S-(4-NITROBENZYL)-6-THIOINOSINE

ChemicalBook > CAS DataBase List > S-(4-NITROBENZYL)-6-THIOINOSINE

S-(4-NITROBENZYL)-6-THIOINOSINE

Product Name: S-(4-NITROBENZYL)-6-THIOINOSINE
CAS No.: 38048-32-7
Chemical Name: S-(4-NITROBENZYL)-6-THIOINOSINE
Synonyms: NBMPR;NBTI;NSC 296962;nitrobenzylthioinosine;4-nitrobenzylthioinosine;6-(p-nitrobenzylthio)inosine;S6-(4-nitrylbenzyl)thioinosine;S-(4-NITROBENZYL)-6-THIOINOSINE;S-(P-NITROBENZYL)-6-THIOINOSINE;4-Nitrobenzyl-6-mercaptoinosine
CBNumber: CB8713230
Molecular Formula: C17H17N5O6S
Formula Weight: 419.41
MOL File: 38048-32-7.mol

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S-(4-NITROBENZYL)-6-THIOINOSINE Property

Melting point:: 187-190 °C(lit.)
Boiling point:: 770.2±70.0 °C(Predicted)
Density: 1.3904 (rough estimate)
refractive index: 1.6460 (estimate)
storage temp.: 2-8°C
solubility: 0.1 M HCl: slightly soluble
form: solid
pka: 13.08±0.70(Predicted)
color: white
CAS DataBase Reference: 38048-32-7(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
RTECS: UO9025000
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N2255
Product name: S-(4-Nitrobenzyl)-6-thioinosine
Purity: ≥98%, solid
Packaging: 25mg
Price: $83.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: N2255
Product name: S-(4-Nitrobenzyl)-6-thioinosine
Purity: ≥98%, solid
Packaging: 100mg
Price: $265
Updated: 2024/03/01

Cayman Chemical

Product number: 16403
Product name: S-(4-Nitrobenzyl)-6-thioinosine
Purity: ≥98%
Packaging: 25mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 16403
Product name: S-(4-Nitrobenzyl)-6-thioinosine
Purity: ≥98%
Packaging: 50mg
Price: $78
Updated: 2024/03/01

Sigma-Aldrich

Product number: N2255
Product name: S-(4-Nitrobenzyl)-6-thioinosine
Purity: ≥98%, solid
Packaging: 250mg
Price: $528
Updated: 2024/03/01

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S-(4-NITROBENZYL)-6-THIOINOSINE Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

It is a prototype inhibitor of the human equilibrative nucleoside transporter (hENT1), and is a high affinity ligand with a Kd of 0.1-1.0 nM. Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardio

Uses

S-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog and an inhibitor of the human equilibrative nucleoside transporter (hENT1) (1,2,3). Nucleoside transporter inhibitors are useful compounds to investigate anticancer, antiviral, cardioprotective, and neuroprotective agents.

Definition

ChEBI: NBMPR is a purine nucleoside.

General Description

S-(4-Nitrobenzyl)-6-thioinosine (NBTI) belongs to the family of S⁶-substituted 6-thiopurine nucleosides, which regulate nucleoside transport mechanisms in animals. It acts as a ligand of adenosine transporter. Binding sites for NBTI is located on brain capillaries. It functions as a covalent photoaffinity probe for nucleoside transport.

Biological Activity

Equilibrative nucleoside transporter 1 (ENT1) inhibitor (K i values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).

Biochem/physiol Actions

Inhibitor of equilibrative nucleoside transporters (ENTs), particularly adenosine transporters, in central nervous system and vascular smooth muscle.

storage

Store at +4°C

S-(4-NITROBENZYL)-6-THIOINOSINE Preparation Products And Raw materials

Raw materials

Preparation Products

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S-(4-NITROBENZYL)-6-THIOINOSINE Suppliers

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38048-32-7, S-(4-NITROBENZYL)-6-THIOINOSINERelated Search:

S-(2-HYDROXY-5-NITROBENZYL)-6-THIOINOSINE S-(P-NITROBENZYL)-6-THIOINOSINE, [3H]- NITROBENZYLTHIOINOSINE, [BENZYL-3H]- S-(4-NITROBENZYL)-6-THIOINOSINE 6-[(4-NITROBENZYL)THIO]-9-BETA-D-RIBOFURANOSYLPURINE-5'-MONOPHOSPHATE, DISODIUM SALT NBTGR

S-(P-NITROBENZYL)-6-THIOINOSINE

S-(4-NITROBENZYL)-6-THIOINOSINE

NBMPR

NBTI

4-nitrobenzylthioinosine

6-(((4-nitrophenyl)methyl)thio)-9-beta-d-ribofuranosyl-9h-purin

6-(((4-nitrophenyl)methyl)thio)-9-beta-d-ribofuranosyl-9h-purine

6-(p-nitrobenzylthio)inosine

6-[(4-NITROBENZYL)THIO]-9-BETA-D-RIBOFURANOSYLPURINE

nitrobenzylthioinosine

S-(4-NITROBENZYL)-6-THIOINOSINE (NBTI) P OTENT ADENOSINE UPTA

S-(P-NITROBENZYL)-6-THIOINOSINE 98+%

S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR)

6-[(4-nitrobenzyl)thio]-9-β-d-ribofuranosylpurine

6-[(4-Nitrobenzyl)-mercapto]-inosine

6-S-[(4-Nitrophenyl)methyl]-6-thioinosine

NSC 296962

S-(p-Nitrobenzyl)-6-mercapto-9--D-ribofuranosylpurine

NBMPR, NBTI, 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine

4-Nitrobenzyl-6-mercaptoinosine

6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosyl-9H-purine

6-[[(4-Nitrophenyl)methyl]thio]-9-(β-D-ribofuranosyl)-9H-purine

S-(4-Nitrobenzyl)-6-thioinosine,99%

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-((4-nitrobenzyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol

Inosine, 6-S-[(4-nitrophenyl)methyl]-6-thio-

S6-(4-nitrylbenzyl)thioinosine

Nitrobenzylthioinosine, 10 mM in DMSO

38048-32-7

C17H17N5O6S

Bases & Related Reagents

Heterocycles

Inhibitors

Nucleotides

Sulfur & Selenium Compounds