about 16 hours). Upon completion of the reaction, the crude product was filtered through a bed of diatomaceous earth and the diatomaceous earth plug was washed with methanol (50 mL). The combined methanol washings were concentrated under vacuum to afford methyl 3-(2-pyrrolyl)propionate (3.13 g, 100%) as a light yellow oil, which did not require further purification. The nuclear magnetic resonance (NMR) data of the resulting product were consistent with those reported in the literature.1H NMR (CDCl3, 400 MHz) δ: 8.53 (1H, broad single peak), 6.69-6.68 (1H, multiple peaks), 6.13-6.10 (1H, multiple peaks), 5.94-5.93 (1H, multiple peaks), 3.71 (3H, single peak), 2.93 ( 2H, triple peak, J = 6.6Hz), 2.66 (2H, triple peak, J = 6.6Hz).13C NMR (CDCl3, 100MHz) δ: 174.5, 130.9, 116.8, 108.0, 105.5, 51.8, 34.4, 22.5.
References
[1] Tetrahedron, 2013, vol. 69, # 39, p. 8527 - 8533
[2] Chemistry - A European Journal, 2018, vol. 24, # 19, p. 4957 - 4966
[3] European Journal of Organic Chemistry, 2010, # 19, p. 3611 - 3620
[4] Journal of the American Chemical Society, 2017, vol. 139, # 44, p. 15801 - 15811
METHYL 3-(2-PYRROLYL)PROPANOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 3-(2-PYRROLYL)PROPANOATE manufacturers
- Product
- Methyl 3-(1H-pyrrol-2-yl)propanoate 69917-80-2
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20tons
- Release date
- 2019-12-30