1-METHYL-4-(PIPERIDIN-4-YL)-PIPERAZINE

Product Name: 1-METHYL-4-(PIPERIDIN-4-YL)-PIPERAZINE
CAS No.: 53617-36-0
Chemical Name: 1-METHYL-4-(PIPERIDIN-4-YL)-PIPERAZINE
Synonyms: 1-METHYL-4-(4-PIPERIDINYL)PIPERAZINE;1-Methyl-4-(4-piperidyl)piperazine;TIMTEC-BB SBB010183;1-methyl-4-(piperidinyl)piperazine;1-Methyl-4-(piperidin-4-yl)-piperaz;4-(1-Methyl-4-piperazinyl)piperidine;4-(4-Methylpiperazin-1-yl)piperidine;N-Methyl-4-(4-piperidinyl)-Piperazine;1-Methyl-4-(piperidin-4-yl)-piperizine;1-Methy1-4-(piperidin-4-yl)-piperazine
CBNumber: CB8708979
Molecular Formula: C10H21N3
Formula Weight: 183.29
MOL File: 53617-36-0.mol

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1-METHYL-4-(PIPERIDIN-4-YL)-PIPERAZINE Property

Melting point:: 53-56°C
Boiling point:: 261℃
Density: 0.992
Flash point:: 114℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 10.27±0.10(Predicted)
form: solid
color: Pale yellow
Water Solubility: Soluble in water.
Sensitive: Hygroscopic
InChI: InChI=1S/C10H21N3/c1-12-6-8-13(9-7-12)10-2-4-11-5-3-10/h10-11H,2-9H2,1H3
InChIKey: MRYYJGQKVGZGSB-UHFFFAOYSA-N
SMILES: N1(C)CCN(C2CCNCC2)CC1
CAS DataBase Reference: 53617-36-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HazardClass: 8
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: M220725
Product name: 1-Methyl-4-(piperidin-4-yl)piperazine
Packaging: 2.5g
Price: $155
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-1-M6
Product name: 1-Methyl-4-piperidin-4-ylpiperazine
Packaging: 5G
Price: $141
Updated: 2021/12/16

Oakwood

Product number: 018128
Product name: 1-Methyl-4-(piperidin-4-yl)piperazine
Packaging: 5g
Price: $60
Updated: 2021/12/16

Oakwood

Product number: 018128
Product name: 1-Methyl-4-(piperidin-4-yl)piperazine
Packaging: 25g
Price: $180
Updated: 2021/12/16

AK Scientific

Product number: J90391
Product name: 1-Methyl-4-(piperidin-4-yl)piperazine
Packaging: 25g
Price: $180
Updated: 2021/12/16

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1-METHYL-4-(PIPERIDIN-4-YL)-PIPERAZINE Chemical Properties,Usage,Production

Uses

It is used both as a reagent and building block in several synthetic applications. As intermediate. As an excellent catalyst for many condensation reactions.

Synthesis

109-01-3

79099-07-3

53617-36-0

General procedure for the synthesis of 1-methyl-4-(4-piperidinyl)piperazine from N-methylpiperazine and N-tert-butoxycarbonyl-4-piperidinone: N-tert-butoxycarbonyl-4-piperidinone (1.50 g, 7.53 mmol) was dissolved in dichloromethane (25.0 mL) at 0 °C, followed by stirring of the reaction mixture for 16 h at room temperature. Upon completion of the reaction, the reaction solution was cooled to 0 °C, neutralized by addition of saturated aqueous sodium bicarbonate solution, and then extracted with dichloromethane. The organic layers were combined, dried with anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure. The concentrated residue was dissolved in 1.0 N hydrochloric acid and extracted with ethyl acetate. The aqueous layer was alkalized with 48% aqueous sodium hydroxide and extracted again with dichloromethane. The organic layer was dried over anhydrous sodium sulfate and filtered, then the filtrate was concentrated under reduced pressure. The residue was dissolved in methanol (25.0 mL), concentrated hydrochloric acid (5.0 mL) was added, and stirred at 40°C for 12 hours. After the reaction solution was concentrated and dried, the residue was dissolved in distilled water, alkalized with 48% aqueous sodium hydroxide and subsequently extracted with dichloromethane. The organic layer was dried with anhydrous sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure to give 4-(1-methylpiperazin-4-yl)piperidine (0.826 g, 4.51 mmol, 60% yield) as a white solid.

References

[1] Patent: TW2016/2093, 2016, A. Location in patent: Paragraph 0319
[2] Patent: EP3263565, 2018, A1. Location in patent: Paragraph 0374; 0375

1-METHYL-4-(PIPERIDIN-4-YL)-PIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-METHYL-4-(PIPERIDIN-4-YL)-PIPERAZINE Suppliers

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View Lastest Price from 1-METHYL-4-(PIPERIDIN-4-YL)-PIPERAZINE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 1-METHYL-4-(PIPERIDIN-4-YL)-PIPERAZINE 53617-36-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-22

Shaanxi Dideu New Materials Co. Ltd

Product: 1-METHYL-4-(PIPERIDIN-4-YL)-PIPERAZINE 53617-36-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 10000KGS
Release date: 2025-02-18

Wuhan Xinhao Biotechnology Co., Ltd

Product: 1-Methyl-4-(4-piperidinyl)piperazine 53617-36-0
Price: US $10.00-100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 MT/Month
Release date: 2024-03-20

53617-36-0, 1-METHYL-4-(PIPERIDIN-4-YL)-PIPERAZINERelated Search:

1-METHYL-4-(PIPERIDIN-4-YL)-PIPERAZINE 1-METHYL-4-(PIPERIDIN-4-YL)-PIPERAZINE

TIMTEC-BB SBB010183

4-(1-Methyl-4-piperazinyl)piperidine

Piperazine, 1-methyl-4-(4-piperidinyl)- (9CI)

1-Methyl-4-(4-piperidino)piperazine, 98%

1-Methyl-4-(piperidin-4-yl)-piperizine

1-METHYL-4-(4-PIPERIDINYL)PIPERAZINE

N-Methyl-4-(4-piperidinyl)-Piperazine

3-(2-methyl-1-piperidinyl)-2-phenyl-1-propanol

1-Methyl-4-(4-piperidyl)piperazine

4-(4-Methylpiperazin-1-yl)piperidine

Piperazine, 1-Methyl-4-(4-piperidinyl)-

1-Methyl-4-(piperidin-4-yl)piperazine.HCl

1-Methyl-4-(4-piperidinyl)piperazine 3HCl

1-methyl-4-(piperidinyl)piperazine

1-Methyl-4-(piperidin-4-yl)piperazine trihydrochloride

1-Methyl-4-(piperidine-4-yl)-piperazine

1-Methy1-4-(piperidin-4-yl)-piperazine

1-Methyl-4-(piperidin-4-yl)-piperaz

1-N-Methyl-4-(4-piperidin-4-yl)-piperazine

53617-36-0

436099-99-0

PIPERIDINE