1-N-CBZ-3-METHYL PIPERAZINE
- Product Name
- 1-N-CBZ-3-METHYL PIPERAZINE
- CAS No.
- 84477-85-0
- Chemical Name
- 1-N-CBZ-3-METHYL PIPERAZINE
- Synonyms
- CHEMPACIFIC 38150;1-Cbz-3-methylpiperazine;4-Cbz-2-methylpiperazine;4-N-CBZ-2-METHYL PIPERAZINE;1-N-CBZ-3-METHYL PIPERAZINE;N-1-CBZ-3-METHYL-PIPERAZINE;(R)-1-CBZ-2-METHYL-PIPERAZINE;4-N-CBZ-2-Methylpiperazine-HCl;(R)-1-N-CBZ-2-METHYL-PIPERAZINE;4-BENZOXYCARBONYL-2-METHYLPIPERAZINE
- CBNumber
- CB8696175
- Molecular Formula
- C13H18N2O2
- Formula Weight
- 234.29
- MOL File
- 84477-85-0.mol
1-N-CBZ-3-METHYL PIPERAZINE Property
- Boiling point:
- 358.0±30.0 °C(Predicted)
- Density
- 1.105±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 8.50±0.40(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B288698
- Product name
- Benzyl3-Methylpiperazine-1-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- AS12956
- Product name
- (R)-2-Methylpiperazine-1-carboxylic acid benzyl ester
- Purity
- 96% ee
- Packaging
- 1g
- Price
- $88
- Updated
- 2021/12/16
- Product number
- 2978AC
- Product name
- 1-Cbz-3-Methylpiperazine
- Packaging
- 100mg
- Price
- $93
- Updated
- 2021/12/16
- Product number
- 2978AC
- Product name
- 1-Cbz-3-Methylpiperazine
- Packaging
- 1g
- Price
- $188
- Updated
- 2021/12/16
- Product number
- 84477850
- Product name
- Benzyl3-methylpiperazine-1-carboxylate
- Packaging
- 5g
- Price
- $290.88
- Updated
- 2021/12/16
1-N-CBZ-3-METHYL PIPERAZINE Chemical Properties,Usage,Production
Synthesis
109-07-9
501-53-1
84477-85-0
Example 1: 5.00 g (0.0499 mol) of racemic 2-methylpiperazine was added to a 100 mL four-necked flask and dissolved in 44 g of 1-butanol (0.05 wt% in water). The solution was cooled to 0°C and 8.47 g of benzyl chloroformate (0.0489 mol, 98.5% purity as determined by HPLC, equivalent to 0.98 equivalents) was added slowly dropwise over a temperature range of 0 to 8°C. After the dropwise addition, the reaction mixture was stirred at 0 to 5 °C for 2 hours. During this time, a sample was taken and analyzed by HPLC using the internal standard method (internal standard: anisole), and the yield of 1-Benzyloxycarbonyl-3-methylpiperazine was measured to be 83.9% (based on 2-methylpiperazine). Subsequently, the reaction mixture was continued to be stirred at room temperature for 12 hours and analyzed again and the yield was increased to 85.1%. Example 3: The reaction conditions were the same as in Example 1 , with the difference that the amount of benzyl chloroformate was increased to 10.1 g (0.0597 mol, 1.17 eq.). After 2 hours of reaction at 0 to 5 °C, HPLC analysis showed 93.8% yield of 1 -benzyloxycarbonyl-3-methylpiperazine (based on 2-methylpiperazine). The yield was further increased to 95.1% after continued stirring at room temperature for 12 hours.
References
[1] Patent: EP1548010, 2005, A1. Location in patent: Page/Page column 16; 17
[2] Patent: EP1548010, 2005, A1. Location in patent: Page/Page column 18
[3] Patent: EP1548010, 2005, A1. Location in patent: Page/Page column 19
[4] Synthetic Communications, 2007, vol. 37, # 20, p. 3623 - 3634
[5] Patent: EP3124482, 2017, A1. Location in patent: Paragraph 0476; 0477
1-N-CBZ-3-METHYL PIPERAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-N-CBZ-3-METHYL PIPERAZINE manufacturers
- Product
- 1-N-CBZ-3-METHYL PIPERAZINE 84477-85-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons
- Release date
- 2022-02-23