ChemicalBook > CAS DataBase List > H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH

H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH

Product Name: H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH
CAS No.: 568565-11-7
Chemical Name: H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH
Synonyms: QRPRLSHKGPMPA;[ALA13]-APELIN-13;[Ala13]-Apelin-13 - 1 mg;(Ala13)-Apelin-13 ，P1212;[Ala13]Apelin 13 (human, mouse, rat, bovine);(ALA13)-APELIN-13 (HUMAN, BOVINE, MOUSE, RAT);GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA;[Ala13]Apelin-13, human, bovine, mouse, rat (F13A) (2);H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH;(Ala??)-Apelin-13 (human, bovine, mouse, rat) acetate salt
CBNumber: CB8697662
Molecular Formula: C63H107N23O16S
Formula Weight: 1474.73
MOL File: 568565-11-7.mol

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H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH Property

Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: -20°C
pka: 3.70±0.10(Predicted)
form: powder
color: white to beige
Sequence: Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2083
Product name: [Ala13]-Apelin-13 trifluoroacetate salt
Purity: ≥96% (HPLC)
Packaging: 1 mg
Price: $128.25
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2083
Product name: [Ala13]-Apelin-13 trifluoroacetate salt
Purity: ≥96% (HPLC)
Packaging: 5 mg
Price: $545
Updated: 2025/07/31

Biosynth Carbosynth

Product number: FA109791
Product name: (Ala13)-Apelin-13 (human, bovine, mouse, rat) trifluoroacetate salt H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala-OH trifluoroacetate salt
Packaging: 500ug
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA110249
Product name: (Ala13)-Apelin-13 (human, bovine, mouse, rat) acetate salt H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala-OH acetate salt
Packaging: 2mg
Price: $133
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA109791
Product name: (Ala13)-Apelin-13 (human, bovine, mouse, rat) trifluoroacetate salt H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala-OH trifluoroacetate salt
Packaging: 1mg
Price: $157
Updated: 2021/12/16

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H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH Chemical Properties,Usage,Production

Uses

(Ala13)-Apelin-13 is a potent apelin receptors (APJ) antagonist. (Ala13)-Apelin-13 inhibits gastric motility through vagal cholinergic pathway[1].

Biological Activity

(Ala13)-Apelin-13 corresponds to Apelin-13 with a Phe-to-Ala substitution at the C-terminus (F13A) and functions as an antagonist against apelin-dependent APJ functions both in cultures and in animal studies in vivo.

in vivo

(Ala13)-Apelin-13 (1-300 pmol/60 nl; microinjected into the DVC) decreases gastric tone and motility in a dose-dependent manner in rats^[1].

Animal Model:	250-300 g, Sprague-Dawley rats^[1]
Dosage:	1-300 pmol/60 nl
Administration:	Microinjected into the DVC (dorsal vagal complex (DVC)
Result:	Decreased gastric tone and motility in a dose-dependent manner with D50?≈?27 pmol for both antrum and corpus.

References

[1] Bülbül M, et al. Apelin-13 inhibits gastric motility through vagal cholinergic pathway in rats. Am J Physiol Gastrointest Liver Physiol. 2018 Feb 1;314(2):G201-G210. DOI:10.1152/ajpgi.00223.2017
[2] O'Harte FPM,et al. Acylated apelin-13 amide analogues exhibit enzyme resistance and prolonged insulin releasing, glucose lowering and anorexic properties. Biochem Pharmacol. 2017 Dec 15;146:165-173. DOI:10.1016/j.bcp.2017.10.002

H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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568565-11-7, H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OHRelated Search:

GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE APELIN-15 (63-77) H-LYS-PHE-ARG-ARG-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH APELIN PRECURSOR (61-77) (HUMAN, BOVINE, MOUSE, RAT) TRIFLUOROACETATE APELIN (65-77) (N15-ARG 66) [HOMO SAPIENS]/[MUS MUSCULUS]/[BOS TAURUS] H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH

QRPRLSHKGPMPA

[ALA13]-APELIN-13

(ALA13)-APELIN-13 (HUMAN, BOVINE, MOUSE, RAT)

(Ala13)-Apelin-13 (human, bovine, mouse, rat) trifluoroacetate salt H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala-OH trifluoroacetate salt

(Ala13)-Apelin-13 (human, bovine, mouse, rat) acetate salt H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala-OH acetate salt

H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA-OH

[Ala13]Apelin-13, human, bovine, mouse, rat (F13A) (2)

[Ala13]Apelin 13 (human, mouse, rat, bovine)

GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA

Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala ((2) Due to the presence of a Gln in N-terMinal position this peptide can contain the pyroglutaMic forM)

L-Alanine, L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-

L-Glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-alanine

(Ala??)-Apelin-13 (human, bovine, mouse, rat) acetate salt

[Ala13]-Apelin-13 - 1 mg

(Ala13)-Apelin-13 ，P1212

568565-11-7

C63H107N23O16SxC2H4O2

C63H107N23O16SxC2HF3O2

C63H107N23O16S

peptide

Apelin receptor