ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE
- Product Name
- ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE
- CAS No.
- 2134-36-3
- Chemical Name
- ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE
- Synonyms
- Ethyl 4-chloro-2-Methylpy...;Ethyl 4-chloro-2-methyl-5-pyrimidinecarboxylate;ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE;methyl 4-chloro-2-methylpyrimidine-5-carboxylate;4-Chloro-2-Methyl-pyriMidine-5-carboxylic acid ethyl ester;5-Pyrimidinecarboxylic acid, 4-chloro-2-methyl-, ethyl ester;ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE ISO 9001：2015 REACH
- CBNumber
- CB8712031
- Molecular Formula
- C8H9ClN2O2
- Formula Weight
- 200.62
- MOL File
- 2134-36-3.mol
ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE Property
- Melting point:
- 31 °C
- Boiling point:
- 276℃
- Density
- 1.265
- Flash point:
- 121℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.16±0.29(Predicted)
- Appearance
- Off-white to light yellow <31°C Solid,>31°C Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E940378
- Product name
- Ethyl4-chloro-2-methylpyrimidine-5-carboxylate
- Packaging
- 1g
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 4H23-5-29
- Product name
- Ethyl 4-chloro-2-methylpyrimidine-5-carboxylate
- Packaging
- 1g
- Price
- $475
- Updated
- 2021/12/16
- Product number
- 112409
- Product name
- Ethyl 4-chloro-2-methylpyrimidine-5-carboxylate
- Packaging
- 1g
- Price
- $605
- Updated
- 2021/12/16
- Product number
- 35511
- Product name
- Ethyl4-chloro-2-methylpyrimidine-5-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $850
- Updated
- 2021/12/16
- Product number
- 4H23-5-29
- Product name
- Ethyl 4-chloro-2-methylpyrimidine-5-carboxylate
- Packaging
- 250mg
- Price
- $160
- Updated
- 2021/12/16
ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
53135-24-3
2134-36-3
General procedure for the synthesis of ethyl 4-chloro-2-methylpyrimidine-5-carboxylate from ethyl 2-methyl-4-hydroxypyrimidine-5-carboxylate: Phosphoryl chloride (50 mL, 23.33 mmol) was slowly added to ethyl 2-methyl-6-oxo-1,6-dihydropyrimidine-5-carboxylate (Intermediate 174, 4.25 g, 23.33 mmol). The resulting insoluble mixture was heated to reflux for 30 min. During the reaction, the product gradually dissolved in phosphoryl chloride while the feedstock remained insoluble. Upon completion of the reaction, the excess phosphoryl chloride was evaporated under reduced pressure. The residue was evaporated to dryness, redissolved in ethyl acetate (100 mL) and washed sequentially with water (75 mL) and saturated saline (75 mL). The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated to give the crude product. The crude product was purified by fast silica gel column chromatography with an eluent of 10% to 30% ethyl acetate/isohexane gradient. The purified grades were collected and concentrated to dryness to afford ethyl 4-chloro-2-methylpyrimidine-5-carboxylate (2.70 g, 57.7% yield) as a colorless oil.1H NMR (400.132 MHz, CDCl3) δ 1.42 (3H, t), 2.78 (3H, s), 4.44 (2H, q), 9.05 (1H, s). Mass spectrum (ESI+) m/z (M + H)+ = 201; HPLC retention time tR = 2.17 min.
References
[1] Patent: US2009/264401, 2009, A1. Location in patent: Page/Page column 117-118
[2] Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 25, p. 435
[3] Shionogi Kenkyusho Nenpo, 1952, # 2, p. 76,78
[4] Chem.Abstr., 1957, p. 10008
[5] Journal of the Chemical Society, 1937, p. 367
ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE manufacturers
- Product
- ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE 2134-36-3
- Price
- US $100.00-50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-11-13
- Product
- ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE 2134-36-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-07
- Product
- ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE 2134-36-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons
- Release date
- 2020-02-03