ChemicalBook > CAS DataBase List > S-(4-NITROBENZYL)-6-THIOINOSINE
S-(4-NITROBENZYL)-6-THIOINOSINE
- Product Name
- S-(4-NITROBENZYL)-6-THIOINOSINE
- CAS No.
- 38048-32-7
- Chemical Name
- S-(4-NITROBENZYL)-6-THIOINOSINE
- Synonyms
- NBMPR;NBTI;NSC 296962;nitrobenzylthioinosine;4-nitrobenzylthioinosine;6-(p-nitrobenzylthio)inosine;S6-(4-nitrylbenzyl)thioinosine;S-(4-NITROBENZYL)-6-THIOINOSINE;S-(P-NITROBENZYL)-6-THIOINOSINE;4-Nitrobenzyl-6-mercaptoinosine
- CBNumber
- CB8713230
- Molecular Formula
- C17H17N5O6S
- Formula Weight
- 419.41
- MOL File
- 38048-32-7.mol
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S-(4-NITROBENZYL)-6-THIOINOSINE Property
- Melting point:
- 187-190 °C(lit.)
- Boiling point:
- 770.2±70.0 °C(Predicted)
- Density
- 1.3904 (rough estimate)
- refractive index
- 1.6460 (estimate)
- storage temp.
- 2-8°C
- solubility
- 0.1 M HCl: slightly soluble
- form
- solid
- pka
- 13.08±0.70(Predicted)
- color
- white
- CAS DataBase Reference
- 38048-32-7(CAS DataBase Reference)
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Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- RTECS
- UO9025000
- HS Code
- 29349990
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- N2255
- Product name
- S-(4-Nitrobenzyl)-6-thioinosine
- Purity
- ≥98%, solid
- Packaging
- 25mg
- Price
- $83.7
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- N2255
- Product name
- S-(4-Nitrobenzyl)-6-thioinosine
- Purity
- ≥98%, solid
- Packaging
- 100mg
- Price
- $265
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 16403
- Product name
- S-(4-Nitrobenzyl)-6-thioinosine
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $57
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 16403
- Product name
- S-(4-Nitrobenzyl)-6-thioinosine
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $78
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- N2255
- Product name
- S-(4-Nitrobenzyl)-6-thioinosine
- Purity
- ≥98%, solid
- Packaging
- 250mg
- Price
- $528
- Updated
- 2024/03/01
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S-(4-NITROBENZYL)-6-THIOINOSINE Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
It is a prototype inhibitor of the human equilibrative nucleoside transporter (hENT1), and is a high affinity ligand with a Kd of 0.1-1.0 nM. Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardio
Uses
S-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog and an inhibitor of the human equilibrative nucleoside transporter (hENT1) (1,2,3). Nucleoside transporter inhibitors are useful compounds to investigate anticancer, antiviral, cardioprotective, and neuroprotective agents.
Definition
ChEBI: NBMPR is a purine nucleoside.
General Description
S-(4-Nitrobenzyl)-6-thioinosine (NBTI) belongs to the family of S6-substituted 6-thiopurine nucleosides, which regulate nucleoside transport mechanisms in animals. It acts as a ligand of adenosine transporter. Binding sites for NBTI is located on brain capillaries. It functions as a covalent photoaffinity probe for nucleoside transport.
Biological Activity
Equilibrative nucleoside transporter 1 (ENT1) inhibitor (K i values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).
Biochem/physiol Actions
Inhibitor of equilibrative nucleoside transporters (ENTs), particularly adenosine transporters, in central nervous system and vascular smooth muscle.
storage
Store at +4°C
S-(4-NITROBENZYL)-6-THIOINOSINE Preparation Products And Raw materials
Raw materials
Preparation Products
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38048-32-7, S-(4-NITROBENZYL)-6-THIOINOSINERelated Search:
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