ETHYL 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE
- Product Name
- ETHYL 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE
- CAS No.
- 15001-11-3
- Chemical Name
- ETHYL 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE
- Synonyms
- AKOS BBS-00004493;BUTTPARK 20\09-21;SALOR-INT L251453-1EA;ETHYL 5-AMINO-1-P-TOLYLPYRAZOLE-4-CARBOXYLATE;ETHYL 5-AMINO-1-P-TOLYL-1H-PYRAZOLE-4-CARBOXYLATE;ETHYL 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE;5-Amino-1-p-tolyl-1H-pyrazole-4-carboxylic acid ethyl ester;5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;1H-Pyrazole-4-carboxylic acid, 5-amino-1-(4-methylphenyl)-, ethyl ester
- CBNumber
- CB8702230
- Molecular Formula
- C13H15N3O2
- Formula Weight
- 245.28
- MOL File
- 15001-11-3.mol
ETHYL 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE Property
- Melting point:
- 114-116°C
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Yellow to brown Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- L251453
- Product name
- ETHYL 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $30.7
- Updated
- 2025/07/31
- Product number
- L251453
- Product name
- ETHYL 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE
- Purity
- Aldrich
- Packaging
- 250mg
- Price
- $29.8
- Updated
- 2024/03/01
- Product number
- B433830
- Product name
- ETHYL 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 044609
- Product name
- Ethyl 5-amino-1-(4-methylphenyl)-1H-pyrazole-4-carboxylate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $118
- Updated
- 2021/12/16
- Product number
- 5323AQ
- Product name
- Ethyl5-amino-1-(p-tolyl)-1H-pyrazole-4-carboxylate
- Packaging
- 1g
- Price
- $131.6
- Updated
- 2021/12/16
ETHYL 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
637-60-5
94-05-3
15001-11-3
GENERAL METHOD: Ethyl 2-cyano-3-ethoxyacrylate (2.00 g, 11.8 mmol) and 4-methylphenylhydrazine hydrochloride (2.06 g, 11.8 mmol) were dissolved in ethanol (75 mL) at room temperature, followed by the addition of triethylamine (1.65 mL, 11.8 mmol). The reaction mixture was stirred continuously at 80 °C for 8 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the ethanol was removed by rotary evaporator under reduced pressure. The residue was subjected to liquid-liquid partitioning with ethyl acetate and water. The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent being a solvent mixture of n-hexane and ethyl acetate (3:1, v/v) to afford the target compound, ethyl 5-amino-1-tosyl-1H-pyrazole-4-carboxylate (2.42 g, 78% yield).1H NMR (300 MHz, CDCl3): δ = 7.76 (s, 1H), 7.42 (d, J = 6.9 Hz, 2H), 7.01 (d, J = 6.9 Hz, 2H), 5.19 (br s, 2H), 4.30 (q, J = 7.1 Hz, 2H), 3.82 (s, 3H), 1.36 (t, J = 7.1 Hz, 3H) ppm; MS (ESI): m/z: 262 [M + H]+.
References
[1] Tetrahedron, 2017, vol. 73, # 40, p. 5959 - 5973
ETHYL 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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