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ChemicalBook > CAS DataBase List > 1-Tetradecanol

1-Tetradecanol

Description References
Product Name
1-Tetradecanol
CAS No.
112-72-1
Chemical Name
1-Tetradecanol
Synonyms
MYRISTYL ALCOHOL;myristic;Tetradecan-1-ol;myristyl;Loxanol V;Lanette 14;MYRISTIC ALCOHOL;TETRADECYL ALCOHOL;alfol14;Epal 14
CBNumber
CB8689436
Molecular Formula
C14H30O
Formula Weight
214.39
MOL File
112-72-1.mol
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1-Tetradecanol Property

Melting point:
35-39 °C(lit.)
Boiling point:
289 °C(lit.)
Density 
0.823 g/mL at 25 °C(lit.)
vapor density 
7.4 (vs air)
vapor pressure 
<1 hPa (20 °C)
refractive index 
1.4454
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
water: soluble0.00013g/L at 23°C
form 
Low Melting Solid, Crystalline Powder, Crystals, Flakes, Pellets and/or Chunks
pka
15.20±0.10(Predicted)
Specific Gravity
0.823
color 
White
Odor
fatty
Odor Type
waxy
Water Solubility 
insoluble
Merck 
14,6335
BRN 
1742652
Dielectric constant
4.4(48℃)
LogP
5.5
CAS DataBase Reference
112-72-1(CAS DataBase Reference)
NIST Chemistry Reference
1-Tetradecanol(112-72-1)
EPA Substance Registry System
1-Tetradecanol (112-72-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
38-36
Safety Statements 
24/25-26
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
-
RTECS 
XB8655000
9
Autoignition Temperature
489 °F
TSCA 
Yes
HS Code 
2905 19 00
HazardClass 
9
PackingGroup 
III
Hazardous Substances Data
112-72-1(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rabbit > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.08146
Product name
1-Tetradecanol
Purity
for synthesis
Packaging
100g
Price
$58.4
Updated
2024/03/01
Sigma-Aldrich
Product number
8.08146
Product name
1-Tetradecanol
Purity
for synthesis
Packaging
1kg
Price
$115
Updated
2024/03/01
Sigma-Aldrich
Product number
8.08146
Product name
1-Tetradecanol
Purity
for synthesis
Packaging
50kg
Price
$1340
Updated
2024/03/01
Sigma-Aldrich
Product number
185388
Product name
1-Tetradecanol
Purity
97%
Packaging
100g
Price
$65.3
Updated
2024/03/01
TCI Chemical
Product number
T0084
Product name
1-Tetradecanol
Purity
>98.0%(GC)
Packaging
25mL
Price
$16
Updated
2024/03/01
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1-Tetradecanol Chemical Properties,Usage,Production

Description

1-Tetradecanol is a kind of straight-chain saturated fatty alcohol. It is often used as an ingredient in cosmetics such as cold creams because of its emollient properties. It can also be used as the intermediate during the manufacturing of some organic compounds like surfactants. Some studies have shown that it can inhibit the endothelial activation and reduce tissue responsiveness to cytokines, having the potential to treat the periodontitis based on studies on rabbits. It is also employed for the fabrication of temperature-regulated drug release system based on phase-change materials.

References

Lehmler, Hans-Joachim, and Paul M. Bummer. "Behavior of 10-(perfluorohexyl)-decanol, a partially fluorinated analog of hexadecanol, at the air–water interface." Journal of fluorine chemistry 117.1 (2002): 17-22.
Hasturk, Hatice, et al. "1-Tetradecanol complex reduces progression of porphyromonas gingivalis–induced experimental periodontitis in rabbits." Journal of periodontology 78.5 (2007): 924-932.
Hasturk, H, et al. "1-Tetradecanol complex: therapeutic actions in experimental periodontitis." Journal of Periodontology 80.7(2009): 1103-13.
Choi, Sung-Wook, Yu Zhang, and Younan Xia. "A temperature-sensitive drug release system based on phase-change materials." Angewandte Chemie International Edition 49.43 (2010): 7904-7908.

Chemical Properties

white low melting solid or flakes

Chemical Properties

Myristyl alcohol occurs as a white crystalline solid with a waxy odor. Also reported as opaque leaflets or crystals from ethanol.

Uses

myristyl alcohol is an emollient often used in hand creams, cold creams, and lotions to give them a smooth, velvety feel. Sources indicate it as being mildly comedogenic and potentially irritating.

Uses

1-Tetradecanol is used as an ingredient in cosmetics such as cold creams. It is an active intermediate in the chemical synthesis of sulfated alcohol. It is also employed in the fabrication of temperature-regulated drug release system based on phase-change materials. It plays a vital role in filling the hollow interiors of gold nanocages in the fabrication of new theranostic system, which has unique feature of photoacoustic imaging.

Uses

As emollient for cold creams, etc., also for making the sulfated alcohol whose sodium salt is applicable as a "wetter" in textiles.

Production Methods

Myristyl alcohol is found in spermaceti wax and sperm oil, and may be synthesized by sodium reduction of fatty acid esters or the reduction of fatty acids by lithium aluminum hydride. It can also be formed from acetaldehyde and dimethylamine.

Definition

ChEBI: 1-Tetradecanol is a long-chain fatty alcohol that is tetradecane in which one of the terminal methyl hydrogens is replaced by a hydroxy group It is a long-chain primary fatty alcohol, a fatty alcohol 14:0 and a primary alcohol.

Synthesis Reference(s)

The Journal of Organic Chemistry, 35, p. 1210, 1970 DOI: 10.1021/jo00829a089

General Description

Colorless thick liquid (heated) with a faint alcohol odor. Solidifies and floats on water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

1-Tetradecanol is an alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Health Hazard

Low toxicity. Overexposure causes some central nervous system depression. Prolonged skin contact causes skin irritation.

Flammability and Explosibility

Not classified

Pharmaceutical Applications

Myristyl alcohol is used in oral, parenteral, and topical pharmaceutical formulations. It has been evaluated as a penetration enhancer in melatonin transdermal patches in rats.
Myristyl alcohol has also been tested as a bilayer stabilizer in niosome formulations containing ketorolac tromethamine,and zidovudine.Niosomes containing myristyl alcohol showed a considerably slower release rate of ketorolac tromethamine than those containing cholesterol.This was also observed with the zidovudine formulation.

Safety

Myristyl alcohol is used in oral parenteral, and topical pharmaceutical formulations. The pure form of myristyl alcohol is mildly toxic by ingestion and may be carcinogenic; experimental tumorigenic data are available.It is also a human skin irritant. In animal studies of the skin permeation enhancement effect of saturated fatty alcohols, myristyl alcohol exhibited a lower effect when compared with decanol, undecanol, or lauryl alcohol but caused greater skin irritation.A study investigating contact sensitization to myristyl alcohol revealed that patch testing of myristyl alcohol 10% petrolatum should not be carried out owing to observed irritant effects; thus the use of a lower concentration of myristyl alcohol for such tests (5% petrolatum) was recommended.Myristyl alcohol has been associated with some reports of contact allergy.(8,9)A moderate-to-severe erythema and moderate edema are seen when 75 mg is applied to human skin intermittently in three doses over 72 hours.
LD50(rabbit, skin): 7.1 g/kg
LD50(rat, oral): 33.0 g/kg

storage

The bulk material should be stored in a well-closed container in a cool, dry place.

Purification Methods

Crystallise the alcohol from aqueous EtOH. It has also been purified by zone melting. [Beilstein 1 IV 1864.]

Incompatibilities

Myristyl alcohol is combustible when exposed to heat or flame. It can react with oxidizing materials. When heated to decomposition, it emits acrid smoke and irritating fumes.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral tablet: sustained-release; and topical formulations: cream, lotion, suspension). Included in nonparenteral (topical cream) formulations licensed in the UK.

1-Tetradecanol Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Tetradecanol Suppliers

SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.
Tel
021-69106960 13701823733
Fax
021-69106780
Email
13701823733@163.com
Country
China
ProdList
4776
Advantage
60
Shanghai shengyue international trading co., ltd
Tel
021-66690837 13166269258
Email
2570384992@qq.com
Country
China
ProdList
45
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12426
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
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View Lastest Price from 1-Tetradecanol manufacturers

Hebei Yime New Material Technology Co., Ltd.
Product
MYRISTYL ALCOHOL 112-72-1
Price
US $3.00/kg
Min. Order
1000kg
Purity
99%
Supply Ability
1000kg/day
Release date
2023-11-09
Hebei Yime New Material Technology Co., Ltd.
Product
1-Tetradecanol 112-72-1
Price
US $3.00/kg
Min. Order
1000kg
Purity
99%
Supply Ability
1000kg/day
Release date
2023-11-09
Hebei Yime New Material Technology Co., Ltd.
Product
Myristyl Alcohol 112-72-1
Price
US $2.50/kg
Min. Order
100kg
Purity
99%
Supply Ability
1000kg/day
Release date
2023-11-15

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