ChemicalBook > CAS DataBase List > 1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE

1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE

Product Name
1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE
CAS No.
99735-30-5
Chemical Name
1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE
Synonyms
(R)-1-Benzyl-3-(Boc-amino)pyrrolidine;tert-Butyl N-(1-benzylpyrrolidin-3-yl)carbamate;1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE;1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine >N-benzyl-3-(R)-((1,1-dimethylethoxycarbonyl)amino)pyrrolidine;N-[1-(phenylmethyl)-3-pyrrolidinyl]carbamic acid tert-butyl ester;Carbamic acid,N-[1-(phenylmethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester
CBNumber
CB8695855
Molecular Formula
C16H24N2O2
Formula Weight
276.37
MOL File
99735-30-5.mol
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1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE Property

Melting point:
113 °C
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
color 
White to Almost white
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Safety

HS Code 
9999999999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B1357
Product name
1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine
Purity
>98.0%(GC)(T)
Packaging
10g
Price
$52
Updated
2022/04/27
TRC
Product number
B750245
Product name
tert-Butyl(1-Benzylpyrrolidin-3-yl)carbamate
Packaging
500mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB147316
Product name
1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine
Packaging
2g
Price
$55
Updated
2021/12/16
Apolloscientific
Product number
OR311199
Product name
tert-butylN-(1-benzylpyrrolidin-3-yl)carbamate
Packaging
500mg
Price
$102
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB147316
Product name
1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine
Packaging
5G
Price
$110
Updated
2021/12/16
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1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE Chemical Properties,Usage,Production

Synthesis

24424-99-5

18471-40-4

99735-30-5

General procedure for the synthesis of 1-benzyl-3-(Boc-amino)pyrrolidine from di-tert-butyl dicarbonate and 1-benzylpyrrolidin-3-amine: 1-benzylpyrrolidin-3-amine (10 g, 57 mmol) was dissolved in 3M aqueous sodium hydroxide (21 ml) and tertiary butyl alcohol (114 ml) in a 500 ml reaction vessel. Di-tert-butyl dicarbonate (Boc2O; 13.07 g, 59.9 mmol) was slowly added to the above solution under stirring conditions. The reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the reaction mixture was extracted with ethyl acetate (2×). The organic layers were combined and washed sequentially with 0.1 N hydrochloric acid solution and saturated brine, then dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The crude product obtained was purified by silica gel column chromatography to afford 15.25 g of 1-benzyl-3-(Boc-amino)pyrrolidine as a white solid (97% yield). The structure of the product was confirmed by 1H-NMR (200 MHz, CDCl3) and LC/MS (M+H: 277).

References

[1] Patent: WO2008/54154, 2008, A1. Location in patent: Page/Page column 76; 80-81; 162-163; 168
[2] Patent: WO2007/52938, 2007, A1. Location in patent: Page/Page column 22-23

1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE Suppliers

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View Lastest Price from 1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE manufacturers

Career Henan Chemical Co
Product
1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE 99735-30-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-11

99735-30-5, 1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINERelated Search:

(S)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE 1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE 3-N-BOC-AMINO-1-[2-AMINO-1-(2-METHOXY-PHENYL)-ETHYL]-PYRROLIDINE (3-BOC-AMINO-PYRROLIDIN-1-YL)-P-TOLYL-ACETIC ACID (3R)-(+)-1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE (3-BOC-AMINO-PYRROLIDIN-1-YL)-NAPHTHALEN-2-YL-ACETIC ACID TRANS-1-BENZYL-4-TERT-BUTOXYCARBONYLAMINO-PYRROLIDINE-3-CARBOXYLIC ACID,TRANS-RACEMIC-1-BENZYL-4-TERT-BUTOXYCARBONYLAMINO-PYRROLIDINE-3-CARBOXYLIC ACID 3-N-BOC-AMINO-1-[2-AMINO-1-(3-AMINO-PHENYL)-ETHYL]-PYRROLIDINE 3-N-BOC-AMINO-1-[2-AMINO-1-(3-BROMO-PHENYL)-ETHYL]-PYRROLIDINE 3-N-BOC-AMINO-1-[2-AMINO-1-(4-BENZYLOXY-PHENYL)-ETHYL]-PYRROLIDINE 3-N-BOC-AMINO-1-[2-AMINO-1-(3-PHENOXY-PHENYL)-ETHYL]-PYRROLIDINE 3-N-BOC-AMINO-1-[2-AMINO-1-(3,4-DIMETHOXY-PHENYL)-ETHYL]-PYRROLIDINE 3-N-BOC-AMINO-1-[2-AMINO-1-(4-BROMO-PHENYL)-ETHYL]-PYRROLIDINE 3-N-BOC-AMINO-1-[2-AMINO-1-(2,5-DIMETHOXY-PHENYL)-ETHYL]-PYRROLIDINE 3-N-BOC-AMINO-1-[2-AMINO-1-(2-AMINO-PHENYL)-ETHYL]-PYRROLIDINE 3-N-BOC-AMINO-1-[2-AMINO-1-(2-CHLORO-PHENYL)-ETHYL]-PYRROLIDINE 3-N-BOC-AMINO-1-[2-AMINO-1-(3-FLUORO-PHENYL)-ETHYL]-PYRROLIDINE 3-N-BOC-AMINO-1-[2-AMINO-1-(4-CHLORO-PHENYL)-ETHYL]-PYRROLIDINE

  • 1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE
  • (R)-1-Benzyl-3-(Boc-amino)pyrrolidine
  • Carbamic acid,N-[1-(phenylmethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester
  • tert-Butyl N-(1-benzylpyrrolidin-3-yl)carbamate
  • N-benzyl-3-(R)-((1,1-dimethylethoxycarbonyl)amino)pyrrolidine
  • N-[1-(phenylmethyl)-3-pyrrolidinyl]carbamic acid tert-butyl ester
  • 1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine &gt
  • 99735-30-5
  • 3-Aminopyrrolidines
  • 3-Aminopyrrolidines (Racemic)
  • 3-Aminopyrrolidines
  • 3-Aminopyrrolidines (Racemic)