Trandolapril

ChemicalBook > CAS DataBase List > Trandolapril

Product Name: Trandolapril
CAS No.: 87679-37-6
Chemical Name: Trandolapril
Synonyms: Mavik;Odrik;Odric;Udrik;Gopten;Preran;ru44570;Trantowa;Olivetolic;Ccris 6594
CBNumber: CB8682356
Molecular Formula: C24H34N2O5
Formula Weight: 430.54
MOL File: 87679-37-6.mol

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Trandolapril Property

Melting point:: 122-123°C
Boiling point:: 626.0±55.0 °C(Predicted)
Density: 1.181±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥20mg/mL
form: white powder
pka: 3.15±0.20(Predicted)
color: White to Off-White
CAS DataBase Reference: 87679-37-6(CAS DataBase Reference)

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Safety

WGK Germany: 3
RTECS: NL6015178
HS Code: 2933995300
Hazardous Substances Data: 87679-37-6(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T4827
Product name: Trandolapril
Purity: ≥98% (HPLC), white powder
Packaging: 10mg
Price: $71.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR3146
Product name: Trandolapril
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 250MG
Price: $200
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP1089
Product name: Trandolapril
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 200MG
Price: $257
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1672687
Product name: Trandolapril
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 125mg
Price: $436
Updated: 2024/03/01

Cayman Chemical

Product number: 13522
Product name: Trandolapril
Purity: ≥98%
Packaging: 25mg
Price: $121
Updated: 2024/03/01

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Trandolapril Chemical Properties,Usage,Production

Description

Trandolapril is a new ACE inhibitor that is rapidly hydrolyzed, mainly in the liver, to its biologically active form, trandolaprilat. Compared with all other ACE inhibitors, trandolaprilat is reported to have the highest lipophilicity and the most prolonged ACE inhibitory activity. In hypertensive patients, trandolapril at a dose of 2 mg reduces blood pressure consistently throughout the 24 hour period after intake, making it one of the best once a day antihypertensive drugs. It has also been demonstrated to inhibit aortic atherosclerosis in the hyperlipidemic rabbit.

Chemical Properties

White or almost white powder.

Originator

Roussel Uclaf (France)

Uses

Trandolapril has been used as an angiotensin-converting enzyme (ACE) inhibitor to study its effects on responsiveness of human retinal endothelial cells (HRECs) to vascular endothelial growth factor (VEGF).

Uses

An antihypertensive. Angiotensin converting enzyme (ACE) inhibitor

Uses

antibacterial

Definition

ChEBI: Trandolapril is a heterobicylic compound that is (2S,3aR,7aS)-1-[(2S)-2-aminopropanoyl]octahydro-1H-indole-2-carboxylic acid in which the hydrogen of the amino group is substituted by a (2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl group. It is a angiotensin-converting enzyme inhibitor and a prodrug used for the treatment of hypertension. It has a role as a prodrug, an antihypertensive agent and an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It is a dicarboxylic acid monoester, a dipeptide, an ethyl ester, a secondary amino compound, a tertiary carboxamide and an organic heterobicyclic compound. It is functionally related to a trandolaprilat.

brand name

Odrik; Udrik; Gopten

General Description

Trandolapril, 1-[2-(1-ethoxycarbonyl-3-phenylpropylamino)propionyl]octahydroindole-2-carboxylicacid (Mavik), is an indole-containing ACE inhibitorthat is structurally related to most of the precedingagents discussed. Enalapril is very similar to trandolapril,with the primary difference occurring in the heterocyclicsystems. The pyrrolidine of enalapril has been replacedwith an octahydroindole system. Much like enalaprilate,trandolapril must be hydrolyzed to tranolaprilate, which isthe bioactive species.

Biochem/physiol Actions

Trandolapril is an ACE inhibitor. Trandolapril differs from other ACE inhibitors in that it has a longer biological half-life and a high degree of lipophilicity.

Clinical Use

Angiotensin converting enzyme inhibitor:
Hypertension
Heat failure
After myocardial infarction

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: antagonism of hypotensive effect and increased risk of renal impairment with NSAIDs; hyperkalaemia with ketorolac and other NSAIDs.
Antihypertensives: increased risk of hyperkalaemia, hypotension and renal failure with ARBs and aliskiren.
Bee venom extract: possible severe anaphylactoid reactions when used together.
Ciclosporin: increased risk of hyperkalaemia and nephrotoxicity.
Cytotoxics: increased risk of angioedema with everolimus.
Diuretics: enhanced hypotensive effect; hyperkalaemia with potassium-sparing diuretics.
ESAs: increased risk of hyperkalaemia; antagonism of hypotensive effect.
Gold: flushing and hypotension with sodium aurothiomalate.
Lithium: reduced excretion (possibility of enhanced lithium toxicity).
Potassium salts: increased risk of hyperkalaemia.
Tacrolimus: increased risk of hyperkalaemia and nephrotoxicity.

Metabolism

Trandolapril is metabolised in the liver to the active trandolaprilat and to some inactive metabolites. About 33
% of an oral dose of trandolapril is excreted in the urine, mainly as trandolaprilat; the rest is excreted in the faeces.

Trandolapril Preparation Products And Raw materials

Raw materials

1-Hydroxybenzotriazole N,N-Dimethylformamide N-Ethylmorpholine Dicyclohexylcarbodiimide

Preparation Products

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View Lastest Price from Trandolapril manufacturers

Hebei Dangtong Import and export Co LTD

Product: Trandolapril 87679-37-6
Price: US $560.00-555.00/Grams
Min. Order: 10Grams
Purity: 99%
Supply Ability: 100Tons
Release date: 2023-03-03

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Trandolapril 87679-37-6
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.10%
Supply Ability: 50000kg
Release date: 2024-04-25

Hebei Mojin Biotechnology Co., Ltd

Product: Trandolapril 87679-37-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000000kg
Release date: 2023-08-04

87679-37-6, TrandolaprilRelated Search:

DIETHOXYMETHANE PHENYL VALERATE 4-Ethoxyphenol Phenetidine Diethoxymethyl acetate Propyl butyrate Ethoxyquin Phenylhydrazine 2-Ethoxyphenol acetic acid, triethoxy-, ethyl ester Propyl gallate Trandolapril-d5 Trandolaprilat ZOPICLONE OXIDE Zopiclone Trandolapril Acyl--D-glucuronide, 85% TRANDOLAPRIL-PHENYL-D5 TRANDOLAPRIL IMPURITY D

(2s-(1(r*(r*)),2-alpha,3a-alpha,7a-beta))-)amino)-1-oxopropyl)

ru44570

(2s,3ar,7as)-1-[(2s)-2-[[(1s)-1-ethoxycarbonyl-3-phenyl-propyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid

Mavik, (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-Indole-2-carboxylic acid

(3αR．7αS)-1-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropy]-(S)-alanyl]oetahydroindole-2(S)-carboxylic acid

TrandolaprilC24H34N205

Mavik, Odrik, Gopten, RU-44570

1H-Indole-2-carboxylic acid, 1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, (2S,3aR,7aS)- (9CI)

1H-Indole-2-carboxylic acid, 1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, [2S-[1[R*(R*)],2a,3aa,7ab]]-

Gopten

Odrik

Trandolapril／(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid

(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-Indole-2-carboxylic Acid

Mavik

TRANDOLAPRIL

Olivetolic

1H-Indole-2-carboxylic acid, octahydro-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1- oxopropyl)-, (2S-(1(R*(R*)),2-alpha,3a-alpha,7a-beta))

(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]propionyl]-3a,4,5,6,7,7a-hexahydro-2-indolinecarboxylic acid

(2S,3aR,7aS)-1-[(S)-N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]alanyl]octahydro-1H-indole-2-carboxylic acid

Odric

Trantowa

(2S,3Ar,7as)-1-((S)-N-((S)-1-carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester

1H-Indole-2-carboxylic acid, 1-((2S)-2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydro-, (2S,3ar,7as)-

Ccris 6594

Trandolapril (125 mg)

(2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aMino}propanoyl]-octahydro-1H-indole-2-carboxylic acid

Preran

Tarka(coMb. with verapaMil)

Udrik

(2S,3aR,7aS)-

1H-Indole-2-carboxylicacid,1-[(2S)-2-[[(1S)-

(2S,3aR,7aS)-1-((S)-2-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)aMino)propanoyl)octahydro-1H-indole-2-carboxylic acid

1H-Indole-2-carboxylicacid,1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]aMino]-1-oxopropyl]octahydro-,(2S,3aR,7aS)-

Trandolapril Ph. Eur.

(2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid

Trandolapril Solution, 1000ppm

Trandolapril Solution, 100ppm

Trandolapril CRS

Trandolapril USP/EP/BP

Trandolapril (RU44570)

Trandolapril D6

TrandolaprilQ: What is Trandolapril Q: What is the CAS Number of Trandolapril Q: What is the storage condition of Trandolapril Q: What are the applications of Trandolapril

Trandolapril (1672687)

RU-44570,collagen,UUD model,inhibit,arterial hypertrophy,congestive heart failure,cellular fibronectin accumulation,Angiotensin-converting Enzyme (ACE),hypertension,CHF,RU 44570,spontaneously hypertensive rats,RU44570,Trandolapril,Inhibitor,UUO model,orally active,nonsulfhydryl,myocardial infarction,unilateral ureteral obstruction,Trandolaprilat

87679-37-6

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