2-AMINO-N-HYDROXY-BENZAMIDINE

2-AMINO-N-HYDROXY-BENZAMIDINE Property

Melting point:

71-75℃

Boiling point:

318.2±44.0 °C(Predicted)

Density 

1.34±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 2 mg/ml

form 

A crystalline solid

pka

6.74±0.69(Predicted)

color 

White to off-white

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

2-AMINO-N-HYDROXY-BENZAMIDINE Chemical Properties,Usage,Production

Uses

2-Amino benzamidoxime (ABAO compound 6) can react quickly with aldehydes to form stable 1, 2-dihydroquinazoline 3-oxides in aqueous solutions. The 2-Amino benzamidoxime reaction process consists of the formation of a Schiff base as a rate-determining step, followed by rapid intramolecular cyclization. The reaction rate is dependent on pH, indicating that protonated benzamidoxime is involved in the formation of Schiff bases as an internal generalized acid. Substituents on the aromatic ring can increase the alkalinity of the aromatic amine, thus speeding up the reaction. The reactive properties of 2-Amino benzamidoxime make it a potential platform for the development of new bioconjugated strategies, fluorescent probes, and post-translational diversification of genetic coding libraries[1].

References

[1] Kitov P I, et al. Rapid, hydrolytically stable modification of aldehyde-terminated proteins and phage libraries[J]. Journal of the American Chemical Society, 2014, 136(23): 8149-8152. DOI:10.1021/ja5023909