4-BROMOMETHYL-2-CHLORO-1-METHOXYBENZENE

Product Name: 4-BROMOMETHYL-2-CHLORO-1-METHOXYBENZENE
CAS No.: 320407-92-9
Chemical Name: 4-BROMOMETHYL-2-CHLORO-1-METHOXYBENZENE
Synonyms: RSYY（Avanafil)-58;-2-chloro-1-methoxybenzene;3-Chloro-4-Methoxybenzyl broMide;4-BROMOMETHYL-2-CHLORO-1-METHOXYBENZENE;Benzene, 4-(bromomethyl)-2-chloro-1-methoxy-
CBNumber: CB8676104
Molecular Formula: C8H8BrClO
Formula Weight: 235.51
MOL File: 320407-92-9.mol

More

Less

4-BROMOMETHYL-2-CHLORO-1-METHOXYBENZENE Property

Boiling point:: 273.0±25.0 °C(Predicted)
Density: 1.520±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid

More

Less

Safety

RIDADR: UN3261
HazardClass: 8
HS Code: 2909309090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B697125
Product name: 4-Bromomethyl-2-chloro-1-methoxybenzene
Packaging: 1g
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2707-D-0A
Product name: 3-Chloro-4-methoxybenzyl bromide
Packaging: 1g
Price: $144
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB34114
Product name: 4-Bromomethyl-2-chloro-1-methoxybenzene
Packaging: 1g
Price: $153
Updated: 2021/12/16

Matrix Scientific

Product number: 119317
Product name: 4-(Bromomethyl)-2-chloro-1-methoxybenzene
Purity: 95+%
Packaging: 1g
Price: $162
Updated: 2021/12/16

AK Scientific

Product number: J97599
Product name: 4-Bromomethyl-2-chloro-1-methoxybenzene
Packaging: 5g
Price: $175
Updated: 2021/12/16

More

Less

4-BROMOMETHYL-2-CHLORO-1-METHOXYBENZENE Chemical Properties,Usage,Production

Synthesis

22002-44-4

320407-92-9

General procedure for the synthesis of 4-bromomethyl-2-chloro-1-methoxybenzene from 2-chloro-1-methoxy-4-methylbenzene: 2-chloro-1-methoxy-4-methylbenzene (2.6 mL, 19.2 mmol) was dissolved in dichloromethane (30 mL) and N-bromosuccinimide (3.75 g, 21.1 mmol) and AIBN (36.0 mg). The reaction mixture was heated to reflux, kept for 19 h and then cooled to room temperature and filtered to remove the precipitate. The filtrate was diluted with dichloromethane and washed sequentially with 0.5 M aqueous sodium bicarbonate and water. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 4-bromomethyl-2-chloro-1-methoxybenzene (4.73 g, 82% yield). The crude product (benzyl bromide) could be used for subsequent reaction without further purification.1H NMR (400 MHz, CDCl3): δ 7.42 (d, 1H, J = 2.4 Hz), 7.26 (dd, 1H, J = 2.4 Hz, J = 8.4 Hz), 6.88 (d, 1H, J = 8.4 Hz), 4.44 (s, 2H), 3.90 (s. 3H).

References

[1] Patent: US2002/169174, 2002, A1
[2] European Journal of Organic Chemistry, 2005, # 2, p. 317 - 325
[3] Patent: WO2012/7868, 2012, A2. Location in patent: Page/Page column 94-95
[4] Patent: US2007/88053, 2007, A1. Location in patent: Page/Page column 19

4-BROMOMETHYL-2-CHLORO-1-METHOXYBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-BROMOMETHYL-2-CHLORO-1-METHOXYBENZENE Suppliers

China 49 India 2 United Kingdom 3 United States 9 Global 63

Beijing Eternalchem Co,. Ltd.

Tel: 010-59484199 18611897322
Email: sales@eternalchem.com
Country: China
ProdList: 4383
Advantage: 60

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8026
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 42446
Advantage: 60

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7992
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai CR Corporation Limited

Tel: 13062833949; 4006653949 4006653949
Fax: QQ: 2136646215
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 9757
Advantage: 58

320407-92-9, 4-BROMOMETHYL-2-CHLORO-1-METHOXYBENZENERelated Search:

METHYL 2-(4-(BROMOMETHYL)-2-CHLOROPHENOXY)ACETATE 3-CHLORO-4-(TRIFLUOROMETHOXY)BENZYL BROMIDE 4-BROMOMETHYL-2-CHLORO-1-METHOXYBENZENE 5-(bromomethyl)-1,3-dichloro-2-methoxybenzene 3-CHLORO-5-FLUORO-4-METHOXYBENZYL BROMIDE

4-BROMOMETHYL-2-CHLORO-1-METHOXYBENZENE

3-Chloro-4-Methoxybenzyl broMide

-2-chloro-1-methoxybenzene

Benzene, 4-(bromomethyl)-2-chloro-1-methoxy-

RSYY（Avanafil)-58

320407-92-9

C8H8OClBr

pharmacetical