NIGRANOIC ACID
- Product Name
- NIGRANOIC ACID
- CAS No.
- 39111-07-4
- Chemical Name
- NIGRANOIC ACID
- Synonyms
- NIGRANOIC ACID;(3S,3aR,4aS,6aR,7R,9aS,9bS)-7-[(1R,4Z)-5-Carboxy-1-methyl-4-hexen-1-yl]decahydro-6a,9a-dimethyl-3-(1-methylethenyl)-1H-cyclopenta[a]cyclopropa[e]naphthalene-3a(4H)-propanoic acid;1H-Cyclopenta[a]cyclopropa[e]naphthalene-3a(4H)-propanoic acid, 7-[(1R,4Z)-5-carboxy-1-methyl-4-hexen-1-yl]decahydro-6a,9a-dimethyl-3-(1-methylethenyl)-, (3S,3aR,4aS,6aR,7R,9aS,9bS)-
- CBNumber
- CB8693381
- Molecular Formula
- C30H46O4
- Formula Weight
- 470.69
- MOL File
- Mol file
NIGRANOIC ACID Property
- Melting point:
- 128-130 °C
- Boiling point:
- 603.0±28.0 °C(Predicted)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 4.78±0.10(Predicted)
- color
- Off-white to light yellow
N-Bromosuccinimide Price
- Product number
- FN65669
- Product name
- Nigranoic acid
- Packaging
- 1mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FN65669
- Product name
- Nigranoic acid
- Packaging
- 2mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FN65669
- Product name
- Nigranoic acid
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FN65669
- Product name
- Nigranoic acid
- Packaging
- 10mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FN65669
- Product name
- Nigranoic acid
- Packaging
- 25mg
- Price
- $500
- Updated
- 2021/12/16
NIGRANOIC ACID Chemical Properties,Usage,Production
Uses
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model[1][2].
Definition
ChEBI: A tetracyclic triterpenoid that is 3,4-secocycloarta-4(28),24-(Z)-diene substituted by carboxy groups at positions 3 and 26. Isolated from Schisandra henryi and Schisandra propinqua, it exhibits cytotoxic and anti HIV activities.
in vivo
Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation[2].
Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points[2].
| Animal Model: | Sprague–Dawley rats (200-300 g), ischemia–reperfusion model[2] |
| Dosage: | 1 mg/kg |
| Administration: | Intragastric; 6 hours and 2 hours before brain ischemia |
| Result: | Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points. |
References
[1] Sun HD, et al. Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase. J Nat Prod. 1996 May;59(5):525-7. DOI:10.1021/np960149h
[2] Feng T, et al. Protective effects of nigranoic acid on cerebral ischemia-reperfusion injury and its mechanism involving apoptotic signaling pathway. Cell Biochem Biophys. 2015 Jan;71(1):345-51. DOI:10.1007/s12013-014-0204-1
NIGRANOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
NIGRANOIC ACID Suppliers
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- Fax
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- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
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- Fax
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- info@apinchemicals.com
- Country
- United Kingdom
- ProdList
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