ChemicalBook > CAS DataBase List > L(+)-allo-Threonine

L(+)-allo-Threonine

Product Name
L(+)-allo-Threonine
CAS No.
28954-12-3
Chemical Name
L(+)-allo-Threonine
Synonyms
Allo-Thr-OH;H-ALLO-THR-O;H-ALLO-THR-OH;L-allo-Thr-OH;l-allothreonin;ALLO-THREONINE;H-L-ALLO-THR-OH;L-ALLO-THREONINE;allo-l-threonine;H-ALLO-THR(BUT)-OH
CBNumber
CB8691943
Molecular Formula
C4H9NO3
Formula Weight
119.12
MOL File
28954-12-3.mol
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L(+)-allo-Threonine Property

Melting point:
272 °C (dec.)(lit.)
alpha 
9 º (c=2, H2O)
Boiling point:
222.38°C (rough estimate)
Density 
1.3126 (rough estimate)
refractive index 
10 ° (C=5, H2O)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Water (Slightly)
pka
pK1: 2.108(+1);pK2: 9.096(0) (25°C)
form 
Crystalline Powder
color 
White to off-white
optical activity
[α]23/D +9.0°, c = 2 in H2O
BRN 
1721645
InChI
InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3-/m0/s1
InChIKey
AYFVYJQAPQTCCC-HRFVKAFMSA-N
SMILES
C(O)(=O)[C@H]([C@@H](O)C)N
CAS DataBase Reference
28954-12-3(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
3
RTECS 
BA4055000
HS Code 
29225090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
210269
Product name
L-allo-Threonine
Purity
99%
Packaging
250MG
Price
$404
Updated
2023/01/07
TCI Chemical
Product number
A1519
Product name
L-Allothreonine
Purity
>99.0%(HPLC)
Packaging
1g
Price
$455
Updated
2025/07/31
TCI Chemical
Product number
A1519
Product name
L-Allothreonine
Purity
>99.0%(HPLC)
Packaging
100mg
Price
$125
Updated
2025/07/31
TRC
Product number
A548535
Product name
L-allo-Threonine
Packaging
250mg
Price
$130
Updated
2021/12/16
Usbiological
Product number
239137
Product name
L-allo-Threonine 99+%
Packaging
250mg
Price
$237
Updated
2021/12/16
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L(+)-allo-Threonine Chemical Properties,Usage,Production

Chemical Properties

white to off-white crystalline powder

Uses

L-allo-Threonine is a reactant used in the synthesis of an antibiotic, globomycin, and its congener, SF-1902 A5.

Definition

ChEBI: L-allothreonine is the L-enantiomer of allothreonine. It has a role as an Escherichia coli metabolite and a Saccharomyces cerevisiae metabolite. It is an allothreonine and a L-alpha-amino acid. It is an enantiomer of a D-allothreonine. It is a tautomer of a L-allothreonine zwitterion.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

64420-00-4

72-19-5

The general procedure for the synthesis of L-threonine from 5-(1-hydroxyethyl)urea (CAS:64420-00-4) is as follows: in a 1 L autoclave, 144 g (1 mol) of 5-(1-hydroxyethyl)urea, 68 g of 25% ammonia, 110 g of calcium hydroxide (1.5 mol), 500 g of water, and 50 mL of n-butanol were added in sequence. The mixture was heated to 160-170°C and the reaction pressure was maintained at 1.5-2.0 MPa for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted by passing carbon dioxide to 8. The reaction mixture was filtered and the mother liquor was concentrated under reduced pressure. To the residue, 150 g of methanol was added and refluxed for 2 h. Crystals were precipitated after cooling. The crystals were collected by filtration, and the filter cake was dried under vacuum at 120°C for 4 h. 106.4 g of 2-amino-3-hydroxybutyric acid was obtained with a purity of 96% and a yield of 89.4%.

References

[1] Patent: CN104892521, 2018, B. Location in patent: Paragraph 0069; 0070

L(+)-allo-Threonine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from L(+)-allo-Threonine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
L-Allothreonine 28954-12-3
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg
Release date
2021-08-28
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
H-L-allo-Thr-OH 28954-12-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1T
Release date
2023-09-25
Hebei Chuanghai Biotechnology Co., Ltd
Product
L(+)-allo-Threonine 28954-12-3
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-05

28954-12-3, L(+)-allo-ThreonineRelated Search:

4-Aminobutyric acid ALTRENOGEST L-Threonine DL-4-Amino-3-hydroxybutyric acid 3-Hydroxybutyric acid Glycine L-Alanine H-PHG-OME HCL (S)-(+)-2-Amino-3-hydroxy-3-methylbutanoic acid POLYOXIN B (2S,3S)-2-Amino-3-methoxybutanoic acid TRANS-3-HYDROXY-L-PROLINE MYRIOCIN (2S,3S)-(2S,3R)-2-AMINO-3-HYDROXY-4-METHYLPENTANOIC ACID (2R,3R)-(-)-ALLO-THREONINE,D(-)-ALLO-THREONINE,D-ALLO-THREONINE DL-ALLO-THREONINE FMOC-ALLO-THR(TBU)-OH H-ALLO-THR(TBU)-OH,ALLO-THREONINE(TBU)-OH,O-T-BUTYL-L-ALLO-THREONINE

  • l-allothreonin
  • O-T-BUTYL-L-ALLO-THREONINE
  • H-ALLO-THR(BUT)-OH
  • H-ALLO-THR-O
  • H-ALLO-THR-OH
  • H-ALLO-THR(TBU)-OH
  • H-L-ALLO-THR-OH
  • L(+)-ALLO-THREONINE
  • L-ALLO-THREONINE
  • (2S 3S)-(+)-2-AMINO-3-HYDROXYBUTYRIC ACID
  • (2S,3S)-2-AMINO-3-HYDROXYBUTYRIC ACID
  • (2S,3S)-(+)-ALLO-THREONINE
  • ALLO-THREONINE(TBU)-OH
  • ALLO-THREONINE
  • H-allo-Thr-OH(L-Allo-Threonine)
  • Allo-Thr-OH
  • (2S 3S)-(+)-2-AMINO-3-HYDROXYBUTYRIC ACID 99%
  • H-L-allo-Thr(tBu)-OH
  • O-t-Butyl-allo-L-threonine
  • (2S,3S)-3-Hydroxy-2-aminobutanoic acid
  • L(+)-allo-Threonine,99%
  • (2S,3S)-2-Amino-3-hydroxybutyric acid, H-L-allo-Thr-OH
  • L-allo-Thr-OH
  • allo-l-threonine
  • L(+)-allo-Threonine/C4H9NO3
  • L-Allothreonine&gt
  • L(+)-allo-Threonine USP/EP/BP
  • L-Allothreonine (9CI, ACI)
  • <sc>L</sc>-<i>allo</i>-Threonine
  • L-allo-Threonine 98~102%
  • 28954-12-3
  • Unnatural Amino Acid Derivatives
  • Threonine Derivatives
  • Specialty Synthesis
  • Peptide Synthesis
  • amino acid derivative
  • Threonine [Thr, T]
  • Amino Acids